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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CPSF4 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 10898 Official gene symbol CPSF4 Full name cleavage and polyadenylation specific factor 4, 30kDa Aliases ,CPSF30,NAR,NEB1, Gene summary Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq] Location Chromosome: 7   Locus: 7q22.1 Gene position 99036563 - 99054996  Map Viewer Gene orientation plus Gene size 18434 bp Gene sequence >CPSF4:37069406..37087839:Length=18434 CCCGGCATCCCTCGGGCGGCGGCGGCGGCGGCGGCGAGGCGAAGCGAAGGAGGAGTGTGT GCGGCGGGGCCGGCGGCGGGTAAAGGCGAGAAGGCTGCAGGAGACCGAGGGGGAGCCGGG CCGGTGGGGCCGCCGCCGCCGCCATGCAGGAAATCATCGCCAGCGTGGACCACATCAAGT TTGACTTGGAGATCGCGGTGGAGCAGCAGCTGGGGGCGCAGCCGCTGCCCTTCCCCGGCA TGGACAGTGAGCGCGGGGCCCGGGCGGGAGGGCAAGAGCGACTCGAACCCGGGACCCGCT CCTCTGTGATCCCGGGACTCCCTCGCCTCGGTCCTGAGACCTCCCCCGGCTTCCTCTGGA TCCTGGGACCCCTCCCCTTTGGTCGCAGGACTCCTCCCTCTAGGTCTTGAGAGTCCCTCC CACCTCCTCCGGGTCCTGGGATCCTCCCCTTTAGTTACCGAACTCCCTCATCTGTGGTCC CGAGACTCTTCCCACTCCATCCTGAGACCTCCTCTTCTGGATCCCGGGACGCTCCCCTTG GTTTCAGGACTCCTGACTCCCAGGCCCCCATTTCCACCGTCTGGGGACTCCTTTTACCCT CACTCGGACTCAGGAGTTCACTGCCTCGGATCTTTGGCCCTCTGCGGCTGTTCAAAGGTA ATCTGTAGGAGGGTAGACCTTGTCTGTTCGCTTAATTCTTGAATAAGGGTGGGTTATCCT GGATTGGAACTCTCCCTCAACACTCTCCCAACTGCAGGAGAGTACTAGGATATCACACCC GCTACGTTGAGCGTCTCTTCTTGATTTCATCAAAACTAGGCGGTTGGAGGAGATGTGCTG AGGGAAGGACCACCTTTCTGTAGGAGACCCCAGCTAGACTCTCAAACTCCCTTCTAGGAC TCACTCTCCTGGGAGCTCATCCCTAGTTTTTGGCCCGTCCCTACTTTTTTCTGGACCCCA ACTCTGAGTTATTCATCACACCCAGCAGCTGGTGTGGACCCTTGGCCTGAACTCCCTTCA CTGCTCCCCTTCATATGGTGGCTCCTGGCTTCCCACCTCCTACTCGGTGGGATATCTTGT ACTTTAAAAGAAACCAGTAGTTTTCTTTGTGTCTTCTTTCCTATCTGGACATACTTGAAA TCTAATGCTATAACCTTAAAGTTTGGGGGCTTGTGGAAGTCACTGAGTTCAATCCACAGA TGGGGAAACTGAGACCCAAGCGGGGGAAGGGACTTGCTGACAATCACTCAGTGCATAGCA GAGGCGGGCAAGCTCTCCAGTGTTGTGTGCTGTCGCCCACAACTACCAGCGGGGTCTCCC ACCGCTCCCAGCAGCCTCACTCCCCTCAGGCGGTCACACCTTCTCATGCACATGTGACCT CTGAGTCTGTCCCTTTATGTGTTTTTGTTGTTGTTGTTTGTTTGCTTTTGAGACAGGGGC CCCTCTGTCGCCCAGGCTGGGTGCAGTGACGCAATCATGGCTCAATGCAGCCTCGACTTC CCAGGCTCCAGCAATCCTCCCACCTCAGTCTCCCAAGTAGCTGGGACCACAGGCATGCAC CAACACGCCTGGCAAATTTTTTTGTGTGTATTTCTTGGTAGAGACACTATTTCATCATGT TTCCCAGGGTTGGTCTTGAACTCCTGGGCTCAAGTGATCCTTTTACCTCGGCCTTCGGAA GTACTGGGATTATAGGCATGAGCCACTGCACCTGGCATATATATATATATATATATTTTT TTTTTTTTTTTTTTCCTGCCTGTCCCACAACTTTACATGGTGATAGTTCTGTACAAGATA GTTTCATTGGAAATTAATTAAGTCTTCAAGAAGACAAGATAGTGCTTATAAGGAGACATC