Entrez gene ID | | 1369 |
Official gene symbol | | CPN1 |
Full name | | carboxypeptidase N, polypeptide 1 |
Aliases | | ,CPN,FLJ40792,SCPN, |
Gene summary | | Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq] |
Location | | Chromosome: 10 Locus: 10q24.2 |
Gene position | | 101841642 - 101802065 Map Viewer |
Gene orientation | | minus |
Gene size | | 39578 bp |
Gene sequence |
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OMIM ID | | 603103 |
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