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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for KDELR2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID11014
Official gene symbolKDELR2
Full nameKDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
Aliases,ELP-1,ERD2.2,FLJ45532,
Gene summaryRetention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]
LocationChromosome: 7   Locus: 7p22.1
Gene position6523849 - 6500712  Map Viewer
Gene orientationminus
Gene size23138 bp
Gene sequence
OMIM ID609024