ATCAGACCACCCTATTTGACACAGGCACAAACACCATCACCACTGTACACTCCCTAAAAA GCAGCTGCTCAAATTCACACACACACACCCCCTCTTACCTACCCCTCGACTCTTGTGATC ATCCCTGCACATGTGGCCTTTTCCTGTCTTTTTTTTTTTTTTTTTTTTGAGACAGAGTTT TGCTTTTGTCACCCAGGCTGGAGTGCAATGGTGCGATCTCGGCTCACTGCAACCTCCACC TCCCAGGTTCAAGCAGTTCTGCTGCCTTGGCCTCCTGAGTAGCTGGGATTATAGGCGCCC ACCACCACGCCCAACTAATTTTTGTATTTTTAGTAGAGATGAGGTTTCACCATGTTGGCC AGGCTGGTCTTGAACTCCTGACCTTAAATGATCCACCTGCCTCGGCCTCCCAAAGTGCTG GGATTACGGGCATAAGCCACTGTGCCCAGCCGGCCTTTTCCTGTCTTGATGGCACTAGCT TGAGACCATGGAACCACCCACGCAGGGCAGCTCTTTTCCTCCCACCCTTCTGCCATCTGA CACATCCACAAGCCTGTGAGGGGAGGTACAGTGGCGAGGGGCCCACATACCTGTTCCTGA GGCCCGGGACACACCTAGCCATGGGTGTTGCTCCAGCCAGGGCTTCAGAGTCGGTAGGCA CCCTCCACACTCGCTGCTTGTCCATATCCTGTTCAGTTAAAGCCTAGTGAGGCCACAGCC CTTCCTCACCCATCCCTCCTCTTCATCCCCATCTGAGTTTTGGGAAGAACTGTCACTTTG CCCATAAGGCATACTCATCCTATCCACATGAGACTCAGTTCCCAGAACTGTGTATTTCTG AGCAGAAGCAACTCTAACCTCTAAAGAGAGAGACCAGAAGTACTTTCAGAATTTTTTTTT TCTTTTTTTTTGAGACAGAGTCTTGCTCTGTTACCCAGGCTGGAGCACAGTGACGCGATC TTGGCTCACTGCAACCTCTGCCTCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAGG TAGCTGGGATTACAGGCACGTGCCACCATGTCTGACTAATTTTTGCATTTTTAGTAGAGA TGGGGTTTCACCATATTGGCCAGGCTGGTCTTGAACTCCTGATGTCAAGTGATCCACCCG CCTCAGCCTCCCAAAGTGCTAGGATTACAGACGTGAGTCACCGCACCTGGCCACTTTCAG ACTTTTTGAGATGCAAATGGAGTGACCTCCCTGTGACAGCCATAAGTTCTATAACCTCAG CTGTGTCCTAGCAAAATCTGCTTGCTTCCAAGAAGCCAAGGAATCTTTTGTGATTTAGCA AGGGGAGGCATGTTAAGTGGGCTTCAGAGATGCTGTCATTGGTTTTTCAGCAATTCTAAA ATGGTTACTTGTAGAGGAAACTGTTTCTGATGCCAAGGTCAGTTTAGTCTGGCAGCTGGG GCTGGTGAATTCCTGGACTCATCAGAACAGCTGGTCCCTGGAGCCCACTGAATTCCAGCA CACTCCGACTGTGGGAATGAAAGGCTGTGCTTTTTTTTTCTTTTCTTTTCTTTTTTATTA ACAAGCAACATAATCGGCCGGGCGTTGTGGCTCACACCTGTAATCCCAGCACTTTGGGAG GCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAA CCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGCAAGGTGGCGGGTGCCTGTAGTCC CAGCTACTCGGGAGGCTGAGGCAGGAGAATGGTGTGAACCCCGGTGGGGCAGAGCCTGCA GTGAGCCGAGATCACACCACTGCACTCCAGCCTGGGCAACAGCGAGACTCCGTCTCAAAA AAAAAAAAAAAAAAAACAAAAAACAAGCAATATAATCAAAAACAAAAACACAACAACCTT AAAGCTGAAACAGCAATAAGTCAAACTGCCGCGGCAGTTCACAGTTTTACCTGGGGTACC TGCTCCCTCATTGCAAGGCAAGACTGCATTTAGTATATATGTGACCAAGAAGAATGAGAG AAGTGGAAAACACTGGAGAACAGAAAGTATCAAGAACCTTTCATCAGGCAATGCCAAAGC GCTCTGCTCTTTTCCTCTTCTTTGCCTCTGTATCCTCTGTGGTTCCAGTTCCAGCTGAAC TTGTGACAATCCCAAATCGCTCCTTCCTCTTTTTCAGTTTCTTATCATCTTCAGACTTTC TGGAAATTGAAGAGACATTCAAACCAAATCTTTGAGCTCTTTCCTTCGGCTTATCCAAGT TAACCATAGGTGTGTTCAGATGACAGACTTTTGTTGGAACTGAAGAAATCCCAAACCTAG CTGCCTGAGCAGCTTTCTTACTCTCCAAGCTCACAGGTACACTGAATTGTTCGGCCCTCT