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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CHRNA2 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1135 Official gene symbol CHRNA2 Full name cholinergic receptor, nicotinic, alpha 2 (neuronal) Aliases ,-, Gene summary Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq] Location Chromosome: 8   Locus: 8p21 Gene position 27336813 - 27317278  Map Viewer Gene orientation minus Gene size 19536 bp Gene sequence >CHRNA2:complement(15175424..15194959):Length=19536 AGAGAGGCTGTGTGTGTGTGTGTGTGTGTGTATGTGTGTGTGTGTGTGAGAGAGAGAGAG AACAGCGTGAGCCTGTGTGCTTGTGTGCTGAGCCCTCATCCCCTCCTGGGGCCAGGCTTG GGTTTCACCTGCAGAATCGCTTGTGCTGGGCTGCCTGGGCTGTCCTCAGTGGCACCTGCA TGAAGCCGTTCTGGCTGCCAGAGCTGGACAGCCCCAGGAAAACCCACCTCTCTGCAGAGC TTGCCCAGCTGTCCCCGGGAAGCCAAATGCCTCTCATGTAAGTCTTCTGCTCGACGGGGT GTCTCCTAAACCCTCACTCTTCAGCCTCTGTTTGACCATGAAATGAAGTGACTGAGCTCT ATTCTGTACCTGCCACTCTATTTCTGGGGTGACTTTTGTCAGCTGCCCAGAATCTCCAAG CCAGGCTGGTTCTCTGCATCCTTTCAATGACCTGTTTTCTTCTGTAACCACAGGTAAGAA AGGTACCCAAGGCTTATGTTGAGGGCGGCATGCATGTGGAGAGCTTGTGGATATGGGGTC AAAGAAATACTAGCAGTTTCTGGGTACTCAGGAGGGGGTTATGTCTGAATGCTGGATGTC ACCTGCTCCTAGAAATATTTTAGTCTCCTGGTTGTCCCTGCTGGAGCTGTCCACAGCCAG GTGACGATGAACACCTCCTGGCTAGGATGGCTAGCCCAGTCTCAGGAATAGTGGCTTTGT TACACTGTATCTGCTCCTATGTCTTTACTACTGCTGTCCATTCTTTTGTTCATTTATTTA CTCATTCTGTAAATTGTCTATGTCCTTTAAAAGGGCTAAAAGACAGCAATGCTATTTACT GACTTAGAAGGTAAATACCTTCCAAGGTTCTTCAAGTTCTTTACAGCTGGGCTTGTTCCA AGGCTGGCATTTGTGAAGTGGATTCCTCCATCAGCTGGTGTGGTTGTTCAGATGACCTTC AAGATCCCACCCAACCTTGAGTGTTAAACTTCTGTGATTGAGCAAAACAGATATAAAAGC TAGAATTACACTCTCTAGCCCCTAAGCACCTTGAGTGCATTTATTTGGAAGAAGAAATCA TACTGGTTTCTCTAATGGAGGGGCTTCTTTGGGAGTGTAATGTTGCCAGTTGTGAAAAAG CTGAGACCTGTATGCTTGGGGAGGTTCTGGACAGCAGAAAGGAACCAGGTGGGATGGAAG CAGCCTTTTGGGAGAAGGAAATGTTAGTAAAAAGAGGAGAATGTGGACTGGTGGGTGAGA AGTTGAAAACAGAATTAGTAGAACCATGGACAGGGAAGTGAGCTCAAATCACCTTGACCT CCACGGAACCAGGATTCAGGCAGGCTAGAGATGCTGCAGTGAGTGTGGGGGTGGGGTGGG GGTGGCCTGGAACTGGTGTACGTGAGCAGCGACACAAGCCCAGTGGGGACACTGATGTCC GAGCACTTTACGTATGCAATCTCTTTTACATAGGCTTCTCTGTGTACCCCATTCACCCAG ACCCACTTTACAATTAGGGACCTCATCCCACTCTCTCCCCTTCCCCAAATCTGCCAATCC AGCCACTTAGAGGGTCAAAGTGTGCAGCTCTTTTTTTTTTGACATCTTCCTAACCAGAGG TGGAAGTTCCCTCTAATTACTGTCAATCACCTGGAACAATTCCTCCTTTGGTTTCCAGTG ACAAATTAAATGAAATGATATAGTGGGCTTATCACAGGGGATGCAGGTTTGAGGCATCTT GCTGGGAATACATCCTCTAGAGTCACTGCATCTTATTTGCACATTCTTCTGGGGGTTCCC GGGTGGCTCTCCTTGGATCTCTAAATGATGCAATGTTAGCATGCTTGGATTCCTATTCTC ACTAATGGAGAAAAAAAAATCTCCTTTTTAAAAAATGCACTTGGTTAAAAGGTGAAACAG ATGATAGCTTTGGAATTTGCAACTATGATATTGGTTGGCTGGATGAGAAAGTGAATCTGC