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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CD160 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID11126
Official gene symbolCD160
Full nameCD160 molecule
Aliases,BY55,FLJ46513,NK1,NK28,
Gene summaryCD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q21.1
Gene position145715565 - 145695798  Map Viewer
Gene orientationminus
Gene size19768 bp
Gene sequence
OMIM ID604463