Entrez gene ID | | 1501 |
Official gene symbol | | CTNND2 |
Full name | | catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) |
Aliases | | ,GT24,NPRAP, |
Gene summary | | This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. |
Location | | Chromosome: 5 Locus: 5p15.2 |
Gene position | | 11904110 - 10971952 Map Viewer |
Gene orientation | | minus |
Gene size | | 932159 bp |
Gene sequence |
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OMIM ID | | 604275 |