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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CRYGS (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1427 Official gene symbol CRYGS Full name crystallin, gamma S Aliases ,CRYG8, Gene summary Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. This gene encodes a protein initially considered to be a beta-crystallin but the encoded protein is monomeric and has greater sequence similarity to other gamma-crystallins. This gene encodes the most significant gamma-crystallin in adult eye lens tissue. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq] Location Chromosome: 3   Locus: 3q25-qter Gene position 186262167 - 186256232  Map Viewer Gene orientation minus Gene size 5936 bp Gene sequence >CRYGS:complement(92751378..92757313):Length=5936 AGCCATTCCTGAATTTCTTTCAGCACTGGGAAAACCAGTCTATGCACCAAAAATGTCTAA AACTGGAACCAAGGTAAGTAGTCATATTGATTTTTAGCCTACCCGCTTTTCACCTAATGA TGCATTCAACACACAGAAAAGCTTTTGCTTCTTTGCCTAGAGGTGAGTATGATAGTGGTT AGAGAACTGGGATTGAGAGAGAAGATTAAGAAATGCTTATTATATTTTCCACCCTTAACA GAATTACCGAACACTTTATTAAGGGTTTATCTTTATGTATGGTGCTATGTTAAATACTAT ACAGGTAATTTATAAATATCATTATTATTTCTGCCTTCTAGCAACTAATATTCTATGCAA CTGATATTCTCCATAGGAATAAGGCATGCTAATGGGGATTATATTGAGCAGAAAACTTTT AATAATCAATTAAAATTTTGTTTTCTGAAATTTAGCCTCAACCATTTGTGTTCTAAAAGG CCAAAGTGGATGGGCCAATCAGGTGAATAAAGTCCTACATCTCTCTTCCATTCAAGCAAT TATTTTTACTCGTTCCTCAAATAAAGTGCTCCCTTACAGTCAGAAAATTGCCTCTAAAAT ATTTAACTCACAATTACTGGATTGGAAATTATTCTTTCAGGTAGGGCTTTGGGAATGAGG GAATATGCTTTCATTTTCTTTTTTGCGCTTCCACTGATGAGACAAAACTGCTGCCTGATT TTTACCCCCAGCTATTTGAAAATTTTCAAACCCATTGAATCCTCAAAGAATGGCAAAGAA ATGTTGAATGAATATTTGTATATCTTTCACTTATATTCTCCAGTTGTTGACATTTTGCCA TATTTGGTCTCTCCTATTTCCATCTCTCTTTATTAAACCATTTGAAAATTAGTAGCAGAT TTTATTATACTTTTGCCTTAAGTATTTAGGCATGTATCTCCTAAAAACAAGGGCATTTCC CTGTATAAACACTGTATCACTAGCATGTCCCCAAGAGTTATCATAAATATAATAGCTAAT ATTGAGACCATATTCAAATCTCCCCTGATTGTCCCCAGAAAAGTGCTTCATGGTGGACTT TTCCCCTAATACAGGATCCAGTGAAAAACATGTATTGTAATTGGTTGTCATGTCTCTTTA TTCTCTTTAGTTTTTTTTAGCCTCTCTAAAAATGTCCCTCTACCCTTTTTGTTGTTGTTC TTGAGACATTTTTCAAAGCCTAGGTTAGATGTCTTTTAGAAAGTCTTGCAATCTAGATTT GTCTAATTGTTTCCTCATGTTTAGATTCAGAATAAATATATTTGGCAAGAAAGCTACATA GGCAATGTTGTGTACTTCCTGTTGCATCAGGTCAGAAGGTACCTGTTAACTTGTTCTGTA ATTTATTAGTGCTTGATTTTTTTTTCATTGGAAAATAGAACTAATAATCATGCTTGTCAT