TCTGCATTCTCTCAGCCTGTGGTATTTCAGATGTAATTTTCACCACTTTCTTCTCTGCTG CCACATCAACAGTTTTTTTCAGGGGGTTCTTCCTATTTGACAAGGGGTTTTTTTCTTCTT CTGTTTCATCTCCTAGTACATCTTCATTTGCCTCCTCTTCAGCATGTTCTTCAAGATATG CCTGGAGTCTGTGGATAAGATCTTGCTTTATTCCCTTGGTCTCCAAACCACAAGAAGACA TTCTTGCTTTAGTTTAGCAAGCTTCAGCTTATGGAGCTCCACCATCTCAGTTACCATCTT GTTACCCCTCCGGGTGTGCTCTTTTAATAATTGTATGTGGGGTGGGGTGCGGTGGCTCAA TCCTAGCACTTTGGGAAGCCAAGGCAGGCGGATCACGAGGTCAGGAGTTCGAGACCAGCC TGTAATAATTGTATGTGGGCCAGGTGTGGTGGCTCACGTCTATAATCCCAGCACTTTGGG AGGCCAAGGTAGGTGGATCACTTGAAGCCAGTAGTTTGGGACCAGCCTGGCCAACATGGC AAAACCCTATCTCTACTAAAAATACAAAAAAATTGGGCAGGCATGATGGTACACCTATAA TTCCAGCTACTCAGGAAGCTGAGGCAGGAGAATCTCTTGAACCAAGGAGGCAGAGGTTAC GGTGAGCCAAGATCGCACCACCACACTCTAGCCTGGGCGACAGAGCGAGACTCTGTCTCA AAAAAATAGAAAAAAAAAATTGTGTACGGATGTTGCATATTAAAAGCAGTCCTCTGTTTC TGCACTTAATGTGCTTCCCCCTGGACTAGCATCTCAGAGGCACTGCCTCTTCCTTGAAGC CTGACCCTCCTCAGAGGCCCTGATTGTCTGTACGTCTGTGAGATCATTCCTTCCCTCTGC CTCATGTTAAGGTATCTGTGAATTCGCCCTCCTGGAGGAAGGTGTGAGCTAGGGGCCGTT AATTTATTCCTGTGTGTCAGGCACTTTGGCTCAACGCCTGTAATCCCAGCACTTTGGGAG GCCGAGGTGGGTGGATCACCTGAAGTCAAGAGTTCGAGACCAGCCTGGCCAACATGGTGA AACCCCGTCTCTACTAAAAATACAAAAATTAGCCAAGCGTGGTGGCAGGCACCTGTAATC CCAGCTACTTGGGAGGCTGAGGCAAGAGAATTGCTTGAACCTGGGAGGCAGAGATTGCAG TGAGCCAAGATCGCGTCATTGCACTCCAGCCCAGGCAACTAGAGCGAAACCCCATCTCAA AAAAAAAAAAATTATTTCTGTGATCTCGTACTCCAGCCTTCCTTTCCCCACCCACTCTTA ACTCCTTGAAAGGATCTTATATACAGGAGGCTCTCAAAGCACTGGGTAATGACTGTTCTC AATGTATGTGTCTCATTTTGTAGGGCGTGACTAACTTAAGCAGCTTCTTCCTTGCTTGGT TGGGCTTTGCAAATTTTTGCTACTTTATTTCCTGTACCCTGAACCCTTGGTGGGTCAGAG GTCAGAAGGGTTCCCTCCCACTGTCTTCAGACATTGTCAATAGCAAATTGCACCTCTTTG ATTCCTCTCCTTTTCTCTCCTTTCTACAGAGTCGGGCGCTGCTGTCTGTGAATTCTTTTT GAAAGCTGCCTGCGGCAAAGGTAAGAAACTCCGGGCTCCCTGATGTGCCTCCGGAGGCGC CCTCCCACCTCCTTCTCCCCGGCAGACTTGGAGGCCGCCAGGTCTCTGGCTTACATTGCT TTCTACAGACTAACGATCTCTGTAGATAAAACTGGTTTGGACAGGCTAGGACCCTGATGG GGTGTTCCACCTGAAACCTAAACGCAGGACTGAACCTGGCTCTAAGGCTGCCTTATCACT TCGCATTCCCCGTGGCCACAAGCTGACCTGTGACATGGAGAGAAGCCCCCAGCATTGAGA CACTCAGGAACTTTCTCAATGTCACAGAGTTAATAAGCGGCAGAGCCCAGTGTCTGAACC CAGGTCTTTCTCATTCCATAGTTTCCACTGGCTCATGGTTTTCTGTGGCCTCCCATCGAA ACACCCCATGATAACCCATCTTGCGGGGTCTTGTTCTCGATAACCAGCCCTCAACACAGA CTACACAAAACTACTGAGGTGCGAGAATCCCTTGAACCAGGGAGTCAGAGGTTGCAGTGA GCCGAGATCGTGCCATTGCACTCCAGCCTGGCAACAGAGCAAGACTCTATCTCAAAAAAA AAAAAAATCTTGCTTTATTTGCTCGTCTCCAAACCACGAGCAAGACATTCATTCTTACTT TAGTTCAGCAAGCTTCAGCTTATGGAGCTCCACTGTCTTGGTCGCCATCTTGTTACCCCT CTGGCTGTGCTCTTTTAATAATTGTATGTGGGCCGGGCTAATCCATCAGAAGTATCACTA GGGGTCAGGCGTGGTGGCTTACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGATG GATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACATCGTCTCTA CTAAAAATTCAAAAATTAGCTGGGCATGGTGACGCCCGTCTGTAATCCCAGCTACTGGGG AGGCTGAGGCAGGAGAATCACTTGAACCTGTTAGGCAGAGGTTGTAGTGAGCCAAGATCG CACCACTGCACTCCAGCCTAGGTAACAGAGTGAGACTCTGTCTTAACAAAACAAAACAAA AAAAAAAGAAAGAAAGAAGTATCACTAGGTACAACCTAAACTTTCCATGGTCTGGGCATT TTTCTCCCTGTAGGAAAATTTATTTAGGAGACTTAAATATTAATCAGAAGCTTGAAAAAG AGAGCAGAGAATCAGAGCAAAGGGCTGGTTTTAATGAATGGTTTTGGTGAGTTTTGCTTC TATAACGTAGTCATTTACCACTGAGGTAGGAGACTTTCTGGCAGATCAGCCAGGCCACCT TCACACTGTCCAGTCAGAACGTCATTACCTCCACTGAGTTTCTGGTCTCATTCCCATGTC TTTGCTCAGTAATTCTGCCCTTCTGACCAGCCACCTTCTGTTAGCACAGCCATCCCTAAC ACAGGGCATTCTGTCTCTCTGTTGACTAATACAGTAGCCACTAGTCACATGTGGCAGTTC AAATTTAAGTAAAATCAAATCACATTTAAAACAAAATTCTCAGACACACTAGTCATATTT CAAGTGCTCAGTAGTCACATGGGGCTAGCAGCTGCCATATTGGACAGCAGAAGTGTACAG CGGCCTCATTCTGGTCGGACCTCCATGGTGGTCTTGCCAGGCCACCCGTTAGAAGTCTCA CACATCCCCAGAGGCTGGCTCTGTCCCATCAGGTCCTGTCCCAGAAGGGACACGTCCCTC CATGTGTATACATCACATTTCCTCAATTCTGAAATTGGTCTTTCCTTTTTTTTTTTTTTT AAAAAAGAGGCAGCATCTTACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAGTCATAGC TGACTGCAAGCTTGACCTCCTGGGCCCAAGTGATCCTCCCACCTCAGCCTCCTCAGTAGC CAGGACTACAGGTGTACACCACCATACCCAGCTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTAACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGTGTCATCTTG GTTCACTGCAACTTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTA GCTGGGATTACAGGTGCACACCACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGAC AGGGTTTCATTATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATGCACCTGC CTTGGCCTCCCAAACTACTGCGATTGCAGGTGTGAGCCACTGTGCCTGGTCCCCAAGCTT GCTTGGCTGGCTTACTTACTTACTTACTTATTTATTTATGTAGTGAAGACAAGATCTCAG GCTGATCTCGAACTTCTTGGCTCAAGTGATTCTCCTGTCTTGGCCTTCCAAAGTGCTAGG ATCATAGATTTGAGCTCCTACACCCGGCCAAGTTCCTTTCTTTTTTTTTTTCTTTTTTTT TTTTTTGAGACAGAGTTTTGTTCTTGTCATCCAGGCTGGAGTGCAATGGCGTGATCTCCG GTCACTGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCAGCCTCAGCCTCCCAAGTAG CTGGGATTACAGGCACCCACCCGCAAGCCGGGCTAATTTTTTTTGTACTTTTAGTAGAGA TGGGGTTTCACCATGTCAGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCTACCCACC TCAGCCTCCCAGCACCTCCCCCCTTTTAATTCCTCCATCTTACAGTAATATCTGTGAGAT CATGAGTAACTTTTTTTTTTTTTTTTTTGAAAAGGTGTCTTGCTCTGTTGCCCAGGCTGG TGTGCAGTGGCGCGATCTCTGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCTGTTGTC CTGCCTCAGCCTCCCGAGTAGCTGGGACTATAGGCGCCAGCCACCATGCGCGGCTAATTT TTTGTATTTTTAGAAGAGACAGGATTTCACCGTGACAGCCAGGATGGTCTCCGTGCCAGC