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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DIO1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1733 Official gene symbol DIO1 Full name deiodinase, iodothyronine, type I Aliases ,5DI,MGC130050,MGC130051,TXDI1, Gene summary The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence. [provided by RefSeq] Location Chromosome: 1   Locus: 1p33-p32 Gene position 54359861 - 54376759  Map Viewer Gene orientation plus Gene size 16899 bp Gene sequence >DIO1:24331779..24348677:Length=16899 GAGCTTACTCTGGCTTTGCCGAGATGGGGCTGCCCCAGCCAGGGCTGTGGCTGAAGAGGC TCTGGGTGCTCTTGGAGGTGGCTGTGCATGTGGTCGTGGGTAAAGTGCTTCTGATATTGT TTCCAGACAGAGTCAAGCGGAACATCCTGGCCATGGGCGAGAAGACGGGTATGACCAGGA ACCCCCATTTCAGCCACGACAACTGGATACCAACCTTTTTCAGCACCCAGTATTTCTGGT TCGTCTTGAAGGTCCGTTGGCAGCGACTAGAGGACACGACTGAGCTAGGGGGTCTGGCCC CAAACTGCCCGGTGGTCCGCCTCTCAGGACAGAGGTGCAACATTTGGGAGTTTATGCAAG GTCAGGAGGCTGCCACACACTTGAGGGGTGCTTGAAATAGCAGTGGTAGAGGGGGATGAA GAGATGGGTTGGAAAGTCCTGAATTCTCCTACTACTTTTGCTGCTCCTTTTGGACCTTCT TGTCCTCTTCCTGCTTCCTGAAACTAGAACTTCTTGTGGATTGTTTCTCTAAGTAACATC ACCACCTTCCCAGGCACTCAAATCACAAACCATCCAGTCTGGCATTTCAGCCCCTGGAAC ACTGCTCTTACTGTACAGGCTGATCTGCCTGGGCTGCTCTTTGCCCACCTCTCTGCCTGG TTAACTCTTGTTCAATCTTCAGACTGTTGCTCAATGACGCTTCTTTCGAGAAGCCAAGCC CAACTCTCCCATACTAGGCTACCCTCTCTCATCTGCCTGCTTAACATCCTAAACTTTTCT TTATTACACCTGTCGCGGTTTGTAATTATGTACGGCTGGCTAGGATTCATGTCTGCTTCC CTCACTAGTCTGCAAACTCAATGCAGGTCGAGACCATTGCTCTCACCCACTATTACACCC ATGCCTGATGGTGGCACATGGTAGCTGCTCAGTAAATACTTGTTAAAGAGCTCTCGGCTG GGCGTGATGGTTCACGCCTGTAATCCCGGCACTTTGGGAGATTGAGGCTGGCAGATCATG AGGTCAGGAGTTCGAGACCATCCTGGCCAACATGATGAAACCCCGTCTCTACTAAAAATA CAAAAATTAGCCAGGCGTGGTGGTGTGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGG CAGAAGAATCTCTTGAACCCCGGTGGCGGAGATTGCAGTGAGTCAAGATTGTGCCACTGC ATTCCAGCCTGGGCAACAGAGTGAGACGCTGTCACAAATTTAAAAAAGTCTCAGTTTTCT CTCTCTAACTCCATCCACTCCCCAGTCCAGGAAAACCAGTTTCGTCGACTTGAGTTCTTG ACCGTTCCAGTTTTCTCTTTTTTGTCCTCCCAGCTTCTCTTCCTGCCAGAACTTCCTTCT CCCCGACTTGCCCACTCAGCCAGCCCAGCTTGTGAATGGCTGCCAGATTGCTCTTCTCTG AGTACATACCAGCTCAACCACTTTCAGCAGCTCCCCTCTGCATTTAGGATGAAGCCCAGG CTCAGCCTTGGATTCCAGGTCCTCCCTGGTCAGGCTCTAGCTTTTCTTCTCAATTCTACC TCTGAGCTCCCCGCCACACTCATTTCTTTCGGACAAACTGTTGGGCCTTGTACATCTCTT