ACTAGAGGAACCTGCTAGAATCTGGGATCCAGGTGGGCCTAGCTTTGGGGTGAGGTGCCT GTCCCCTCTCCTCACTTGTCCTCAACAGACCTCAGTCCTGATGGTGGCTTAGCAATGACA GACACAGTGCTAGGGTCTACGGAACACAGGTGAGTACTGGCTGAATTGCTAATACGAAAT CGCCCCCCTAGTTAACACCACGTTATAATTTATCGCATTCTAGTTTCGAAGCTAAAGATC TTAGCTTGAATCTCAGCTTTATCACTTTTTATCTATATGGCTTTGGTCAACTTCTCTGAA CATCAGTTTTTTTTTTTTTTTACTTACATGAAAGGGATAATTATATCTCTTCCCCACACC CTCCTAGGGGTCACGTGAGGCCCAAATAGGTGAAAGCTGCAAAAGTACCTTGTAAACCTG AAAACAACATAAATGCACAGTGTTCTTAGGAAGACGTTTTAGGAATTAACATCAAGGGGG ATTCTGAAATCCTCGTTCCCTGCCCCAAATCAGCCCTGTGTTCTAATATCTAGTAAAAAC TTCACGCCTGTATGAAAGTAGACATAAGCAATGGAATTTCACAACTCTTTTTTATTTTAA CTAGCAAATGAAACTTCTAGATGGCACTGAGCCACAGGTAAATGGGGAAGGGTGTGGGAT CTTTGAGGATCCTAAATCCTCCAGGTAGAAAGGATGAAAGAGACAAGAGACAAGGAACCA GAAAGGCAGCTTTGTGATTGTCAGGTGTTTGAATGATTGCGGAGAGCAGAGAAAAAAACT TCACCTGCTCTGCAGTTTCCCCTGGGTATTAACGAGATTTAATCTCGGATAACAACACTA GGGTCTCTAAACTCAACTCAACACAACTCAAGCATCTCTCAGATGCTTATGCAGATTCAG ACTCGAGGAAAAGCTTCCCAATGTGGAGAGTTGTAAAAAGCCTGGAAAGGATGCCTCAGG GAACTTGGGGCCTCCCTGGATGGCTTTGGAAGCAATGGGGCTAAATGAATAAAGTCATGC CCCACATTAGGGGTGGACGAGTGGATGAGACTCTAGCATTTTCCTTCCTTTTGGTTCTTC TCTACTCAAGCTCACTCAGTTCCCTGTTCCTAGTGCCTGGCACACTGTTGGCCCTGATGA AGAATGAGGTAGTACATTCTCTTACAGTCCAAGCATGAAACAACAACAACAACAAAATGA ATGAGGTAGTGGAAAGATAAACAAAGAAAAGGATAAACAATCACACTATGAATGCAAATG TTTGATGCAGTGCTGCTCCCCAAATTAAGTGAGAAGCCTTAGTCTCCTTCCTCAGGCTCT TGGAGCCCTCCTCCTGCCCTGGGTACCTTTTGCAGGTAGCTCTGAACACCTGGAACCCAC AAAGTAAGCTGGGGCTGTGCTTGGGGCTGGAGGGAAGAGGTGAATAAGATACAGTGGTCA CCCTTAAGGAGTGACCTCACGACAGGAAGTTCCACTTTTCTCTGAAAGTCCCATTTGACC TTTCAGATCAATGTAGCGATCCCATTTCCTAGGCCTCAGCCCTAAGGTGATTCCAGATGA ACACAGCTGACCTTTAAAAAGACTATTTTTGTGGTAAAATATACATAACATAATTTACCA TAATAATGTAACCATTATTAACTGTATATAGTTCATCGTGTTAAGAACATTCACATTGTT GTGTAGACATCACCACTGTCCATCTGTAGATTTTTTTCATCATCCCAAATGAAACTCCGT ACCCATTGAACAATAACTCCTCACTCCCCTCCCCCTAGCTCCTGGCACCCACCATTCTAC TTTCTGTCTCTATGAATTTGACTATTCTAGGAACATCCTATAAAAGGAATCATAATGTCT TTGTCTTTTTGTAACTGGCTTATTTTACATAGCATAATGCCCTCAAGTTTCATCCACGTT GTAGCATGGGTCAGAATTTCTGTCCTTTTTAAGGACAAATAATATTCCACTGTATGGATA GACCACATTTGTTCAACCATTCATCTGTCGCTGGATACCGGAGTTGCTTCCACTTTTTAC ACAGCTGATTGATGAACTGCACTGCATTCTGATGGAAGAGTGGAGTCAAATCTACACAGT TTGGGTGAGCTCCTGCTGCTGTGAGATGAGGGGAGGGCTTGTAAAACACATCACAGGTAT TGCTGCCTGCTTGAAAATTATTTTTATATTAAGTGACCGATACATGTTGATAGTGGGAAA TTTGGAAAATGCAGAAAACTGTCAAAAAGAATAATAATCACCTCTAATTCCTGCGCCCAG AGATAACACAGGTGATCTATTTGTATGCAGAAAAGAGATTAAAAGAGAAAAGAGCAAGAT GGTAAAGCTGTCTCTGGAAATCAGTTAGCTGTGCTGTTTCCTTTGCAATGGTCTGCTTTG GGGAAGTCCCCTGGGGACAAGTCCCTGCACCTTCGAGGGCCAGAGATCCCAGACCTTGCC ACTGCGGTTCACCTGAGCCACAGAAGCTGCTGATGCCCAGGCTGGGGTGGGTGCTGTACA