CAGGATGGTCTCGATCTCCTGACCTTGTGATCCGCCCACCTCGGCCTTCCAAAGTGCTGG GATTACCAGCGTGATCCACTGCGCCCGGCCATGAGTAACTATTAAAATGTAAAATGTCTG TCAGTGTAGTACCTCAAATCATGTTGCCTTCTGTGAGGGGGACCTCTGCCCCTTTCCAGG ACGTGATGCCTTCAGGTGGCTCCAGGAGTTAGGAAGTGAAGGTACCTCAGCTTCTTCAGG CCGTGTCCCCCAGGCTCAGGGTGGCCTCTCTGCTGACACCCTGTCCCTATCTTGCCGGCA GGGGGCATGTGTCCGTTTCGCCACATCAGTGGTGAGAAGACAGTTGTGTGCAAACACTGG CTGCGTGGCCTATGCAAGAAAGGGGACCAGTGTGAGTTCCTGCATGAGTATGACATGACC AAGATGCCCGAGTGCTACTTCTACTCCAAGTTCGGTAAGGCGCCTGGAGCCCTGGAGGCT CTGCTGAGAACCAGGGTGCAGAGGGGTCCGCTGGCTGCTCAGTGCCCACACTGTCTCTGC CTGCTTTTCCCATCTTTCTATTCTCAGAGGAGAACTCTGGCAGAACCTGCCAGCCTCAGC CAGCTTTTAGGGGACAGTGTGGCTATTTTCTGCTCATCTCTTTTTTTTTTTTTTTTTTTT TAAAGACATAGGGTCTCGCTATGTTTCACATACTGGTCTTGAACTCCTGGGCTCGAGTGA TCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCTGGCC CCGCGCATCACTTTGGAGTGCTTCAGTGTTTGGAGCTCTTTCAATCACTCGGATTTGAGG CTAACGAGGGTGACCCGGAAGCAGCGAGTTGTGCAGCTGGCTGCATTATGTCCGTGGTTG GTTTCTGTCCACGTCCACCTTCTCCCTGAAACCCACTTCTCCCTCCAGCGTGGGCATTGC CTCTCAGGCCCGAGCTGGTTCCTTCTCTCCAGGAGCCATGATCCTGGTGACATCTCAGCC ATCCTAAATAGCCCTTCAAAATAACAGCCTCAGATGTGTCTTCTGGTAGCAACAAACTTG CCTTGAGCCCTGCTTAGAGAATGCGTGGCCTCAGCTGTCCTGAGTGGCCTGCGTGGAGAA GCGGGAGCCCGGGTGGAGTCAGTGGGGCTGGCACGGAGTCTGGCAGAGATGTGCTCCCTG CTGGAAGGAGTCCCCAGGGTCCCCGCTCAGGTCTGCACTTCCAGGTTTCCCGGGAAGCAG CTCTGTGGGTCAGCGTGAGGCTGGCTCTGGTCCTGTGCAGGGAGCCCGGCAGGAGGCTGG AATCCTGCAGGGAGCCAGGGAGTGCAGGGTATGCTTCATGCTTTCAAAGCACTGCTGTTG GAGGAGACATTAATTATTTCAGCATCCCATCAGGCGTGGCCTGCTGGCTTATCAATGAGA GCTGTGGCTTGTTTTGTGGAGGTGGCATAAGCTGAGAAGAAATAGGACCCAAGCTTCCCA GCTCCCCAAGTGCTGTCCCTGTCATTGTGCAATGTAGCATGTTCCCCCCGATGCCTTGCC CATAGCAGCACTGGGGCAGCACTGGGATGGGGCAGTGGCCTCCCATCTGTCCCCAGAGGC AGCAGCTGGCTCTCCTGGGCAGGCTCTTAAGGCACCGCTATACAAGTGGCCTGAGGGTCG CTCCTTCCTTGCTGACAGCCCTGGTGCAGGACGCACTGTCTGCAGCTTCTGTCACCTGCA CCACAGACATTGGGTTGAGGGCCCCCTTTCCAGGCACTGGAGGGACAATGGTGAAGAGGT CCTTGCCCTGTGAAGCCTTCACTCTTGTGGTCCAGGGAAAGAGGTAGCTGATAGGCCATG AGACGAACAGAGAAGAAATTGCTTGTGACAAGTGCTTTGAAGGAAGGAAACCGTGACCAG AACCTTCTCTAGGCTGAGTGGTCAAGGATGAGGGGATTCCTGAGCTGGAAGCGGAAGACT AAGAAGGGGCTGGTCCTGGTACAGGGGGACCCATGTGGCTGGGGGGTGGCAGAGGCTGAG CCTGCGGAGGGGCCTGGGGAAGGAGTTTGCATTTCCTCTGGATTTTGAGCACAGTTGTAA ACATGGATTGGAGAAGGTGAGCCTGGAAGCGGGCAACTACTCAGGAAGGCGGTTCTTGGT GCTGGTGGTCCCTGGGGTCCGCTGCTTTGGAGAGGGCCAGGTCCACAAGTGCTTCCCCTA CCCTTGTCCCAGCTCTTAGATGTGAAGAGCCAATCAGAATGGAACTTCCTGGTCTCAATG GGTGCATTTCCATCACAGCTCCGCTGCACAGGAAGCTGGGGCTCAGAAACACTCTTCCCT GGCTCTCAGGGCTCGTCAGGCCAAAACTGGACACCAGAACCTCTTTTCCTTGGATGAAGC