GTACTTTCCCTTGTCTTTGCCTTTGCTGACATCGGCTGGTCAAGAATGCCCTTCCCCTCT CCATCGTCGTCTATATCCCCCTCATTCATGTGGGTCCAGCTCTCCTGACACCTTGTCCTC CATGAAGCCACCTCAGCTTCCTACAGCTAGGCATGTGCTCTCTCCCTTCGGCTCATGGCT CTCTGTCTGCACCTCTCCTTGGACACTGCTGCTTCCTGCTCAGCACCTGGTACCTAAGCA CAAGTCTTATTTCCCTGCCCAGTGGAGAGCCTCAGGAGAGGGTGTGTGTCTGATTTATCT CTGGATTCCTCAGCATGCTCGGCCCAGGGCCTAGATGCAGCAGGTAGAGAAGGCACCTGA GGCAGTTGGTTTATTCCGTGTTTTTCTTGTTTTTCTTTTTCTCTTTTTTTTTTTTTTTTT TTTTTTTTGAGACAGAGTCTCACTCTACTGCCCACGCTGGAGTGTAGGGGTATGATCACG ACTCACTGCATCCTCGATTTACCAGGCTCAAGCCATCCTCCCACCTTAGCCTCCTTAGTA CCTGGGACAACAAGTGCACACCACAATGCTCGGCTAATTTTTGCATTTTTTGTAGAGGTG GGGTTTCACCATGTTGCCCAGGCTGGTCTCGAACTCCTGGACTCAAGTGATCCACCCACT TCGGCCTTCCAAAATGCTGGGATTACAGGCATGAGCCACTGTGCCTGGCCTATCCTGTGT TTTTGAAAGAATGTTCTTTAGAACCTAAGTTCCACAGATATGCTTTACTATGTAGTGTTG CCTGGTCAAAGTAGTTGGGAAACCCTGAATACTATATCCCCCTCCTATGCAATTTCATGT GCAATTTCATGTGCACATGAGTGTATGCACATGAGGAGTTTACAGTTCCATAGAACAGAT GGAGGTAATAAACAAATCCTTACAGTCCTATGAAATGGGGGAGGCTATAAAAAAATAGAA CTTTTGCCTGGAGGACTTGGAAGTTTTCCTGGAGGAGGTGGCTCTGGAACTAGGTCTTGA AGAATGAGTCAGATTTTTGTAGCCTGACAAGGAAAAAGGGAAGAGTGTTTTAGAGGGGAA GGCAGGAGCTTCTTTTGTTTTGCTGTTCATTCATAATTTTAAACCACAGTGCACAAATGA CCTCAGTTTATTCAACAAATGTTCACTAATTCCATTGGTAGTAAGAGCAATGGTAATAAC TAACTTACCACATGCCCATGTGCCAAGCACTGTAACAGAACCAGGCCAATTTGCTGAATG CCAGTCATCTGCAGTTCAGTTCCCTGAAAGCCAGCTTGCCTCATGGCCAATTCATGGAAT GTACTTGCATCATGTAACTGTCCACTTTCAGTGAGGCAGTTTACATTTTAAAGACTGTTG AATTTGGTCTGAGCCCCGTGGCTCACGCCTTTAATTCCAGCACTTTGGGAGGCTGAGGCG GGCAGATCACTTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGATGAAACCTCGTC TCTACTAAAAATACAAAAATCAGCCAGGCATGGTGGCATGCACCTATAATCCCAGCTACT CAGAAGGCTGAGGCATGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAG ATCGCACCACTGCACTCCAGCCTGGGTGACACAGCGAGACTCTGTCTTAAAATAAAATAA AATAAAATATAAAATAAAATAAAAACTGTTCAGTTTGTCTCTGCTCCCTGCTGCTGCAGC TGAGACTGAAAATTGGTAGGAGTGACCAGTTGCAGTGGCCCATGCCTGTAATCCCAGCAC TGTGAGCGGCTGAGTGGGAGGATTGCTTGAACCCAGGAGTTCAAGAACAGCCTGTGCAAC AGAGTGGAACCCTGTCTCTACAAAATATTTAAAAATTAGTGGGATGAGGTGGTGTGAGCC TGTAGTCCCAGCTACTCAGGAGGCTGAGTTGGGGGGGTCACTTAAGCCCAGGAGGTCGAG GCTTCAGTGAGCCATGTTCATGCTAGTGCACTCCAGCCTAGGTAACAGAGTTAAGACCTT GTCTCAAAAATAAATAAGTAAATAAAATTAAAAATTTTTAATGGTAAGAGGAGGGGACTG