AACATTCTGCATAATTTGCAGGGCGATGTGAGTTTACACATTATATAAAGCTGCACTCCT GAACGAGAGCTCTTGACAGTTATGCTGCAGGGTTTGCTGTGTGAACAGAGCAGCTCCAGT GGGGCTGTGTGTACCAGGCCTATCTGTGGAGAAGCTTCCCACTGCCAGGACTCCCTGCTT CTCCCCCTGGAGGCACCATTCTGGGAGAGCTTTGGGATGCTCTCTCGGGCAGTTCATTCC ATACATATACTGGGAACCGCCAACCTTTTGCACCTGCCAGCTGGGGATTTTCAGAGCCAG GAAGGAACCGGGAACCTCTAAGAGCTGGGACAAAGGGAGGAATCCCAGGGCAGGATGGGG TGTAGGGTGGCATGGAGGATAAGGGCAGCTCATGGACAGGGGCAATATTCTCCCAAGGGA ACAGAAGAAAAATGTAATCCTCTATTTTCAACAAGTCTTTGAATTGAAACCTTCTGGGGA AATTGATGCAGGCAGGCCCTTTTCCCCTAAAACACTCTGGTGTCTGTGCTGTAGTCAGTA TATGCCAGCAATTCCAACACATTGAAATTCACATCAAATCCTTCCCACATTCCTCTTCTC CTACTTGACCCAAACTGTCATTGTGCAATGCCACTGTGGGTCATGGGCCCTGACAACCAT AAGAGCAACCTGTTCCCTGACCAGCCCTCTGCAGTTCCCCGGGGACTTTCATGGGCACAA GTGATCCCGTTTGCTCCCGTCACTCCTCCCACAGGGCAGAAAGTGTCCAATCTTTATCTT AAGACAAAATCCCAGGGGGATTGAGTGACCTTTCACAGATCATCACCAGCCAGTGGTGGG GCCAGGACTCAAAGCGACATTTGCCAGTGCCAGCCCTGCTCTCATCTCCTGCCAGGAGGT TAGGATGGGCCGGTGCAACCGACCCTGGGAGAGATGGAGGATTAGTGATGCTGGAAACAC TGTTGAGAGTCTGTGTCAGAGTGGACGGGGGGGATGAGAATGACTAGATAGAAGTGGTTT CACAACTTCATGAATAATAATTCTGATTCTCTCATACCCGGTGGTTTACTTTTATTTTTA TTTTCTTTTTGAGATGGGATCTTGCTTGTTGTCCAGGCTGGAGTGCAGTGGCAAGATCAT AGCCCATTGCAGCCTTGACTTCCCCAGGCTCACACGACCCTCCCTTCTTGGCCTTCCCAG TAGCTGAGATCACAGGCACGCACCACTATGCCCAGCTAATTTTTGAATTTTTTGTAGAGA CGGCGGGGGGGGTCTCACTATGTTGCCCAGGCTGGTTTTGAACTGCTGAGCTCAAACACT CCTTCCATCTTGGCCTCCAAAAGAGCTGGAATTACAGGCATGAGCTACTGTACCCAGCCC TTGGTTTATATTTTTAAAGCCACTTTTACCCTTATTCTTTCTTGAAAAGTTGTGGCTAAA TACACATAACATAAAATTGATCGTTATTGGCATTTAGTACAATTCGAACAGTGTGCAGCC GTCACCACTATCTAGTTCCAGAACATTCTCACCCTTCCAAAGGAAATCCTGCACCCACTA GCTGTACCGAGAGCCTTTGTTATCTCCCTAGGCCACATACACGATGTGTCCCGGAACATG AGGCCATGCTCTTCTCTCCATAAGGGGGGCTGTTTCAAAAAATGCTAATTTGAATGTGTA AGCTTTTAAGGCAATAATGTTATTTTAGTGATATATATATATATTTTTTAAATCAAATAC TCTATAAAATAATATTTTAAAATACTGCTTTTCCCAATTTTCTCAATTATGAAACATTCA TTTCATATGAAACATTATATTTACCCCATCTTTGACATCTGTGTCCTTCTGGTCACTAGA ACCCTTTGTGTATTGATTCTCCATGTTTGGCAAATATCACTGTCACCACAGTCAAGAGGG GTAGCTGCTGCTTCTTAATCCATGAGGTGTTTGTTTATTTTTTAATAATAACTTTTTTTG AGATAAATTCAAATATCATAAAATTCCCCCATTTAAAGTGTGCAATTCGGTGAATTTTAG TATATTCACACATCTGTGTAACATCACACCGTCTAGTTCCAGAGATCTCTTATCCCCTCT AAGGGAAACTCAGTGATCATTAAGCAGTCACTTCCCATCCCTCCTTCCCGCTGCCCCTGC AACCACTAATCTACGTTCTGTTTCTATAGATTTGCCTATTCTGCATATTCCATATCAGTA GGATCATACAATGTGTAGGAAAAACCACAAACTGTTTTTCTCTGCTCTCACCCCACAACA ATCAACACGGAAGACTTCTGTGACCCCCCAAAGATGTGGGGATTTCTCCTCACCCGCAAG CAAGCTGTCAATTCTGCAGCAGAGATCAGCTGGGTGCCTTCTAATTCAATTCAGACACCA TCCATCTGGAGACAGCTCAGATCCCACACGTCGAGGGCTCAGTCCCCAACACTGCCCCCC AATGTCAATGCCGATCACAAGTCCTAGGTTGTTTTACCTGTGCTTCTAACCCACTGGCTA