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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DBI (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1622 Official gene symbol DBI Full name diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) Aliases ,ACBD1,ACBP,CCK-RP,EP,MGC70414, Gene summary This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] Location Chromosome: 2   Locus: 2q12-q21 Gene position 120124504 - 120130122  Map Viewer Gene orientation plus Gene size 5619 bp Gene sequence >DBI:9873167..9878785:Length=5619 GCCCGAGCAGGGTTGGGGCGAGTGGACCGCGCCTCTAAAGGCGCTTGCCAGTGCAATCTG GGCGATCGCTTCCTGGTCCTCGCCTCCTCCGCTGTCTCCCTGGAGTTCTTGCAAGTCGGC CAGGATGTCTCAGGTACAGCGCGTGCACAGCCAGGCTGCGAAGGTGCAGCGGGCGGGAGG CCCGTTGGGGGCTCAGCCGGCTGCCAGAAGCTCTCGGGCTCTTTCCTTCCGTGCCCCTCA CTTGCTCATGGGCCCATGCCTAGCCCTGATTCGTTGGACAGAGCCTTGTGAGCGGGATTT TCCGTTTGGGGATTTCTAAATCTGCTGCCCACCCCGCAACTGCCGGAAAGTTGCCCATGG GGTGGACTTCGCTGTGTAGCGGGAGAGGGGTGGGAGTCGAGGGTGCTTGATGGAGAGATG GGGGAAGGGGTTGCACGGATTGGAGGAGCGAGGAGACTCAGTCCCCATCCCGAAGCACAG GGCAGGACGTCGCGGCGGAGTGGGGAAGCGAGGAGTCCGTGGCCGAGAGCTTGGAGGTCA GGGGAAGTACGGGGCCGGCTGCTCAGAGTGCGGGACGAGGAGAATCGCGGCCCGGGGAGA GGTGACCCAGGGGCCCCTCCCTTCTCTCCAGTGTAGACCCTTGTCTGAGACCGAGCTATG TGGGGCGACCTCTGGCTCCTCCCGCCTGCCTCTGCCAATCCGGGCACTGGGACAGAGGTC GGTGTTGAACGCGCGGGCCCCAGGGGGAGGGAGGGGACCAACGGGCTCCGGCGCTGACAC CGCGGCACTCATGCCCTGTCCCCTTTCAGCTGTTTCCAGCATACTGTGCCCCGTCTGTCC TCAGGCCAGGGCTTCGCTGCAGCCCCGGCCACTCCCTAGTGCCTGGCCCGGTGGTGGCCA GGCAGTTGGCCGCGCTGCTTCTCCCGCAGAGGGGACCCCCACTGGGGGCGAAGGCTTGGC CTGCCCTCTTCACTGCTGTATTTCCAGACCTGATGCCTGCGTTTGTGAGAGCTCTGGATA TATGGTTTTCGATTGAATGAGTGAACTGGAGGGGCTTCCCCTTCTTGTGTTGCTGAATCT TTCTAGCTGCCCTGTTGGGGCAGGGAGGGGCAGACACACTTCAGGGGCTGCATTGCCCGA AGGGTGCCACCTTTCCCACCTCTCCATCCCCGTAACTGGGCTGTCATCAGGCCACAGTAG GATTCTTACCCTCTCCCACCCAGAGGAGGCCCTCAATCCTCTCCTCTCCCTTCCATTTAG GCTGAGTTTGAGAAAGCTGCAGAGGAGGTTAGGCACCTTAAGACCAAGCCATCGGATGAG GAGATGCTGTTCATCTATGGCCACTACAAACAAGCAACTGTGGGCGACATAAATACAGGT ATGCAGAGCGGGGGTTGGAAGGGCATCTGCTCATCAAAGCAGGCTCAGCAGCTCAGACTG GAAGTCCCTGGGAACTTCACTCTCAAACTGCCTGAGGCCCTACTCTTCAGGTGGGGTATG