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Gene information for PAICS (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10606
Official gene symbolPAICS
Full namephosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
Aliases,ADE2,ADE2H1,AIRC,DKFZp781N1372,MGC1343,MGC5024,PAIS,
Gene summaryThis gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q12
Gene position57301915 - 57327534  Map Viewer
Gene orientationplus
Gene size25620 bp
Gene sequence
OMIM ID172439