TAAATTGGGGTTCCCATGACCCCCTCCCTGGGTTCAACTAACTTGCTAGAGTGGCTCACA GAATTCAGGGAAACACTGGTTTACTAGCTTATAAGAGATAGTGTAAGATACAGGTGATGA GATGCATACGGCAAGGTTTGGGAAGGGGCACGGAGCTTCCATGCCCTCGCTGGGCTCATC ACCCCTCAGGAACCTCCAATGTTCTGCTATTTAGAAGCTCTTCAAAACCTGTCCTTTCGG GGTTTTATGGAGGCCTCATTATGCAGCACGATTGATTAATCCAGTGGCCATTGGCGATCA ACTTAACCTTTATCTCCTCTCCTGTCCCTGGAGGTTTGAGGGGTGGGGCTGAAAGCCCCA ACCCTTTAAAGCCTGCCTTTGTCTTCCTGTGACCAGCCCCATCCTGCAGCTGCCTAGGGG CTGCCAGCCACCAGTCATGCAAAAAGATATCATTTTGGAGATTCCCAGTATCTTAGGAGT TGTATTCCAGGAGATAGGATTGAAGACCAAATATATTTTTTACAATATCACCTTCAGTAT GTGGCTTTTTGCCACTGGCTTCTGGTACTTTGCACAATGCTTTCTAGGTTCCTCCATGCT GTAGCAAGCGTCAGCACCTCAGTCCTTTTTATGGTGGCATCATGTTCCGTTGTAAGGATT TACTGCCTTTTGTCCATCCATTCATCAGCTGATGGACATTTGTTTGGACAAAAGGCTGTT TCCACTCTTTGGATCTTGTGAATAGTACCCTGATCCTTTTATTGACCACTCTTTGCAGTA TGATTATCCCCATTTTATAGATGACCACTGAGGCAAAGCAATGGGGACCTCAGTCCCATC CTGTGCCCTCCTTTGCCCAGTAGGTCAGGGCTGGTCTTAGGGCAGAGTCGCTGGCTGACT CTGGAGAAAGAGGAAGAGGCTGATTCCTCAATAAGCCAGGGAGAGCCCAGGAGCACTTAA CTGCTGAGAGGCCTGCTGAGGGCCTTTTGCTCTCATTTCATGCCTGTGTGGAGCATGAGA AACAGAAATATGCCTATGTCAAGGATGCATGACCCTAAGAGCCCTTTCTTGGGCTTGCTC AGGTTCGGTGGTGAGAGGAAGCCTCGCAGAATCCAGCAGAATCCTCACAGAATCCAGCAG CAGCTCTGCTGGGGACATGGTCCATGGTGCAACCCACAGCAAAGCCCTGACCTGACCTCC TGATGCTCAGGAGAAGCCATGGGCCCCTCCTGTCCTGTGTTCCTGTCCTTCACAAAGCTC AGCCTGTGGTGGCTCCTTCTGACCCCAGCAGGTGAGTGTTTGTCACCTGTCATTGTAAGA CTTCATCTCATGCCTGTGGGCTCACAAATTGTAGGAAGGAGTCTGCAGGTGGATGTGTTG CAACCGTCAAAGCTGCAGGGGACTTCAGAGGCCATCAGCCAGGTGGCTGTTTCCACTGGC AGAGGTGGAGGGGCAGTCACAGCTCTGACGTTAGCATCTGTGTCACCTTAAATGTCCCCA AGCTTCAATGTCCTCAGCTGCAAAACGCAAATAGTGTTGTGTACCTCCCAGGCCTATTGT GAGGATTAAACGCAAGTTTGTGACCAGAATCTGGGATACAGGAGGCACTCGGGACACAGC GCTTTCTGTCCCAGATGGTGCTGACACGTTTTTCTGGGATTTGGAGCTGTAGTTCTCGAC TCGCTCGGACAGCAGAGCCCTGAAGGGGTGAAGCTGTTTGCTGAACACAGTGAAAACTGA CATGAGCGATGCCATAGAAACATTTTGAAAAGTTTTGTTTATCTGATAGGAAGTGGCAAA TGCCCATGGTTTAAGAAAAAATTGGGGAGGTTCCCAAAGCGGTCCATTTCCCTGTTAGCA TTAATGGTTCATCGGACAAGTGGGTGGGAACGGGAGACTGCTTACCCTGGCCAGGCTTAC TGCAATGCCAGAGCCCTTCTCCCTGCAGCCCCGCCACGTAGACCAGGCGTCTCTTCCACT TCCCTGTCCACCTGGCACTCCTCCATATGGGGCTGAATCTTGTCTCTAGATTCGTTTCCC CTCTTCCCTGCCTCTGCCCCTGCCCCTCGCCACCTGCAGCACTAGTTCTCACTCTTTTCT TCTCTAACATCACAAAACAGCTGACCTTTCCTGAGCTCCGACCCCGCAGCCTGCTCATGC TGTGCTCAGCTCTGATAGACATTATCATCTGCCATCTTCAACAATGTTTTGAGATAGGTT CTGGATAAGCATCTCCATTTTACAGATGAGCAAACTGAGGCTCAGTGAGGCTGAGTGGCT CTGATTTGATGGCAGGTGGAGAGGAAGCTAAGCGCCCACCTCCCAGGGCTCCTGGAGACC CACTCTCCTCTCCCAGTCCCACGGCATTGCCGCAGGGAGGCTCGCATACCGAGACTGAGG ACCGGCTCTTCAAACACCTCTTCCGGGGCTACAACCGCTGGGCGCGCCCGGTGCCCAACA CTTCAGACGTGGTGATTGTGCGCTTTGGACTGTCCATCGCTCAGCTCATCGATGTGGTGC