GTGATGGTTCCTGAGGTGGAAAAGACCATGTTCCGGATTCTCAGTGTCTCCAGTAGTAAC AGAATTCAAATCCTGGTTTTAGAAGGTCTTTACTGGTTATCACCAGCAGCTACTCTCTAC TAGGGAAGAAGCAAAGGCTGCAGCTTGGAAAAGACTTGCTGAAGGCTCTCAGCTCAGTAG TATCATTGTTGAGCCGTTCAGCTTCTGCCCTAGATGGGCAGGATCAAAGTTGGAGCACTT TTTGGAGCACTTGACAGCCTGGCCAAGCCTGATGTCAGGAGCAGAGAAGCACCTGGTTTC TTGGGCTAGGTCAGAGCATTTCGCTAACAAGTCTGTGCCTTCCTGATGATAACTTTTTCC CTGCCCAGAAATCTTGGTGCAGATTTTGAGGCTGTGCTTTGGACTGTCATGTTCTGTAAT AACATCTTTCCTGCCTTGGGCAGGTTTCATTCTGTCCCTAAGTCCCTGAAACATGGGTGG ATACTGAGGCAACAGCGCAGTGCATTCTGTGCAAGGACTCAGGGTTATCATGGCAGCACA GAAGGGAGGTCTCCCCTGCCCCTGCTGAGGAAGAAGGCGAGCATGGTCCCTATTTCCGCA GTAGCTGGGGTGGAAGATGGAGCAGGTGGGCTGGCTGCCAACCAGCTGGAAGCAGGAAAT AGTACCCAGAATGACAGATCACAGGCAGTACCATATCAAACCCTGGGGTTCACATGGAGC ACTTAGTTGAAGAAGGTCTTATGGCGAAGGTGAGTTTTACAGTGAGTTCGTAAACTCTGT CCTTCCAGGGAGGGGAAGGAAAGGTGAAGTGGGGGAGGCCAGAGGTGCCAAGATGCTTTT CTGACAAACAGTATTTTCACAGAGACTGGCCTGTGCCCGTACTAGAGTTACCGATTTTCA CATGAGTCTAGATAGACTGGCATAGGAATCTATCACTTACTGATCAAAGAGGTGTCATCG GCTCTCTCTAGGGCTGTACTATACAGCCCTATTACACGATTATAAAACATGATAGTCCAA ACACGATAGTTTAGTATAATAGCCAGTAGCCACATATGACTATATAAATTTTAACTGAGG CTGGGCGCTATGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAAGCAAGCGAATC ATGAGGTCAGGAGTTTGAGACCAACCTGGCTAACGTAGTGAAACCCCATCTCTACTAAAA ATACAAAAATTAGCTGGGCATGGTGGCATATGCCTGTAGTCCCAGCTACTTGGGAGGCTG AGGCAGGAGAATCGCTTGAACCTGGGAGGTAGAGGTTGTGGTGAGCCGAGGTCGCACCAC TGCACTCCAGCCTGGGCAACAGAACGAGACTCTGTCTCTAAAAAAAAAAATTTTAACTGA AAATAGTTAAATAAAATCAAGTTTAGTCTTCATTCACAGGAACCACATTTCAGATGCCCA GTAGTCATTTCAGGTACTTGGTGTGGCAAGTGGCTCCTGAATTGGACATTGCAAATATAC ATGTACATTTCCATTTCCACCGCTTGGAGAGAGCTGTCGAGGAGTGCTATTCTAGGATCC TGATGATGACCACAAGGGCAGTTTGTTTCAGCTGTCCCTGGGAACACTTCCCTGAAAGCG CTCAGGGACATTTTCTCAGGCACAGTGCTCCAGGCTACGGACTCTGATTGTTCCCTGTGG CTTTGGGGCTGGGCATCGTAGTGAAATAGGACAACAGGGAGATGGTGAGTGTGTTTCCCA ACTGCAGATGACAACAGGTCTATAAGCATAAAGTCATCATATAACTTAAAGAAACCTTAC CCTCGGTGAAATCTCCCACAGATCAGCAAGAAATAGACTAACAATTCGGTAGAAAAATGG GGCTAGGATATAAACAGTTCATAGGAAAGGACACCTGATATCATTAATGATTAGGGAGAG AAATTGGGTAGCTAACAGCAGGGGTGAGAGAGAAACTTTATAGTATTTTCCTCTGTAGCT TTTGAATTTTAAGACATATGAATGGATTTTTTTTTTAATTGTAATTAAAGTATAATTTTT