AAGCAAAAGAAAAATCTATTTGCAAAATAGAGTTTACTTTCAGCACATTAACCCAAAGTC CCCTGAAATCATAGGTACTAACAATACGGAAATAAACACCATGGGCCTCTGCCCTGGAAG GCCTCATAACTCAGAGTGAGAGATGGTGTCGTGACAGGGAAGCAGAGGGCACTGGGGGCA GGAACCCTGTTAAGAGTAGGGTAAGGAGGTGGCCAAGGGAAAGCTTCCTGGAGGAGAGGA TGGTGTGCTGATTGTCTAGGGACAGTGAAACCTTGGGGTGGGTGAGGAAGAGGGGAATGG AAAGCAGGGCAGGGCACAGAGGAGGAGCAGCAGAGGTCTGAGATGTGGAGAAGCAACATT CAGTTTGGCACAAGTGGGGTCCCAGAGGCAGGAAGGGGTGAAGGATGAGGCTGAAGGCAT CATCAGGAACCAGAGCTTACGGGGCCTTGTGTGTCGTAGCTGCAGGTTGACTTTATCCTG AGAGTACTGGTGAGTTCTGGAAGGGTTTCCAAGAGAGAAGTAAACATGATCAGTTCTGCT TATTAGAAAGACATTGGCCGAGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAG GCCGAGGCCAGCGGGTCACTTGATGTCAGGAGTTCGAGACCAGCCTGGCCAACCTGATGA AATCCTGTCTCTACTAAAAATACAAAAATTAGCCGGGCATCGTGGCATGCGCCTGTAATC CCAGCTCCTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGTGGAGTTTGTAG TGAGCTGAGATTGCGCCACTGCACTCCAGCCTGGGCAACAAAGCGAGACTCTGTCTCAAA AAAAAAAAAAAAAAAAGAGACATGTTGTAACTACTTTGGAAACCCACCAGGCCACCAAAA AGCTCTGTTGTATGCTTTGGGTATAAACTCTGAACTCAGAGCCAGAGACAGAGAGACGTG AAGAATCTTTACTGATAATCTAAAGCAACCGCTTCGTTTTTGAGATGCAAAAGTCCAGAG AGGTGAATGACTCGCTTAGAGTCACACAGTGAGTTCTTAGAAGAGCCAGAACTAGACTTC TGACTCTCAGCTCGTGCACTTGCTGCTACTGGATACGACAGCAGGAGCTCAGGGAAACTC TCAGCCACCTCCAGCCCTCTGTGCGTCCACACACGCACACACACACAATATACACACACT CTTGGACACACACAGAACAAAACATCGAGTAACTGGCATGGTGTGGCAGAAGGCAAGTTC TGGATGATTTACTTTCTGGATACCTGAGAGTTAATCTGAAATTGGCTTCATTTCAGCCCC TGTTTAAAATCTTCTAACGTCTTTCCAGCTGTACTTACAAGTGTTGTCCAATAACTATAA ATAGGATTTCTCTGCTGACAGATCCTGACATGGGGGTTAATTTACTGGTCTGGGCTGTTT TCCCATTTATACAAAGGAGTTGGACTTGATAGTCTTCACTGGATTCTCGAAATGGTGTTC TCTGCACTGTGGTCTGTGGACATGGGCAGGGTGCCAGCCCCCATGCACCCATCCTTTACC TCTCTGCTGCTGAGGAAAGCAGAGAGCTTAGTTTAAACTTTGCCCTCAATACTGACCACT GTACCCAACCACACTATAAATAATTAAACAAATGGCTCTGTCTCTTCCAGGGTCTGAATC AGTGGATGTTGAGTTTTTTTCCCAATTAAAAACAAAATTTCATACAGCTGATACTTAGAG TTGATCATGACCATAAGTCTTTTGGGTTCTTTATTTTTTATTTTTATTGAGATGGGGTCT CATGCTGTTGCCCAGGCTGGAGTGCAATGGCACGATCGTAGCTCACAGCAGCCTCATTCC TGGGCTCAAGCAGTCTTGCTGCCTCAGCCTCCCAAGTAGCTGGGACTAGACATGTGTCAC CACGCCTGGATAATTTTTTTTTAAGAGACAGGGTCCTGCTATGTTGCCCAGGCTTTTTGG GTTCCTACCTAAAGAGTGACAGAGTGACTCTCTGGGGTCATTGGAGGCCAGTGACCAGCC ACTTGGCCACAATTGACCTCTGAGCTGCCCTCCTGAAGCCTGGGCCTCCTTGTCACATGG GTGAGAAATCATAGTGCAGTCAACCAGCAGAGACTGAGGCCACTCAATGCCTCCTCAGGC