TCAGGAGGTTTGGGGAGAAAAATTAGTGTCTTCAGTGCTCTGAGGTTCTTGAAAATATAC CATGCAAATCCCACTAAAAAAGAATTTTTGGTCCTTAGAGGAGGGATATCCATGTATCTT GAGGTAAAGCTGTTCTACAACCATCTTAGATGAAAACATCTGCTTTTAAAGATTTGCAGA GTAGTAATAGTGTACTCTTTTTTATTTATAGATGAGTCGTTCATTTAGTTAAATAACTTT TGCTTGCTAGGGTAAAGGAGATAGTAAATTATTTCTTACTTTTTCTCATTGCTTCTTCCT TTCCCACTATCTTGATAGCAGTTTAATCAGAGGAGTTATGGGCTTGGCAAAAGGAATAGA TTTTACTAAGTATGTTTTCATTACTTCTGGGATACTCAAGATATTTTTCTCTCTGCTGCA TTGGATTAGTAGGCCATTTTTCCAAAAATAAACCTGATAATGATAGGAATTTTGTAATAA TTTCTAGGAAAACTTTCTGCACATTTCTTTAGCCTTCTCTACAAAATATTTTGCCCAAAG GTCAAAACCTCTAGGCTGACAATAGCATGGATTTCATGGTTATTCTACAAAAAGAAATTG AGCACAGCTAGGTGCAACATTCTCTGGCTCTGAGATATAGAAGGTCTCCCACTGAAAGGA GAGCTTAGTCTTGGAGCTCAGTAATGATTCCATAGCAACAGGATGAGGGCTTTGTTTCAA CTTTTGGATGGTTGGCTGGTCTCCTGGGAGGGTGGACATCAGGTGACCGTATCAGGCATC ATGTATCTTTTTACTTAGCAGATATTGATAATTAGTCACGCAAATGTGCAGAAGGCAGTA AATGTGAGAAACTATGAAGTGAAATAGATGGTATTATTAACTTCATTTCCCATAGGATAT CTTTTGCAAAGGCTCTTTTTAGTGACTTGTTTGGTCAAAAACCAAAGGCAAATAGAACAT ATGAATTAAGGAGTTTAGAATCTATCCATTCTTAGAGAAGTTATTTGACTTTCCTAAAGA TCTCTCCACAGGTCATGAGGAAGAGCCCCTGAGGCTTAGGCCCAGCCTTGGTCATTGTCC AAGAGAGTAAGTGCTGCCATGTTAAACGAAGCTAACTGGGCAGGCAGAAAGACAGCAAAG GAAAATAAAGTGAACAATAGTTTACTCACCAGGAGTTTTGCACTGCAGCCCACCAGCTTG TCTGCAACTAACTTGTAACTAGGTAGTGACATTAGGCCAATCACTTAACTTCTTCATCTG TAAAAACTGTAGCAAAAGCTTATTGCTAATCATGAGTCAGCTATTCAACTAAGTACTTTA TCAACATCCCCTTGGACCCTCAGAGCATACCGTCTGCAAGAGACACTATCATCCTGTTTT GCCAATGAAGAGCTGTAGAGAAAGGTTCATTGCCCTGTCCAAGGTCACGTAGCAAGAAAG CAGTAGTATTGAGACTTTTCTTTTTTTTCTTCATCCGTAAACTGAGGTACCATATATCTA AATCTGTACTGTGCTAAGATGGGAAGGGAACTGAAACACATAAAGAAATTTGGGCAGGGG ATAAAGGAGAGGAAGTAGATGATTTAGGGGTGGGAAGGAAAAGGGACCCTTTTAGGGAAC AGGAAAGAGAATAATTGAGATAAATGGGAAGGGAAGGGAAAGATTAAGGTGGAGGGAAAC AATTATTAGTATATTAGTATCTAGATAGAAAGAACTACCCAGGATAGAGGAGAATGAGAT TTTATAGCTTTTTATGAGTCATTCTTCGTTTCTTCCTCTCATTCCCTCCATCTAATTAGT CACCAAATCCTGAAGTTCTTTACTGTTTTCTCATCATCATTCACATTGGAGTTGCCTTTT GGTTGGCCCTCATCATCTCTCACCTGGCCCACAGCAGCCATCCGTTTCTAGGCACACACT ACTAAGTCCAACTCACTCATAATCACCAAAGGGATTCCAGCATGATTCTGGTGTCATTTT TCTGGCTTTATTTTCTAGTACTTCACCACATATTCAATATGTACTGGACTTAATGAACTA CTTATTGTCCCTATAATGGGCCATGTTCTTTCACTTTATTCTTTTAAACATGTTTGTTCC TTTTCATTTGCCTCTGGAAAACACCTACTTATCCTTCAATGCTCAGCTCAAAGATCCTCT CAAGACAGTATCCGGCTCTGCTCCTTTCATCTGAAATGACTCACATAGTTTTCGCCCGTG AAATCCATAAAGTAAATCAGCCACAAGGTGGCGGCATAATGCCAGGTAATTAACGGTTCG