Home

Search

Browse

RAGs

User guide

FAQs

Links

Questions

Contribute

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CTSL (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1514 Official gene symbol CTSL Full name cathepsin L1 Aliases ,CATL,CTSL1,MEP, Gene summary The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] Location Chromosome: 9   Locus: 9q21-q22 Gene position 90340974 - 90346384  Map Viewer Gene orientation plus Gene size 5411 bp Gene sequence >CTSL1:19505506..19510916:Length=5411 GGCGGTGCCGGCCGAACCCAGACCCGAGGTTTTAGAAGCAGAGTCAGGCGAAGCTGGGCC AGAACCGCGACCTCCGCAACCTTGAGCGGCATCCGTGGAGTGCGCCTGCGCAGCTACGAC CGCAGCAGGAAAGCGCCGCCGGCCAGGCCCAGCTGTGGCCGGACAGGGACTGGAAGAGAG GACGCGGTCGAGTAGGTGTGCACCAGCCCTGGCAACGAGAGCGTCTACCCCGAACTCTGC TGGCCTTGAGGTGGGGAAGCCGGGGAGGGCAGTTGAGGACCCCGCGGAGGCGCGTGACTG GTTGAGCGGGCAGGCCAGCCTCCGAGCCGGGTGGACACAGGTACCGCAGCCAGGCCGCGC CGCGCCGACTCAGGGCCTGGCCCGGCCAGACAGGGAAGCTCAGTCCCCGCACGCCAGACA GCGGTACTCCTGCTGGCGTCACCGCAAACATCCTCTGACCGCTACAGCCAGTGTGTGGCG CAGGCGTCATGTCCCCGGCCCTGCCACGCCTGGAGCCCTGGAAGCTGGCTGCAGGGCGCT GGCTTCCCGCGTGCGGCCATATGACCCCGTCCCTGATTTAGGGGAGCAGTTTGGGGTGTC GGCAGCACAGGCCCAAGTGAATGAAGGAGGGAGCAGTGCGTGCTCTCCTTCCCAGTTTTT CCTGGGAAAGCATTTCAGAAAGGTTTCATTTAAGGAGAGGTTGGGGCGGCGCGGTGGCTC ACTCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCGGATCACCTGAGGTCAGTAGT TCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTGAAAATACAAAATTAGAC GGGCGAGGCGGCGCACGCCTGTAGTTCCAGCTATTCAAGAGGCTGAGGAAGAATGGCTTG AACCCGGGAGGCAGAGGTTGCTGTGAGCCGATATCGCGCCGTTGAACTCCAGCCTGGGCC ACAGAGCAAGACTCCATCTCAAAAAATAAATAAATAAATAAATAAATAAATAAATAAATA AATAGGAGAGATTGGAAAACTTATCTCAGCTTTTGGTGTTTGTTAGTCAGGAAGATGTGT GAAGGCCTCCTAACTCTTGGGGATCTCTTTGTCCCTACTTGGGAATCCCACCTTATCATT AGTGAGGTTTTGCCTGGGCACGAAACCTGGATTTTTTGCGATTGGTACAAAACCTGGATC AACCGTTTCCCGGTTTCCTAGTTGTTGCCTTAAGCTTCTCACACACAAGGTAGTTTCATA CCGTTCTCATAACCTAAATTGTCATCGCATAAACTGTTTCAGCTCCTACAGCTCTGGACA GGCTGCTTTTCATTTTGGTGAGTCCATCCAGTACCTCCACGTGCCCTGTTTTTCTCCAGG CACATCCTTGGCCTCTTCCACAGTCCTTGGGTAAATGCTTGGGAGAATAATTTAAATATT