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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CRH (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1392 Official gene symbol CRH Full name corticotropin releasing hormone Aliases ,CRF, Gene summary Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq] Location Chromosome: 8   Locus: 8q13 Gene position 67090846 - 67088612  Map Viewer Gene orientation minus Gene size 2235 bp Gene sequence >CRH:complement(18953013..18955247):Length=2235 TCGTTCCTTGGCAGGGCCCTATGATTTATGCAGGAGCAGAGGCAGCACGCAATCGAGCTG TCAAGAGAGCGTCAGCTTATTAGGCAAATGCTGCGTGGTTTTTGAAGAGGGTCGACACTA TAAAATCCCACTCCAGGCTCTGGAGTGGAGAAACTCAGAGACCAAGTCCATTGAGAGACT GAGGGGAAAGAGAGGAGAGAAAGAAAAAGAGAGTGGGAACAGTAAAGAGAAAGGAAGACA ACCTCCAGAGAAAGCCCCCGGAGACGTCTCTCTGCAGAGAGGCGGCAGCACCCGGCTCAC CTGCGAAGCGCCTGGGAAGGTAGGGAGCGCCTGGACGGAACACGCCACCAACTTTGCGTT GCCTGAGCTGCCGCGATGTGCGCCGCGGAGCCGGCTGCCCCTGCCTGTGTACGTGTGTAT GCATGTGTGTGCGTGCGTGTGTGTGTGTGTATGCATGTGTGTATGCGTATGTGTGTGTGT GTATGCGCGCGTGCGTGCGTGTGTGTGTGCGCGCGTGTTCGCGGACTATTCCTTAAGATT ACAATAGTAGCTGGGATGTGGCAAAAGCAAACTTAGACGGCTGCTCTTCGTTACCCGTGC TGCCAGTTGCTCCTTGCTGGCTGTGTAAAGGAGCTCCCCCACCCCCTTCTATCCTAACCC CCGAGATAAGGCAGCAAGGGCAGAAGTGGAGAGGGAGGACCATGAGGCAGTAGTTCTCAA TTTGGAAGAAAATGCTGAAATATCCGGAAGGGAGGTAGTCAGCGCGGGTGGGATCTTAAA TCTGTGGCTCTTCTCTAGGATCGGGAAAATTAGTTTTGAGGATCGTTAGGAAGAGGACGC AGGGACCGTCCTTTCAGAGTCTAGAAAGAAGGGTCACTCCTGGCCGGTGAGCGCATGAGC TTAGGTGCGGAGCCCTGCAGGCGCCCCCTTTCCCCGCTCCCCAGGCGCTTCAGCACCGCG GACAGCGCCCATCCGAATCACTGAGGCCAAAGCCCAGCACGTCTAAGGCAGTCCCGTAGG AAGACCCCGTGTGCACCTCCCAGCTGAGCGAACTCTAACCAACTCTTTCTTTCTCTCTTC CCCTCTCTCATTCCGCCCTCCGCCCACCTCTGTGCCGCAGCGAGTGCCCCTAACATGCGG CTGCCGCTGCTTGTGTCCGCGGGAGTCCTGCTGGTGGCTCTCCTGCCCTGCCCGCCATGC AGGGCGCTCCTGAGCCGCGGGCCGGTCCCGGGAGCTCGGCAGGCGCCGCAGCACCCTCAG CCCTTGGATTTCTTCCAGCCGCCGCCGCAGTCCGAGCAGCCCCAGCAGCCGCAGGCTCGG CCGGTCCTGCTCCGCATGGGAGAGGAGTACTTCCTCCGCCTGGGGAACCTCAACAAGAGC CCGGCCGCTCCCCTTTCGCCCGCCTCCTCGCTCCTCGCCGGAGGCAGCGGCAGCCGCCCT TCGCCGGAACAGGCGACCGCCAACTTTTTCCGCGTGTTGCTGCAGCAGCTGCTGCTGCCT CGGCGCTCGCTCGACAGCCCCGCGGCTCTCGCGGAGCGCGGCGCTAGGAATGCCCTCGGC GGCCACCAGGAGGCACCGGAGAGAGAAAGGCGGTCCGAGGAGCCTCCCATCTCCCTGGAT CTCACCTTCCACCTCCTCCGGGAAGTCTTGGAAATGGCCAGGGCCGAGCAGTTAGCACAG CAAGCTCACAGCAACAGGAAACTCATGGAGATTATTGGGAAATAAAACGGTGCGTTTGGC CAAAAAGAATCTGCATTTAGCACAAAAAAAATTTAAAAAAATACAGTATTCTGTACCATA GCGCTGCTCTTATGCCATTTGTTTATTTTTATATAGCTTGAAACATAGAGGGAGAGAGGG AGAGAGCCTATACCCCTTACTTAGCATGCACAAAGTGTATTCACGTGCAGCAGCAACACA ATGTTATTCGTTTTGTCTACGTTTAGTTTCCGTTTCCAGGTGTTTATAGTGGTGTTTTAA AGAGAATGTAGACCTGTGAGAAAACGTTTTGTTTGAAAAAGCAGACAGAAGTCACTCAAT TGTTTTTGTTGTGGTCTGAGCCAAAGAGAATGCCATTCTCTTGGGTGGGTAAGACTAAAT CTGTAAGCTCTTTGAAACAACTTTCTCTTGTAAACGTTTCAGTAATAAAACATCTTTCCA GTCCTTGGTCAGTTTGGTTGTGTAAGAGAATGTTGAATACTTATATTTTTAATAAAAGTT GCAAAGGTAATCATG OMIM ID 122560