AAGCATGACACCTGTGGTTTCAGTTTATAACCTAGCATTGATCTGAAATTCCATCTTAAA AAAAAAAAAGATGAAAAGATTGTGGAATTATTGAATAACAAGGGACAAGCTCTGTAGCTC ATTTGTAGTTTTCATCGTGGTTTTCAGGAACTGCTTGGTGAATCCTTGGGAGTTCCTAGG AACTCTGTCTCCTGTTTCAGCCAGAAAAGCTCTGAGAGTTGTTTTAAAGCCAGAACTTCC AGTCTGCTGTAGTCTTCAAATAGGAAGCTGAAGCTCAGAGAGGTGGCTGGATGAAGATAG TAAGGCTAATTGTAGAGAGGGAGCTCTGTAGTCCAGACTTACTGTTTCTGCTTTCACAGG GCTGCATATTTTTCAGTGCCATCAGAGACTTACCCCAGGCATTGTGGTAGAAACTTGATA AGCGTTGGAGGCAAAGAGGATTCTTATCATTTTGTTACTTTGCAACTACTCTGTTGGCAA TAAACTAATAATAAAGAACATGATATGATACATTTTCATGTATGAAAGCTCTACATCTAT CTAAAATAAGCTCTGTAAAGCTAAGGTTCATGCTTTATTTTTCTCTATGTATCCTCCATA TCACCTAGGAGTCATCTTCATGAAACAATTATTGAAGTCAAGTGATGGGCACAGAGGATT GATAGCTCAAATAAGGCTTGGTACTTGCCCTTGGAAAAAGTATGCTAGGATTCTGGTGGG AGGGGTAGACATATAAATGGATAATTTATAATATGATGTAAGTACAGAGAGCTGTGGGAA CATAAAGGAAGGAAAATGAACTTGAGTCTGAGACTGCTCACTTCTATTAGAGCCCTCTTC TGTTTTGCTTCATGTTCAGCCTTCAGGAAGAACTCATTTCTGTTGTTGACAACTGAAGTT GTCTGTCAGAAAGCAATGTTGTAAGGTGACGTACAGCTACATATTTTTCCTCAAAATTGA GGTGAAAGGAATTTCTAAAGTAGGCATTATGTTCTTAATTTTTATCTGTGAATTAAGCCA CCCAGCTCCTCAGCTCTTTCTCTGTTGGCCCTCTACTTCAGATTACTTTCTATGAAGACA AAAATTTTCAAGGCCGTCGCTATGACTGTGATTGCGACTGTGCAGATTTCCACACATACC TAAGTCGCTGCAACTCCATTAAAGTGGAAGGAGGCACCTGGGCTGTTTATGAAAGGCCCA ACTTTGCTGGGTACATGTACATCTTACCACAGGGAGAGTACCCTGAATACCAGCGTTGGA TGGGCCTCAACGACCGCCTCAGCTCCTGCAGAGCTGTTCATCTGGTGAGTCTGGGGACTG TGTACTCCCTCTGTTTCCCACGCCCTCTGTCCGCTTTCTCTTGCTTTTAGGTGAACATTT TCTTGAGTCTTCTCTACCTCTTAATGAGTAGCTGCTTGTTGGCTGCTGAGGCTTGAGTAA CATCTTAGAGCAGCTCATCACTAGAATGACTACACTAATTTCCAGGGTGCTGTCTCTGCC TCTTGAGTGTTTTGAAGAATTAATTTTTTCTTATTGAAAGTTAGCTGTTTTAGTCAGTAC ATGGTGAGATGGGAGTTCAGATCATCTAGCTTTCAAGGTGATAAGTTCTGAGCAATACTG TTCTCTAAGTTCTTGACCTGCTGGTGATTTCCATAATGGTTTCTGTTCATTTTCTCCTGT GTCTTTTCAGCCTAGTGGAGGCCAGTATAAGATTCAGATCTTTGAGAAAGGGGATTTTAG TGGTCAGATGTATGAAACCACCGAAGATTGCCCTTCCATCATGGAGCAATTTCACATGCG AGAGATCCACTCCTGTAAGGTGCTGGAGGGTGTCTGGATTTTCTATGAGCTACCCAACTA CCGTGGCAGGCAGTACCTCCTGGACAAGAAGGAGTACCGGAAGCCCATCGATTGGGGTGC AGCCTCCCCAGCTGTCCAGTCTTTCCGCCGCATTGTGGAGTAATGACATGAATGGGGCCA TATTCTTCCTGGGGCCCAAATGCTGGCTGGCCTTGTGGTCCAAATAGGCATCATCAATAA AACAGTTGGCATGCATCCCACTGCTGACTATAATGCCTCTCCTTAAATGCTTCTAGGGAC CAGCAATACAGTGCTCGCCACAGTGGGCAGTCACACAAAGCTACCCATCTGCCAGATCAC CAATCTAGATCTTTGTGCCAAACAAAATGAGATCTCATTAAAAGGTTAGAAAGTCA OMIM ID 123730