TTTATTCTACCATGGTGGCCCTAATTTTTCAGGGGGCAGTAAGATGGCTTTTTAGGATTG GTCTAATCAGATCCTCATTTTTGTTCCCTTCCTAGGTTTTAAAACATGAATCCTACACTC ATCCTTGCTGCCTTTTGCCTGGGAATTGCCTCAGCTACTCTAACATTTGATCACAGTTTA GAGGCACAGTGGACCAAGTGGAAGGCGATGCACAACAGATTATACGGCATGGTTAGTGAA ACTTCCCCAGAAAGAATAGTCCTGGCTGTTGAGAAGTTTTAGTCAGAGAGTAGCTTCTAG AGGCCAGCTTTTACCAATAGCCTAATGTAATAACCTAATGGCGTGGATTATGAGCACAAT GTGGACATTCATCCTTGTTGTGTCTCAGTTTGGAGAACAGCATCCCCAGAGGTGTCAAGC CTTCCCTTGCCATGGTTTCTCTTCCATCTCTGTCTGCAGATTCACTTGGTGAGGATGAGT TGGGTTTTAGGTAGAAGTAAAGAGCATCAGTTACATGTTTGCCTCTAGAATGAAGAAGGA TGGAGGAGAGCAGTGTGGGAGAAGAACATGAAGATGATTGAACTGCACAATCAGGAATAC AGGGAAGGGAAACACAGCTTCACAATGGCCATGAACGCCTTTGGAGACATGGTAAGTGTG CTGTGGACTGCCGAGCTCTGTGCTTCCTCTCTTCGGTTCTTTACTAAGGTAATCTCTTGC TTTTCAACATTTTATTTCCTTTTCCTTGAAGACCAGTGAAGAATTCAGGCAGGTGATGAA TGGCTTTCAAAACCGTAAGCCCAGGAAGGGGAAAGTGTTCCAGGAACCTCTGTTTTATGA GGCCCCCAGATCTGTGGATTGGAGAGAGAAAGGCTACGTGACTCCTGTGAAGAATCAGGT GAGACAGTGTCAGGTTCAGACCTCCCATCTTCCCAGGAAAGCCAAGAAGTGATTGACATC TTTGTTTTGGTAGACTTTAAAGTGATGTACAGTTCACTTTTTAACAGTATTCAGATGTGT GAGCTGTTGTCAAAGTCTTATTATTTTTTTTTTGTGGATGACAGCTTTTTTTAATTCCCT TTTCAGGGTCAGTGTGGTTCTTGTTGGGCTTTTAGTGCTACTGGTGCTCTTGAAGGACAG ATGTTCCGGAAAACTGGGAGGCTTATCTCACTGAGTGAGCAGAATCTGGTAGACTGCTCT GGGCCTCAAGGCAATGAAGGCTGCAATGGTGGCCTAATGGATTATGCTTTCCAGTATGTT CAGGATAATGGAGGCCTGGACTCTGAGGAATCCTATCCATATGAGGCAACAGTAAGTGGA GCTCCTTGTCATCATTCCAGCTCAGCTTTTGGAAGGTGGACACTTTAAGAGATAACAGAT ACCTTTTTCGGAATTCATATATTAGGGCTGGGTGGGGTGGCTCACGCCTGTAATCCCAGC CCTTTAGGAGGCTGAGCCAGGCAGATGGCTTAAGCTCAGGAGTTTGAGACCAGCCTGGGC AACAAGGTGAAACCTTGACTCTATCAAAAATACAACGAAAATTAGCCGGCTGTGGTGGTG TGCGTCTGTGGTCCCAGCTATGCTGAGGTAGGGCGATTGCTTGAGTGTGGGAGGTGGTTG TGCAAATGCACTCTCCAGTCTGAGTGACAGAATGAGACCCTGTCTCCAAAAAAAAAAAAA AGTTCACATATTAGATGGCAGAATATATATCTGCAAATTGTCAGTACTGTCATTATAAAT TATTAGCCTTTGCACAATCCTGTGATTAGATGGGTAACATATAGCTGTTCTTGCTTCTAT GTAACGTGAAGAATATACAAGCCATTCTAAATATACACATTTCTCTATTGTGAAAAATGT CTTATGGAAGTAAACCCAGAGGTCTCATTGAAGAGACTGGAGTCAATTTTCAGTTTCAGA TTAACTAATAGCATTTCACTTCCTGGGATGATTTATAACAGTGGTGACTTGGAAATACTA