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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RGS14 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10636
Official gene symbolRGS14
Full nameregulator of G-protein signaling 14
Aliases,-,
Gene summaryThis gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq]
LocationChromosome: 5   Locus: 5q35.3
Gene position176784844 - 176799599  Map Viewer
Gene orientationplus
Gene size14756 bp
Gene sequence