CAAGGTGGGCCTGGCCCCGGCCTTCCCAGTGGTCTCACGTCTGAGTTTCCCTGCAGGGGA GTGCAGCAACAAGGAATGTCCCTTCCTGCACATCGACCCCGAGTCCAAGATCAAGGACTG TCCTTGGTATGACCGTGGCTTCTGCAAGCACGGTAGGTGCCAGGGTGGGCTGGGCCCCGG GCAAGAAGCCAGTCCTCCCTTCTCTGCCCACGACCCTGGAGGCTGCCAGCTGGTCTACCT GTCCCAGCAAAACCTGACATTCTGCAGCTAGCGGCTTTCTCACACTCCTCATCTCCCTTG CCTCTCCCAAGAATGCTGGGTGGGTGGTGGTCCACCCGCTTTTTTGATAAGGAGGCCAGT GTTGGGAGGTGAGGTCCCTGCCCCGTCTCCCATGAATGGGGGACAGCCAGCATTTGAAAC CATGCTCCAGCTCTCTAACTGGTAGAGGGGACATCTAAGTGACCGGACACTTGGCTCTGC AGGTCCCCTCTGCAGGCACCGGCACACACGGAGAGTCATCTGTGTGAATTACCTCGTGGG ATTCTGCCCGGAGGGGCCCTCGTGTAAATTCATGCAGTGAGTAGCCAGCTGCTCCGCCCT CTACCCCAGCTCCCGGCCCAGGCCCTGCTGCCCTCCGTATCTTCCCTGGGCCAACTGGGC CTTGGTCACTGGGTGATGTCAGTACCAGGGCCAAGGGTGGGGGCAGGAGATGGGGAAGTA ATCCCTGCTTATGGCCACCAATGCTTCCTGAGCCCGCAGGTGGCTCTGCCTAGACCAGGA GCTGATCTTTCTTGGGTCATGGGCCATCTGGTAATGTAATGGAAGCTGTGGGATACAGAC AAACATGTAGCCTTGCATATCATTTAGGGAATTTGGGGACTTCCAGTTAAGAACCTGTGC CCTAAAGGAAAGAATTTCAGAGCCTCCCATGTGGAGGCTCAGGAAACCCTGAGCTTGGGG TTTCACATAGAATAAGTAGTCGTCTAACAGTGAGGGTAGGAGAGAACGCACCCATTTCAC ACAGCAGCACACTGAGGCACAGGGCTCAGTCCCTGGCCAAGGGCACATGGTAGCAGGTGG TGGCACCTGGTCAAAGGCAAGTCTGGGCTGGGTGTGGTGGCTCACGCCTGTAATCCCATA ACTTTGGGAGGCAGAGGAAGGCGGATCACGAGGTCAGGAGTTCGAGACTAGCCTGGCCAA TATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGTGTAGCGGCGCGTGC CTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAAAAGAATCACTTGAACCCAGGAGGTGGA AGTTGCAGTGAGCCAACATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCC ATCTCTAAATAAATAAAATAAATAAATAGCAAGTCTGTGAGCCTCCGAAGACGGGTTTTA ATTCTTGCTCTGTGGGGTTAGCACCCCTCTTGTGGCTCCATTTTCTTGTCCTTGGAGCCC AGTGCCCATCTGTCACTTTGGTTGTGGACCTGGGCTTCTGCCTGGGGTGGCACTGGGGCC ACAGACAAGCCTCCCTTCCTCCCGGCTGCCTCGCCCACACTGCTGAACCTACAGCAGGAT AACAGTCTCCAGGTCTGTGGGAACCCTGGTCCCTGCTTCTCACTGCAGGGAAGTGGCCGG TGCTGTCACTGGGTCTCACTCCCTGAATGAGAGTGCAGGCACCTGCAGGTGGCTCAGGGG CAGACCGTCACCAAGTGATGGGAGGAGGGGCTGACGCCAGAGTAAGACCCTGCGGGGAGG GGGGCTTCCCTGTGTACAGCTCCTGTGGCGCAGCAGGCACGCACCAGCACAGCCTTTGTC ATTTCCGAGAAGCACTGGCCATGAGTCTCCCAGCTCGGTGTAGGCAGGGTTGGGTCTGAG CCCAGGCAAGTCAGTTCTGTTCTCCCCGCCACTCCTGTGGCCTCCCAGGAGCAGAGCTGA GTGCCAGCCACCACCCCATCCATGCAGCTTGTGTCAGTCACTTTGTGCTGGGGCAGCTGA GTGTGATTTTCCTAGGGCTGGAATTTAAGAGCATGGCCTGGCTTCTCTTCTCATCCCCTG ACCCCACTCCTTCTCTTGTTCTCATCCCCTCTGGCTGCTGGTGACCAGCCCTCGATTTGA ACTGCCCATGGGAACCACCGAGCAGCCCCCACTGCCGCAGCAGACACAGCCTCCAGCAAA GGTACCGTGCCTGGCCTTCCTCGGTAGGAAGGAAGTGCCTTTTCTACAGCGAGAACCTCA GTGTCCCCCAGGGGTGTGGTCTGCCTTAGACCCCGCTGGACAACTTGGGAGAGGAGGGGA