TTAAAAGAGAAATTTTGGAGTCATTTAACTTGTAAGACAAAGGCTATCTTGTAATAAGAA TACTGTTCTTCCTATTTGCTCTAGATTTTAAGTTTGGATTGGCATACATTGGTTTTCTTA GGGCAGAACCCACTCTACTAGACCTATTTAACCCCATGACAGAGCCTAGAAGGAACAGGT GTAATAGAAGATGGCATTTATGGCAAGAAGGTTGATCAAGTTCTCCATTAGAATTTGAAC CAGATCTAATGCCTTTTCTTCCCTTGTTTAAGAACGGCCCGGGATGTTGGACTTCACGGG CAAGGCCAAGTGGGATGCCTGGAATGAGCTGAAAGGTAATTGTTCTAATCAATTTCTCTC ATTTGTGAAACCCAGTAGTGAAAGAGTCTTCATTATGAAGTGTAAGGGAAGAGGAGAGAA AACAAAGTCAATGGGGCACGTGTGGGAAACCAGCCTGACCTGTGCCAGAATGGGAAAAAA CCGGGCCACCTACTTTTTCTCCTAACACCATTTATGCCTTTTCTAAAAGCACCATCTCTG AGCAGGAGCATCATCTAGAGAGGAGGGGCTGGGAACCAGGCCACTGAAAAATAGTTTGGG AAATGATGTAGTTGGCGTAGGCTTTGGATGTGTTCAGAATAAGGGGTGGTTTCCTGTCTG CAACTCCCTCTCCCCTACAAGGCCAGGCGGTGACCCCCTAACCCCAGTGGCCCTCCCCAG TTCCTTCCTAGCCAGAAGGATACATAAAAGAAGGGAATGAGCTAATGCATGGCCTGCCGC TGGCATCGTAGGCTCAGTGAATGGAGCCATTATATGCTAAGCACCAGCAGCCAAGAAGTA TCCAAGCTCGTACTTAATCACGTGCCACCTGCAGCAGCAAGACCCAAGAGTTGGCACCAA AGCTCCTGGCAGCATTAGTGTTCCTGCTGGCTAGTTTCTGAATAAGCCCTCTGTCCTTCT GCGAATGAGAAACCCTTGAATTCAGAAAGGGCCACAATACAATAAACACACTCCTAGGAT CTGCAAGTAACTGGGAAGGGAATGCCCATCTGCCTGCCCATTTTCATGGGACATTTCCAT ACCATCCTCAGGCCCCATGTACTCTCCAGTGCTTCAGAACAAGCTCTGAGTTCCAAAGGG TCTCTATCCTTCACCATAGAATCCAGGAAACTGGGTGTCACTGTCTCTGAGGGATACATT CAGTGTCCTTTCTACTGCAGCAAGAAGACAAAGATTTGTCTCATTCCCCTCCAAGAAGCA GCCACTTTTGGTCAGAGTTCCTGAAACTTTTCTCATAGCCTCTCTCTGGGGAGAAGAGGG TGCCTGGCTTTGCTTTTTCACTGCCAGCTTAACAGCTCTGGAAGATAGGAGCCCAAAACA GAGACACTGAAAAGGCCAAAGCCAATATCAGCCACGAGAGTTAGCAGGACCAGTAAAGTC ACCACGATGACAGTTTCCTACCTGTCTGGAGGGTGGCACCTCTCTCCCAAGGCTCACAAT GGCCATTCCCCCAGGACAGGTGGGGGACGCAGGTGTCCAGCAGATGGGCGACAGATCTTG GCCAGCCCCACCAGGCTTTCTGAGCACAGTTGCTTATGGAGCATTCACTTCGGGCCAGGT TCTGTGGATACTGTCTCCTGTAATTAGTAGAATCTCAACTTTATTAAGTGAGAAACTGAG CCTAGGAGAGTTACAGCAGAGCTGCCTGGGGCTCTGGAGGCTGCTTGTTTCCTACCATGC TACCTCCCTGACACATAATCCTGTCGATTCCTTACAGGGACTTCCAAGGAAGATGCCATG AAAGCTTACATCAACAAAGTAGAAGAGCTAAAGAAAAAATACGGGATATGAGAGACTGGA TTTGGTTACTGTGCCATGTGTTTATCCTAAACTGAGACAATGCCTTGTTTTTTTCTAATA CCGTGGATGGTGGGAATTCGGGAAAATAACCAGTTAAACCAGCTACTCAAGGCTGCTCAC CATACGGCTCTAACAGATTAGGGGCTAAAACGATTACTGACTTTCCTTGAGTAGTTTTTA TCTGAAATCAATTAAAAGTGTATTTGTTACTTTAAATAA OMIM ID 125950