Entrez gene ID | | 1154 |
Official gene symbol | | CISH |
Full name | | cytokine inducible SH2-containing protein |
Aliases | | ,CIS,CIS-1,G18,SOCS, |
Gene summary | | The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3p21.3 |
Gene position | | 50649262 - 50643885 Map Viewer |
Gene orientation | | minus |
Gene size | | 5378 bp |
Gene sequence |
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OMIM ID | | 602441 |
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