GCCTGTCTTCCCACCGCTGGCCCGAGGAAGGAGATCCCAGACCACCCACCGCTTTCCCCC TGCTCCTTCCTCTACCCCAGCCCTGCCCTCACGCACAGCAGTGACTTGGGGTGGGGTTGG GGATGGCTCTTCCCAGGGCGGCTACGCTCTCCCCTCTCCCAGCTCTGGAGCTCCCTCCTA GGAGGGCATTGATTGGCAGCAGTGCCTGTGTGACCCTGGAGAATCTGAGTAAGGGTGGCA GGTTTCAGAGTGGGTGGCGGGCGGGCTGGGCTTGGGGTGTCCTATCAGAGGGTCTGAAAA CAGCCCATCCCACTCCACCCTGTCTTCTGGGGCTGGGCCCACCCCTTTAATTGCTCCTCT GTCTCTCTCTGGGCCAGGATGAGAAGAACCAAATGATGACCACCAACGTCTGGCTAAAAC AGGTGAGGGCCCCCCTCCTCCAGTCCAGGTGGCGGGTACCGGGAATCCATGGACCCCAGA CCCCTCCAGGACTTCTTCGCTAGTGAAAGACCAAGGAACAGCAAGACCCTGAACTTAGTT TACCAAGCAGATGCCATGTGGGATGTTCCCAAAGCTGACTTTTTCCACAGGGCCTGTGCT CTTTGTGGCTAGACTGGAGTCTAGTGCCTGAGAACATAGCCTCAGGCACTAGAAAGCCAA GTGGTGCTTTCCTGGGAACAGGCATCTGTTCATCCCTGCTACTTCGGAATCCTCCCCAAA GCCCCACGGGGGGTTCATTCTGCCCATTTTACAGCTCAGGAGATCACGAAGCAGAGAGAA GCTGGGCTGGAAAAGGGGGCCCAGCTGTGCCTGACTCCGAGTCCCAGGCTCCTTCTATGG GAGAACGCTGAGTGCTTAATACCTATACTGCCACCCAAATAACCCCAAACTTAGAGGCTC ACAGCAGCTCCCAGCTCACTGTATCTCATGGCTTTATGGCCAGGAGTTTGGGTGGTTTCT TCTGCTTCACATGGTGACCACTAGGGTTACTTTGTGATATTTGAGTGAGGGTTCATCTGG TCTGGAGGGTCTGAGACAGCTTAATTCACACATCTGTCCCTTAGCAGGGATGTCTGGAAG GCTCTGGAAGGTGCTGGAAGGTTCTGGAAGGCTGGACTCAGATGGGCCCTTCGCCCCCTT CAGGCATCCTCAGAGTCTCTCCAGCAGGGGAGTCAGACATCCTGCCTGGTGGTTCAGGGA TTCCAGAGTGAGAGTCCCAAGAGACAGGGAGTAAAAGAAACTGGGCCAGCATTGATCTTG TTGTATACTACTGGTCCAGACAGTCATAGAGCCCAGTTAGACTCAGGAAAGGGCGCACAG ATCCCGCTTAGGTCGGAGGCTTCCCTCCCTCTGATGCTGTAACCCAGGAGCTATCAGGGG GTCACTCATCTCATCTTTACAGATGTGACAGCTGAGGGCCAGAGGGAAGCAGGAACTTGG AAGCTACCCAGTCATGCGGTGTATGTGTGCAGGGAGGCAGGCCTAGAACCTGGGCTGCCA CAGTTGTCCCCATGGGCTGGTCACCTGGGCTTCAGGGTTGGGGTGGCAGGGCAAGGAAGG AGTACTGGAGTTTGAGGCCAGTCAGCAATGCCTCTGATTAGCTTGTGATACTGGATGAGC TACGTAACCTCTCAGAGCCTCAGTTTCCTCATTTGCAAAATGAGGATAACACAACCTACT GCCACATGCCTGGGAGGATTAATGTACCACAATTTGGTGTGGGTGCCTCAAAATGTTGGT TGGACCTGAAAACTTGACAGATGGACTACGGAGATAATACGAACCTGATGGAGGCAGGGG GACTGATTTGGACCTGCGTCGGTGGAGGCAGGGGTGGGGGCCAGACATCCCGTCTCTGGT GGGACTCCTGTGGGGCACTTGAGAGTGCAGTTTGAAGGTCCCCGGGTAACACCCCTGCCT CACTGTATGCCTCTGGCTGGTTGATTTTCCTGTCTCTGGGTCCTCAGTTTGCTCATCTGC TAAATGGGGAGATACTTTCACCTGCTCTGCATTCCCCGCTTGGCTCTCCCGTGGAGGCTT TTCCTAGATGGAGAGCATAAAACAAACCATAAACTGTGATGCCCTAAAAATGAGAGATTT CACTAGAGATGAGTGAGGTGGCCCACCAAGGTCGTCCAGCCAGGGATTGGCAGAGCGAGG ACTAGAGGCAGGACAAGGGTGAACTTCATGTGCCCGGGACCTTGACTACTAAAGTCCAGG CAAAGCGAGAAGGTTGGTTACTTGCTCAGAGCCCGTTCCCAGCACCGCAGCTCCCTCCAC TATTCTGGGCTGGGTGGGGAGCCCTGGCTGCTCCAAGGGGGCTGCTTGGCCCAATTCTGG GCATCCCCGGGGTGTGCTAGCTTTGCCCTAGGCTGCTCCCTGGAAGCGAGGTTGACACAA CTCCTTCCCCACACACAGGAGTGGAGCGACTACAAACTGCGCTGGAACCCCACTGATTTT