Entrez gene ID | | 10893 |
Official gene symbol | | MMP24 |
Full name | | matrix metallopeptidase 24 (membrane-inserted) |
Aliases | | ,MMP25,MT-MMP5,MT5-MMP, |
Gene summary | | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq] |
Location | | Chromosome: 20 Locus: 20q11.2 |
Gene position | | 33814539 - 33864804 Map Viewer |
Gene orientation | | plus |
Gene size | | 50266 bp |
Gene sequence |
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OMIM ID | | 604871 |
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