AGCTGCACACTGCTGAGTGTTGTGGTTCTAACTCATGTTCTCCAGGAGGAGGACAGCAGT AATCAAGTCTTTTTTTTCCCTTTACCTTTGAAAGGAAGAATCCTGTAAGTACAATCCCAA GTATTCTGTTGCTAATGACACCGGCTTTGTGGACATCCCTAAGCAGGAGAAGGCCCTGAT GAAGGCAGTTGCAACTGTGGGGCCCATTTCTGTTGCTATTGATGCAGGTCATGAGTCCTT CCTGTTCTATAAAGAAGGTAAGCATATTTTTCTTTGTAGAAATTGATGCAGAAAAAGAGT ATCATGACATACGAGCATGATAGACTCTGGTTTGCAAGTAAAGTTCAGTGTAGATATTTA GGTGCTTAGCATCATAGTTGTTCATTCTGTACATGCAATATTTATACCTGATGTTTCCAT TTGACATTATGTTGCGTATATCTCCATGAATATAAGTACTTCATAACTTTTTATAAATAG CTATATTTACTGTGTAGTTTAATATACTTAAAATATTCTGCAATTGTTGGATTTTTATAA TTTTTCCAAAGATTTTTACTTCTATTATTAAATCCGAAAAGAGCCTTTTGATTCAAGGAT TTTAGTGTTCTGTGCTATTTTTTTAGATTGATATCCTAGAGTAGAATTACAAGCTTACAA AGAGGGGTCTTTTTTTCCTCTAGGAAAGCTTTTTTTTAATGAAGGATTTATGCTGATTTC TATTTCTGCTAGTTGTAAATGAGAGCTTAAATCCCTGGCCTTCTTATTGTTGTTAAGTAC TATCTGGAATGTGTGTCACTTCACTGAATTCAGAGATGCCTCATTCCCTGTGGGTGACAG GATGGGTTACTGTCATGTGTCCTCTGGAGCTTCTCACCCCAGCCCTCATTTTACCATCCC AGGCATTTATTTTGAGCCAGACTGTAGCAGTGAAGACATGGATCATGGTGTGCTGGTGGT TGGCTACGGATTTGAAAGCACAGAATCAGATAACAATAAATATTGGCTGGTGAAGAACAG GTATAAATTGCCAGAAATACTTACATTTGAAATTCAAAAGAGAATACTTATTTGCAAACA GTGTTTGGATACAGTTCCACATGCCCTTAGGCATACTTCTGAAATCCCCAGAAGTCTAAG TTGAACATATAATATTAATGTTTGATTATAAAAGTAAGAAACTGTCACAAATATCTTGGG AGTATGAATATAGTATTTGTTCCATTGTATAAAGGTGTATCTAAATCTGAACAGTTTTTA AATTCTGAGGCATATCTGGCTGCAAAGACATCCTATTGTTTTCCTGTCTCTGATCTGTAG TTCTGTGAAAGGTCACAGTTTGGAGGCTGGGATGGAAATTATGTCCAGGTTATGTCAAGA ATTTTTTAAGGATAAACAGGAACATTGCCTGTCCTGATTCTTTCTGTTAAGTCTATGGCC TCTGGCACAGTGTTTAAGTTGGGTGTTCCTGTTAATAACCCTTTGGGCTTTATTCTTTCT CTGAAATGGAAAACCTGCTCTTTTTTCAGCTGGGGTGAAGAATGGGGCATGGGTGGCTAC GTAAAGATGGCCAAAGACCGGAGAAACCATTGTGGAATTGCCTCAGCAGCCAGCTACCCC ACTGTGTGAGCTGGTGGACGGTGATGAGGAAGGACTTGACTGGGGATGGCGCATGCATGG GAGGAATTCATCTTCAGTCTACCAGCCCCCGCTGTGTCGGATACACACTCGAATCATTGA AGATCCGAGTGTGATTTGAATTCTGTGATATTTTCACACTGGTAAATGTTACCTCTATTT TAATTACTGCTATAAATAGGTTTATATTATTGATTCACTTACTGACTTTGCATTTTCGTT TTTAAAAGGATGTATAAATTTTTACCTGTTTAAATAAAATTTAATTTCAAATGTAGTGGT GGGGCTTCTTTCTATTTTTGATGCACTGAATTTTTGTGTAATAAAGAACATAATTGGGCT CTAAGCCATAA OMIM ID 116880