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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DCLK2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID166614
Official gene symbolDCLK2
Full namedoublecortin-like kinase 2
Aliases,CL2,CLICK-II,CLICK2,CLIK2,DCAMKL2,DCDC3,DCDC3B,DCK2,DKFZp761I032,MGC45428,
Gene summaryThis gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q31.23-q31.3
Gene position151000080 - 151178609  Map Viewer
Gene orientationplus
Gene size178530 bp
Gene sequence
OMIM ID613166