Entrez gene ID | | 11281 |
Official gene symbol | | POU6F2 |
Full name | | POU class 6 homeobox 2 |
Aliases | | ,RPF-1,WT5,WTSL, |
Gene summary | | This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
Location | | Chromosome: 7 Locus: 7p14-p13 |
Gene position | | 39017609 - 39504390 Map Viewer |
Gene orientation | | plus |
Gene size | | 486782 bp |
Gene sequence |
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OMIM ID | | 609062 |
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