Entrez gene ID | | 156 |
Official gene symbol | | ADRBK1 |
Full name | | adrenergic, beta, receptor kinase 1 |
Aliases | | ,BARK1,BETA-ARK1,FLJ16718,GRK2, |
Gene summary | | The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q13.1 |
Gene position | | 67033905 - 67054029 Map Viewer |
Gene orientation | | plus |
Gene size | | 20125 bp |
Gene sequence |
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OMIM ID | | 109635 |