| Entrez gene ID | | 1208 |
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| Official gene symbol | | CLPS |
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| Full name | | colipase, pancreatic |
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| Aliases | | ,-, |
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| Gene summary | | The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. [provided by RefSeq] |
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| Location | | Chromosome: 6 Locus: 6pter-p21.1 |
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| Gene position | | 35765102 - 35762760 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 2343 bp |
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| Gene sequence |
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