GGCAACATCACATCTCTCAGGGTCCCTTCTGAGATGATCTGGATCCCCGACATTGTTCTC TACAACAAGTAGGAAGCCATTGGGGTCCTGGGGGGATGAGGGGAGGCCAACTTGCAGGGG CCGGGTCCATGGCCTTGGGAGGGGCCCCCCTGGTGTCAGCTTCCTCGCCTCCTTCTCGAC TGCTGTGCTGAGCATGCCTCCCCTACCTCTCTCTCTATTCCTTCATTTCTTTCCTTTTGT TCTCACTCTACACCAAAATGAATGGCAGCTGAGCACCTTTTAGGTATCAGTGCCTGGCAC TGTGCTAGAGGGACAGAGATTTGTCCATACTGAGTATTCTTTGAAAAATTTGGTGCAGGC TCAAAAAACAATACCTTGGGGTTGAAGTTGTGAGGGGTGGCAGTGTTGTTCAGACAGGCA GGCAGCATCGGGCCAGCACCTTCAAAGGGCATGTGCTCACTTGGTATGCAGTTTCCTTTT TCCCAATCATGTTGTTTTGTAGTTGTCTTCAAGACTAAAAAGGAGTAATCTTTGACCACA ATGACAAGAAGTTAATAGAAGGCAGAGGAGTCTAAAGAGAGCCCCAGGGGACAAAAATAA ATCAATAAAAAATATTTTGATGGAATAAATAGACATCTATAATTTCATTTCTGTGTTTGG TATCAGACAATTCTTCCCTTAGAAGTAAAGAAGTTAAAATGAAAAGATATTTGGTGTTAT GTTCATCTAAAAAGGTTTTCTAAGGTGGGGCTGTAAGGAGCATGGCTTCTTTGAGTTATA AATAGGTATGAAAAAGGGTTCTGTGGTCAAGTAATTTTGGATAACATTGTATGTCACAAC ACCCACCCCCATCCCCACCCAAGTCCTTTGGAAAATGGCAGAGCACAATAGCATTTTAAA AAATGTTATTTGAAGTTCTGCAGCAAAGACACCCACCTAGCCCAGCATTTCCCAATTCAT TTGATCCTACTTTGGAAATGCTATCTTTAAAGAAAGAAATAAAAGGAAAAACAACCCATT TCTGGATTTTGTGTCTTCAGATGGGTCAGATTTTTTTTTTTACACCGTCCAGTTCTGGTC AGAACTACGCCCTTGCACCTAAGCCATTTTGGGGAACACGTGTTCATCCTGGGTTCTTAC ACTGGCCGCTCTCACACAGCAGGTGCCTAGTGTTTGCAGCTGCTGCAGGACTCATGAACT CCCCACCCTGTCGTATCTCTGTGCCCCATAGCTGGCACCCAGGGTCCTTCTAGTTTCCAC TTCCTGTACATGTGGCAGAGGTCAGGAGCAAAGTCCTACATCAAATATGACTTCGAGTTT GACAATTATCCAATAAGACTTCAGCCGGTGTTACCTGATTTATTACAAGAAATGTTGGTG GGGGACAAAATTCCAAGCCGAAGTCTTGCTTACATTTAGAGATGGATCCCCTCCACCCAG ATACCCCACTCAAGGTTAAGAGGAAGGCATCTTAGAGTTTGCAAGGTTCCTTCCCCCAAG TGAGCACATGTTGCCATCTAGTGGTCATTGTTTGTGATAAACAAAATGCTTAAAAATTTT TTGTTTTTGCCTGGGCGCGGTGGCTCACACCTGTAATCCCAGTACTCTGGGAGGCCGAGG CCGGCGGATCAGGAGGTCAAGAGATTGAGACCATCCTGGCCAACATGGTGAAACCCTGTC TCTACTAAAAATACAAAAATTAGCCGGGTGTGGTGGTGGCACCTGTAGTCCCAGCTACTT GGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGTAGTGAGCCGAGA TCACACCCCTGCACTCCAGCCCGATAACAGAGTGAGATTCCGCCTCAAAAAAAAATTTTT TTTAACTTTTGTCTCAATGTATTTGTTACTCCCTTTCAAAGTTCCTATTTCCAGCCTGCC CATATCTCTACCATGGAACTACTCCATGGGGGAAAAAAGCCCCCTGTTCCCAAGTACTCT TCTGATTTCTTGGATTTTAGGATTGACTGTGGGAATTAGAAGGGGAGGGAGGATGGTTAA AGACTAGAGCAGGAGCCCACCGAGCCACCTCCTGGTGGAATCAGGGGCTGAGGCTTCCAG GAAGTGCTACCTGACTGGTCACCACTATTCCAGTGTCCCCAGACTCCTTGTGGGTCCTTG AATGCCTAGTCCCACGATACCCCTGATTCACACTCTCTGTCCCTGTGTGACCCTCTACTG GAAGGCTCTCTGCCCATTTCTCAGCCAAATCCTACCATCAGTCAAGGCCTTTTGCAAACG GCAGGCTTATCGATGACCCTGCTCACCTCCCAGAAGGGAGTTTTCCCCCAAAGGGTCTGG GGAGCACCCAGACTGCCCTCTTAGTGTTGCCAACTGCCTGCCTGATGTTGCAGTGGTTCC TGGAGACGTCTCATCTCCTCATGGCTCCTTAAAGGCAGGGACTTTTCTCATATTCCTCTT CTGCACAGCTCTGGTACAGGCCCTAGCGGATGAGGGGCTCAAAAACGCATGTTAAATGGA