Entrez gene ID | | 114908 |
Official gene symbol | | TMEM123 |
Full name | | transmembrane protein 123 |
Aliases | | ,KCT3,PORIMIN,PORMIN, |
Gene summary | | This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q22.1 |
Gene position | | 102323775 - 102267056 Map Viewer |
Gene orientation | | minus |
Gene size | | 56720 bp |
Gene sequence |
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OMIM ID | | 606356 |
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