Entrez gene ID | | 10943 |
Official gene symbol | | MSL3 |
Full name | | male-specific lethal 3 homolog (Drosophila) |
Aliases | | ,DKFZp586J1822,MSL3L1, |
Gene summary | | This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq] |
Location | | Chromosome: X Locus: Xp22.3 |
Gene position | | 11776278 - 11793872 Map Viewer |
Gene orientation | | plus |
Gene size | | 17595 bp |
Gene sequence |
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OMIM ID | | 300609 |
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