Entrez gene ID | | 10988 |
Official gene symbol | | METAP2 |
Full name | | methionyl aminopeptidase 2 |
Aliases | | ,MAP2,MNPEP,p67,p67eIF2, |
Gene summary | | This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q22 |
Gene position | | 95867822 - 95909615 Map Viewer |
Gene orientation | | plus |
Gene size | | 41794 bp |
Gene sequence |
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OMIM ID | | 601870 |
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