GTCTCCCAAGTTCCCGAAGAAAAGTCAGGAGCAAAGCCGTGTATATCTCCCTCGAGAGAC GGAGGGCCTCTTGCCCTAGAACCTCAGCAAGGCCAAGCGCAGCAGCAGACACAGTCCAGG CGCCGTGCAACTGGCCACCCGTTGTGAGATGGGGCTAACCTGGTTCAGCAGCGTCTGCCC CTGGGGCTGGCATGGAGGGCGGCCTGGGCACCGTGTCTGCTGCTCTTGCTCCTGGGTCAG ACCCTTTATTTTGCAAATAGGGAAACCGAGACTACCAGAGGGAGGGACCTGCCTGAGGTG ACACCACTGGGCAGGAGCAGGTGTGGCAGCAGAACTGACCACTCTGGCCAGCACCGCCCC TGCTCCTGTGGAGTGGAGGTTGGGAGGAGGCGCGAGAACAGGCCCGGCTGGCTCCAGTTT TCTAGATGAGGGGCCCCACAGCCAAGCAGCTGGTCCGTCCCCTCAAGCACAAGGAGAGGG GGAAATGCTGTAGACACATGGGGATCTGCAGCAGCCTCTCAATGCCAAGGGCACCCTGAG TTTGGTTATGGGAGTCGGGAGTTGAGCCAAGAGGAAGGGCTGGCGTCAAGGCAGGGCGGG CATCAGGCAGGGTTCCCAACAGGCCCATCAAGCCCAACCACCTCCTGAGCCCAATGCCTC ACCTCCTACCCTGCTGGGCTCTGGACTGGCTGCCAAAGCCCCACCAGCCCCGCTCAGTGC TAGAGGCTGAACAGCCAGGAGAGGATGCGGAGGATGTAGCTGCGTGGAGGCGCCAATCAC ATTGAACTCTTGATGGGGAAAGCCGGGAATTCCAGGTGTAGGTGCAGCCGTGCCAACCTG GGGGTTTTCTAGCTCGGGTTCTGCACTTACGGGCCAGAGCCAGGAGCCCACCTGGTGGGG AGGAGGCCCTGCTGTGGAATCCCTACCCCAGGAGCCCTGGCCCTCCTCCTGGTGGGGCTC CCTAGAGGAGGGTCCTCTCAGCCCGAGAACGCAGCTCAGTGTGTCAGGCTCCAACTGTTT TTCTGTGACTTGCTCGCCGTGTAGGCTGCTAAACATCTGGCTGAACCAAGCGTTCATCCT GACCTGAAGCCAGAACCTCAGAAACCAAAGTAAGGCCTGATCATGCCCTCGCCCCACTGC CCCAGAGACCTCCTCTTGTCTCTTTGATGTTTTGTTTTCTATTTTATTTTTCGTTTTTGT GTGTCTGCATGGTGTTTTTCGGGCAGTGGCTTCTGCCATCATCACCACATGTTTCTCTGC TGCCCACTGTCCTGAGGTGGGCCGTCGTGGAAGCCCTGCTTCCTGCCGTTTGCGGGACGA GTCCCGCCCTCTTTTTTCCTGTCCCCATCGGTAGTCTGCGTGCACGTGTTTTCCACAGTA AAACCGTGTTGTGTAACTCTTTCCAGCAAAGTAACAATCCGCCATTACAAAGGTCGTCCT CCTTGATCCAGTTAACGAGTCAGAACTCTTCTCCCAATCAGCAGAGAACCCCGCAGGTCA TCGGGGTCATGCAGAGTCAAAACAGCAGCGCGGGCAACCGGGGACCCCGGCCACTGGAGC AGGTCACCTGTTACAAGGTGAGTCCCTGGGCTGGGGGACAGGGTGGGGTCTTCCCTTACC GTCAGTGGCCATTCCCTCATGCCCCATGTGTTTGGTGAAATGAGAAAAATGAAAACATTC ATTTTTGCTGATTGTAAGCATAAAGTTACAGTCTAGTTACCATCCACTGTGGTGGGCTAG AGACTGTCCTATTTCCTACCACACTGCACTGAGGCACGGTAAAGGATGGTGAGAACGCCT GCCTAGTGAATGGACGGGGCCTGCAGGCAGGTGAGGGAAGCCCCCAAGAGGCCGGGAACA AAATAGAAACACTGATCCAGGGAAGGGTGAGCCCTTGGAGCCGCTGGCTGTCCTGGGGGC ATCCTTGGATCCTGCAGGGCACACCCGAGAAAACAGGACACTGGGTTACAGCACCCCTGT CCCCATCCCCTCCCCCAGTACATAAAATGGGACTCAGGAAGGGTGAGCTTCAAGAAACCT CCTCGAAAACTGTCCTGTTCACTCCTGGCTCTGTGGGAAGCGGGGAAAGGGGAGGAAAAT CTCTTGATAGTTTGACGTTATTAATGGGCCCTTATGTGAGTCTAGGCCTGTATTCATGTC CTTGGTTAAGGCTGGAAAGTTACAAACTAAGTTTTCTAATCTAAAATCGCCCCAGGATTG GTGTGTCCCTGGCACGTGGCAGGAGTAACCCCCAGTACTCTTTGAAGAGTATGTTCTCAA CCCAAGGCGCACACAATTCCTACAGCTGGAGTTCTGAAGAATGAGTCCAGATTAAAAATC ACAAAACAGGCTGGGTGTGGTGGTGCACGCCTGTAGTCCCAGCTACTGGGGAGGCTTAGA