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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for EXOSC6 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 118460 Official gene symbol EXOSC6 Full name exosome component 6 Aliases ,EAP4,MTR3,Mtr3p,hMtr3p,p11, Gene summary This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq] Location Chromosome: 16   Locus: 16q22.1 Gene position 70285833 - 70284134  Map Viewer Gene orientation minus Gene size 1700 bp Gene sequence >EXOSC6:complement(23898333..23900032):Length=1700 GCGGAAGGGGTTCGCACGCCAAGAACCGCCATGCCTGGGGATCACCGCCGCATCCGCGGC CCTGAAGAATCGCAGCCGCCGCAGCTGTACGCGGCCGACGAGGAGGAGGCGCCCGGCACC CGCGACCCAACGCGGCTACGGCCCGTGTACGCGCGCGCCGGGCTGCTGAGCCAGGCCAAG GGCTCGGCCTACCTGGAGGCGGGAGGCACCAAGGTGCTGTGTGCCGTGTCGGGCCCGCGA CAGGCCGAGGGCGGCGAGCGCGGCGGCGGCCCGGCCGGAGCAGGCGGCGAGGCCCCGGCC GCGCTGCGCGGTCGCCTGCTCTGCGACTTCCGCCGCGCACCCTTCGCGGGCCGCCGGCGC CGCGCTCCCCCGGGCGGCTGCGAGGAGCGTGAGCTGGCGCTGGCGCTGCAGGAGGCGCTG GAGCCGGCTGTGCGCCTGGGCCGCTACCCGCGCGCGCAGCTCGAGGTGTCGGCGCTGCTG CTGGAGGACGGTGGCTCGGCCCTGGCCGCCGCGCTCACCGCCGCCGCGCTCGCCCTGGCC GACGCGGGCGTGGAGATGTACGACCTGGTGGTGGGCTGCGGCCTCAGCCTCGCGCCGGGG CCCGCGCCCACCTGGCTCCTGGACCCCACGCGGCTCGAGGAAGAGCGCGCCGCCGCCGGC CTCACCGTGGCGCTCATGCCTGTGCTGAATCAGGTGGCCGGGCTGCTGGGCAGCGGCGAG GGCGGCCTGACAGAGAGCTGGGCGGAGGCCGTACGCCTGGGCCTCGAGGGCTGCCAGCGC CTCTACCCCGTGCTGCAGCAGAGCCTGGTGCGGGCCGCCCGCCGCAGGGGCGCCGCCGCC CAGCCCTGAACCAGAAGCCTGAGCAACTACGGACGCAAGCCGAGGACCGTGCTGCCGCCG TCCACGAAAAGACCCGCGCCATCGGCCTCCAGTTTGCGTCGAGAATTCCTGGAAGGGCCC TGATATGACTGTGGTTGGACTGACCTGACTGCCAGATGGTGGGACTTGGTCTGGAGCAGG GACTACTTGGAATGATAAAGGCAAAACTCAACAGCCCCTGGAGCTGCGCTTGTGGTGGAG CTGGACCCTGAAATTACCTGGACCTTTTTTTTAGAGACAGGGTTTCTTTCTGCAGTCTCA AACTCCTAGCCTTGATTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGACTACAGGTG CATGCAACCACACCTGGCTAATTTTCTTTTCTTCTTTCTTTCTTTTTTTTTTTTTTTTTT TTTTGATGGAGTCTTGTTCTGTTGCCCAGGCTGGAGTGCAATGGTGCAATCTTGGCTCAC TGCAACCTCTGCCTCCTGGGTTCAATCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGG ATTACAGGCACATGCCTCCATACCGGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTT CGCCATGTGGGCCAGGCTGTTCTCGAATGCCTGACCTCAGGTGATCCACCCGCCTTGGCC TCCCAAAGTGCTGGAATTACAGGTGTGAGCCACTGTGCCCAGCTGAGTAAATTTCTTGAT TGCACAGAATGTACGGTGATATTGGCGGACTTAAGGACATCGAATTGTTTATCAGGAATA AAGTATTATGTGTGTTTTCTGCGGCCCTGGATAATGCTGTAGCATTCAGGGTCGATTGAG TAAAAAAAATGTAGAGATGG OMIM ID 606490