TACATTCAAGGTAGTATCTTCACCCGCAAAGGTGTTAGGTCTCTTCTGAGCAAGGATGAT CCCAGGTGGAAAGGGATCGCCCTCCTAAGGGACCGACTCATCATCTGCTAGGGAAGAAAA ACAGACTCATAGATATCACTCTAATATATTAAATGATCAGCTCGCAGGAGGACAGCTTTG ACCCCCTGTGATGTCATCCCCACCCAGCCAATCAGCAGCAAGCACCTGGCCACACCCACC CCTTCCCCAAAACTGCCTTTGAAAAACCCCTAACACGCACGAACTTTGGAAGAGATGCTT TGAATGCTATCTCCTTCTCCCCCGTGGCGTGGCTGGCCTTGTGTCTATTCAACTCTTTCC TTACTGCAAATAAAATAAAATATTAAATGAATAAAAATAGGCAATCAAGCAACATATACC CCATGATCACAAATATATGATTGTCATATACTGATAGATTATGTATATATAATCGTTTTA CATTTTATATATATACATATATATCATCAAAATGTTATTAGTGGTTGTTTTTAGAATTCT TGGTACTTCCTTCTATTCCTCACAATTCCTCCTTTTGTATTTAAAAAGGTAGTAATTGAC AAGACAGCTCAGTGGCTATAAATGTGCATGCCGGGGGAGACTTACACACTTGCATAAATA AACCCCGCCAGTGTGGCCGGGTCTGACTTGGTTCTTCGGGTTCCCCTGCTGCCAGCTCTC TGAGTAGCCTGGCTCAGGCAGGTGGGTGTGCAGGGGTCTCCCCAGCTCCTCTCCTCTTCT CAGTGCAGATGGGGAGTTTGCAGTGACCCACATGACCAAGGCCCACCTCTTCTCCACGGG CACTGTGCACTGGGTGCCCCCGGCCATCTACAAGAGCTCCTGCAGCATCGACGTCACCTT CTTCCCCTTCGACCAGCAGAACTGCAAGATGAAGTTTGGCTCCTGGACTTATGACAAGGC CAAGATCGACCTGGAGCAGATGGAGCAGACTGTGGACCTGAAGGACTACTGGGAGAGCGG CGAGTGGGCCATCGTCAATGCCACGGGCACCTACAACAGCAAGAAGTACGACTGCTGCGC CGAGATCTACCCCGACGTCACCTACGCCTTCGTCATCCGGCGGCTGCCGCTCTTCTACAC CATCAACCTCATCATCCCCTGCCTGCTCATCTCCTGCCTCACTGTGCTGGTCTTCTACCT GCCCTCCGACTGCGGCGAGAAGATCACGCTGTGCATTTCGGTGCTGCTGTCACTCACCGT CTTCCTGCTGCTCATCACTGAGATCATCCCGTCCACCTCGCTGGTCATCCCGCTCATCGG CGAGTACCTGCTGTTCACCATGATCTTCGTCACCCTGTCCATCGTCATCACCGTCTTCGT GCTCAATGTGCACCACCGCTCCCCCAGCACCCACACCATGCCCCACTGGGTGCGGGGGGC CCTTCTGGGCTGTGTGCCCCGGTGGCTTCTGATGAACCGGCCCCCACCACCCGTGGAGCT CTGCCACCCCCTACGCCTGAAGCTCAGCCCCTCTTATCACTGGCTGGAGAGCAACGTGGA TGCCGAGGAGAGGGAGGTGGTGGTGGAGGAGGAGGACAGATGGGCATGTGCAGGTCATGT GGCCCCCTCTGTGGGCACCCTCTGCAGCCACGGCCACCTGCACTCTGGGGCCTCAGGTCC CAAGGCTGAGGCTCTGCTGCAGGAGGGTGAGCTGCTGCTATCACCCCACATGCAGAAGGC ACTGGAAGGTGTGCACTACATTGCCGACCACCTGCGGTCTGAGGATGCTGACTCTTCGGT GCGTTGGGGTTGGGAGAGGCGCCAGCCTGGGTGGCCCCACCAACTTAGCGGGGAACCACC TTACCGCAGAGTGTGAGCTTGGGCAGCCCAGGCCCCTCTCGTGAAGGCCCACTTTCCTCA GTCATGGTCCTTAGATGGAATAAATAGCAAGAGAGCACATGTAGCTGGCCGCTTTGAGGA CGTTTATTGGCACGTGGCATGTTACACACCACGGAGTCAGGCATGAGCAGCTCAGCCTAA CAGGGATCCTGAGAGCCGGAGAGGGAGGATCCCAGATGCTGAACCCCGTGCCTCCCTCAC GCCGCCAGCTCCCACCATTGCCTTGGAGGTGGCGGCAGGCAGGGGGAGCATTTCAGGAGA GACCCAGAAAGTCAGCTGCTGCAGTGTCAGCCTTTGTCTTTTGTCTTGGATGGTCTCTTC CTCCGCCTCCTTGTTCATGGGCTCCTGAGGATCTTGCAAACTTCACTCTTCAACCATAAA CCCTGCAGATTCTTGGTTGTGCCAGGTGGACTCCGCTCCCCCGCCCCTGCCATGGCATTG GCCCCACCCTGACCCCTGCCCCAGCTCCTGTCTGCCATTGAGCAGGCCGCTACTCTAGCA CAAAATTCTACTAAGCCTAGGGAAGGATGAAAGGCCGGGAGGTTATTACTGAGTGGCCTT GATGAACAGACAAGAAAATTAATCATGATGTCATCCAGGAGCAGTGGAGAATCCAGGCTC