TGGGAGGATTGCTTGGGCCCAGGAGGTCAAGCCTGCAGTGAGCTATGACTGCACCACTGC ACTCCAGCCTGGGCAACAGACTGAGACTCTTTGTCTCCAAAAAAATAAAAGAGCATGGAA GTGGGGCACTGTGTAGAGCAGACTTAGCTGTTATCTTGCCACCCTCCAGGCCTGTTAAGC GGGGCCACTTCTGTGCAGCAAGCGCCCTTAAGTCCTGGAGCCTTAGAAAGGTAGGGCTGA CCGCCCCTGTCCACAGCCTGTCACCCCATTAATGTCAGAGACACTTCATGTAAGTCCTGG ATTCCCCAGAGTCAGCTGTGGGGTCCGACAGACATGCCAGATGCCGTGAGCAGGGTGTGT GGTCCCTCCCCCAGCCATCATGTTAGCCCTACAGCCCATCGGCAGCCTCTCCATACAGAG TCACACCTGCAGATCAGACAAAGTTGAAAACACAGGGACAGCTGGGTGCGGTGGCTCACG CCTGTAATCCCAGCACTTTGGGAGGCCGAGGGGAGCAGGTCACAAGGTCAGGAGTTCGAG ACCATCCTGGCCAACATAGAAGAAAGAAAACAGGAATTGCAGAGCCAGGGAATAGAGCTG GCAAGAGTGTTGGGTGCCAACTGGGCAGAGCCCCTCAGGGCAGCAGGGACTCAGGGGTGG GTGTCAGTACAGAGTCAGTGCCCCCAGCTGCCTCCTGACCCTTTTGTTCAGTGCTTGAGG CTGCCGTTTTAGGAGTCATAGAGTAAAGAGAAGCTATGGAAGGGCCTGGATAATCAGGAC TGGGATGAGGCAGGGTCAGGGCTGGATTTGTCATGTGGCTCTGCAGGCTCCCCTTACCCA AGTCTAAGCATCGTCCCATCTCTCTGATCCTGTAATCAAAACCTGTCCCCAAGGTAGCTT AGGTGTGTCACAGCCACGAGGGAAAACGTTGGGTACAGCCCACCCTCTGTCCCCAGCAGT GGCTCCCCAAGGGAGGGGAGGCTGGGACACTTCTGATGCTGTTCCCTCCCATCTCCTGCC AGGGAACCCCAGACCTTGGCTCAGAGGTAAGTGACTGGCCTGTGGTGCAGAAGGGCTTGG TCCCCAGACGGGGTGGCGGAGCTCAGGTGCCACGGGCTTCTCTTTGTCCTGCTACCCACT TGGGAGTCCCTCCCTGGGCAGGCCATGTGTCCAGGTGGGAGAGTTGTGGGCCTGAAAGAG CAGGTCGCTAGCAGGTCGCCTTCTGGCGGCCTTGTTCTCCCTTGCATCTGCGGAGTTGCT GGCTAGTTTCTGCACCACTGCACTTTCCATCCTGAGCTCCCTCACCCTCTAATTTGAAAG AAACTCTGTACCACTGAGAATTTCAGAGTCATGTCCCGACTGGGGACTTGGTGGATGATT TGGGATTTGGTGGGCACTCCCTTAGTTGAAAACTGCATTTGAACAGTGTTGTTGTCTGTC TCTCCTCTTCCCCCACTTCCTGCTGTTCCCAGTGTGGCGAGAAAGGACACTACGCCAACA GATGCACCAAAGGGCACTTGGCCTTTCTCAGTGGACAGTGACAGCAGCTGGAGCCAGCTC CGAGCAGCCCGGGGGCCCCGCTGTTGGGAGTGTGCATTTAACTGTTTCATGCGCTTGTTG GCGCGACTGTGGCTCGAGCTGGCCCGCAGACACGTGGGTTTCATCACTCTGAGGGGCCAC GTCTGTTAGTTTCCTATCATTTTGCCTTAGTATTTTTTGAAAAAGGGACATGTGTCCTGT GGGTCCCTGCAGTCGACATCATGTTTGGCTGGGCATCGATGCCTCCTTTCTGGGACTCCC GGCACAACTCCCCTCATCCAGGGAGGGAGGCAGCTGCTGGGGAGGGGCTTGGCTAGGTAG TTCTGTGTGGCGGTGGTCATTCCCCTCATTAAACACCAGTTCTTGGTGACGCCAGGGGCT GGTAGGTCATTCAAAGCTGTGGCCAGCTCACGCCTGCTTCCTCCCTCCCTGCCCTGCTGA ATCCTAAAGCTGTGCCTATATCTGTGATTTGAATGAGGGAGCCCTTTGGGGCAAATTCAG GTGCCCCCATTGCCTCAGGCTGGCCCTGGTCCCAGGTGGCAGCGGTTGAGGAGGGGTACA GGGCTCTCAAGCCTGAGGTTTTCTTCTCTGGGCTTAATTTTCTCTTGGGGTACGTGCCTG ACAGTGTTTAAGGTGTCCGTTGAACTGGAGTTGCAGACTTTTAAATAGATGACCCCTTCA GATCATCTGTGCCTACCTCCTGCCCATCAGGCGTCTACACTGTCACTCAGACACCTGTGG CATGTGGAGGAGACTGCCCTGTCCTGAGCCTGGAAAATGTGAAACTGTCTCCTGCAACCT GCTGGGCATGTGGGCCTGGCTGTGTTCAATTGCAAGAACAATTTTTATGAAATGGATTAA AGCTTGTTTTTTAA OMIM ID 603052