Entrez gene ID | | 11236 |
Official gene symbol | | RNF139 |
Full name | | ring finger protein 139 |
Aliases | | ,HRCA1,MGC31961,RCA1,TRC8, |
Gene summary | | The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq] |
Location | | Chromosome: 8 Locus: 8q24 |
Gene position | | 125487008 - 125500859 Map Viewer |
Gene orientation | | plus |
Gene size | | 13852 bp |
Gene sequence |
| |
OMIM ID | | 603046 |
|