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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MSL3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10943
Official gene symbolMSL3
Full namemale-specific lethal 3 homolog (Drosophila)
Aliases,DKFZp586J1822,MSL3L1,
Gene summaryThis gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq]
LocationChromosome: X   Locus: Xp22.3
Gene position11776278 - 11793872  Map Viewer
Gene orientationplus
Gene size17595 bp
Gene sequence
OMIM ID300609