CCTTGTCTGGGCTGTGAGCCCAAGTTCTACAAAGCCCCCGCCCCACCCCCAGCCTGCCTG GGGTCCCAACCACCTTCGCCTGTTTCCCTCTCCCCAGCTCCAGCAGGTGGGTGAGGAGGC AACCTGTGAGCAGCAAAGTCTGGTGTTGCATTGAAGTCACTGCAGGCCCCCTAGAAGGGC CCATGCCCCTGGGTGGTCGTGCCGCCTCCTTGCGTCCCTCTAGCCTCCTTTACCTATAGT CTAGGAGCATAATATGGACAGGTCTGGGCATGTGGAGGGGCTGGGATGGGAGGGGAATCA TCAGTGGAGCTTACTGGAGCCTTGAAACAGCCCGTCCCTCCCTTCCACTCACCCCGCTCC CTGTGCTGACCTTTGCTCCCCAAGGTCTCTGTGGGGCAGTTGCTGCTGCCCCCAGTGGCC GCCTGTGCAGGGGCTGTGAATGGGGGGAACACATCCCTTTCCCAGGCCTGGCCCCTGTCA CTGTGTGCTGTCTTCCCCACAGGTGAAGGAGGACTGGAAGTATGTTGCCATGGTCATCGA CAGGATCTTCCTCTGGCTGTTTATCATCGTCTGCTTCCTGGGGACCATCGGCCTCTTTCT GCCTCCGTTCCTAGCTGGAATGATCTGACTGCACCTCCCTCGAGCTGGCTCCCAGGGCAC CCCCGCTGACCATCTTTTGACCGTCTCTGCTACAGCTGCCTCTGGTGTCCCCTTTGGGAT GAGCAGGTGCCTCTCCGCGGAGTCTGGACACTGACCCAGGGATTGCAGGCTTCCATCCAG CTTAACGTTATTGTACCAGGGCTGACAGCCTGCTGGGTGCAAAGCCCTGTTTTGGATACG GAGGAGCTGGGGAAGCTCTGCAGAAGGTCGCAATAGTGTGGTGACCAAGTGGGGCAGAGT AAGATTCTCCTGGAGGAGCAGTGCAGACCCTAAGTGACAGAAGGGTCAACCAGGGGGACA GTGGGGCCAGGGTGACGAGGAAGGGAATGCAGACCTCAAAGGAGGGGCCGTGGGGGCAAA GGGGAGGGTTCTTGGATGTGGAAGGGCTTTGAACAATGTTTAGATTTGGAGATGAGCCCA AAGTGCCAGGGAGAACAGCCAGGTGAGGTGGGAGGTTGGAGAGCCAGGTGAGGTCTCTGT AAGTCAGGCTGGGGTTGAAGTTTGGAGTCTGTCCGAGTTTGCAGGGTGCTGAGCTGTATG GTCCAGCAGGGGAGTAATAAGGGCTCTTCTGGAAGGGGAGGAAGCGGGAGGCAGGGCCTG CACCTGATGTGGAGGTACAGGGCAGATCTTCCCTACCGGGGAGGGATGGATGGTTGGATA CAGGTGGCTGGGCTATTCCATCCATCTGGAAGCACATTTGAGCCTCCAGGCTTCTCCTTG ACGTCATTCCTCTCCTTCCTTGCTGCAAAATGGCTCTGCACCAGCCGGCCCCCAGGAGGT CTGGCAGAGCTGAGAGCCATGGCCTGCAGGGGCTCCATATGTCCCTACGCGTGCAGCAGG CAAACAAGAAAGACCATCCTGAGCTGCTCCTGACCCACCTCAAACTCATCTCATTTGGCC TGTCCTCCCTCCCTTCACCCCTCCTTCCCTCCCCAGGAACCCTGTTCCCTGTGCCTGGCT CCATCAGGAGGAGGCCTCACTTGGGAGTTGAAGATCTTTGCCTTTAGTTCCTTTGATTCT GAACTTCTCAAAGGCAGGTACTCTGCCTGTTATTTTTCCCACCCCCAGCACCTAGCACAG CGCCGGGTGAGTGGGGTCAGCACTTAGGGCGTTTGTTCTGAGTGGTTGAGGGGAGCAAGC TGGATTGTTTGGGCCCCAGGACTGTTGTGTAGATGGCAAAGCTGTGGTCCCGTCCCTTAT CAGCCTGCCTCGTCTCTCCCAGAGCCCCGAGGTGTGTTGACCTGCTCTGAACCCTTCAGA GCAGCCTGTGTGTGCACCTTGGAATGCAATGCACCACCCCACAGTCTGAGGCTGCACCCA GGATCCCAGGCCGAGCTGCTGCTCCTGGGATCGGGCAACAGACCTCCCCCCAACTCTGTC CAGACTGGAGGGTGGGACATTGGCAGCTAACAGATGTGGGCATCGGGTTCTCGGGACAGC ATGGAGGCTCCAGGCAGGAAGCCGAGCAGGGCGAGCTTCCAGTTTCCTTTTGGTCCTAGG GGTCCCCTCCTTCCAAACCCCAAAATGTCTCTCCCTGACACTCTCAGGGGAAACCAGCCT GGCTGTGACGCCCTGGCCCAGGCCCTGCCATGCCTCACTTCTCTCCCACAACCCCCCTGC TCATGGCACATCTGGTCTCTGGCTCCTGTCTACTCGTGTGCATGCAGCCCCCAGCGCCCC CTCTCCTCCCACTTGCTCTCCGGAGGCCTCAGAGCTCTCGGGTCCAGGCTCCCAGACCCA CTCTCCTGAGACAGTGATGTTCACTTCTGTTATCCATGTCTCCCATCCATCTTGCATGTG AATAAAGAGATTAAATAAAGCTGCACCTACTGCTGA