Entrez gene ID | | 135250 |
Official gene symbol | | RAET1E |
Full name | | retinoic acid early transcript 1E |
Aliases | | ,LETAL,MGC125308,MGC125309,RAET1E2,ULBP4,bA350J20.7, |
Gene summary | | Members of the RAET1 family, such as RAET1E, are major histocompatibility complex (MHC) class I-related genes located within a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteins contain MHC class I-like alpha-1 and alpha-2 domains. RAET1E and RAET1G (MIM 609244) differ from the other RAET1 proteins (e.g., RAET1I, or ULBP1; MIM 605697) in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a ligand for NKG2D (KLRK1; MIM 611817), which is expressed on the surface of several types of immune cells and is involved in innate and adaptive immune responses (summary by Radosavljevic et al. (2002) [PubMed 11827464] and Cao et al. (2007) [PubMed 17470428]).[supplied by OMIM] |
Location | | Chromosome: 6 Locus: 6q25.1 |
Gene position | | 150212097 - 150209601 Map Viewer |
Gene orientation | | minus |
Gene size | | 2497 bp |
Gene sequence |
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OMIM ID | | 609243 |
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