CTTTTAAGAAAAAGTCTGACCCAAGGACAAGGAGAGGGGCTTCGTATGTCCAGTGAAACT AGTCTGCTTTCCTCTCATATGCTAAAAATTGAGAATATAAGCCAATTTTGTTTCTTCTTT TACTTGGCCACCAGGAAGCTCAGAGTCAAAATATAGCTCAGTTATAACAAATGCATGGGA CCTATGGCCTGTGTGTATTCCGTTTTCCCCTCCTGTTCTACACCTCCCAGAGGGGCATGA TTAAAAAAAATTCTGGCCAGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGG CCAAGGCCGGTGAATCGCTTGAGGTCAGGAGTTCAAGACCATCCTGGCCAACATGGAGAA ACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGTGCACGCTTGTAATCC CAGCTACTTAGGAGGCTGAGGCAGGAGAATTCCTTGAACTTGGGAGGCGGAGGTTGCAGT GAGCTGAGATCACGTTTTTGCACTACAGCCTGGGTGACAGAGGAAAACTCCATCTCAAAA ATAAAAAATAAAAAAATTCCATTTAATGTGTTAGTATAGGTGTAAGGAGCTTTAAATTCT TTGCAGAACACAGAGGGGGTATAGTTAACCAAATAAACCACATGTAAGTTAAGATGCCCT CTACTCCCCATCTATCTGCAAACCCTGTCAATTCTGCCTTCTCCCCAGCTCCACTGCCCC ACACTAGCTAGCCCAGGCGCCCATTTTCTCTCTTTTTCTCTTATAGAGACAGGGTCTCAT TCTGTGGCCCAGGCTGAAGGGCAATGGCACAATCACAGCTGACTACAGCCTCAACCTCTT AGGCTTAATGGACGCTCCAGCCTCAGCCTCTTGAGTAGCTGGGACTACAGGCACACCCTA CCAGGGCCAGCTAACTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCAGAGATAAGGTCTCA CTGTGTTGCCCAGGGTGGTCTTGAACTCATGGGCTCAAGCGATCCTCCTGCCTCAGCCTC CCAAAATGCTGGGATTACAGGTGTGAGCTACTGCATCCAGACCCATTGTCTTTCATGTAG ACTTCTCCAGTGCCCCCTAACTGCTTATCCCTCACTTTCATTTTCACTCTTAGTCCTTTC TCCACAGAGCAGCCAGAGTGATCTTCAAGTGTAAATCTGGTTATTACATGGCCCTACTGT AGCAGTCAGGTTCTGGCTTGTAAGCAACAGAAGCTCCCTCTGGTTTTCTTGGTCACACAC ACATATGTACATAAAGGAACATACTGGAAAGGTGTTGAGTGCTTTCCAGAAACAATATCA GCTGGTCTTGATTGGACTGTCTTTTAGCATCAATAGTTGGGCCTGGATCCTGCTGTCATT GTGGTTGCCATGGGAACCCATCACCATCCCTTACAGGAGCACCACAACTGGGCTGTGGAT GAATTCTGCCGTCTCAATGACTCCCAGAATCAAAGATCTATGTGGAAGGGTATAATTAGC CCAGCTGGGGTCACTGCCTGAGCCCTGGCTGCCAGGGGCAGAGTGCGAACCTGGCCCTTC TGTCTTCCAAAGAGCAAGGCTGGGCACACTGTTTCATAAATAGAATACAAAATAGGGAAT TCTAAGTAGGAAGGAGAGTTAGGAGTTGGGCAGCCAAAACTGCAACAAACAAGTCAGATA TAGTCAAGTGCACCTATAGTTCCAGCTACTCAGAAGGCTGAGGCAGGAGGATCACTTGAG CCCAGAAGTTCAAGGCTGTAGTGTATTATGATGGCACCTGTGAATAGCCACTGCATTCCA GTCTGGGCAACATAACAAGATCTCATCTCTCAAAAAAAAAAAAAAATGAAAAAGAAAATA TGCAATAATATTCACCACCCTTGCTTTATATTCCTATGATAGCCCACATACCTAGGATAA AATCCAGATTCTTTACAAAGGCTTATGGGAGCCTGCCTGCTCTGGTCCATCCCTAACACT CCAACCCTTCTCTTGTTGCTCTCTATGCCGGGTTCCTGCCAGTGGTTTTGTGGGGCCTTG AACACACCAAGTTCTCTCCCTCCTTGGGGACTCTGTGTGAGTCTCTTTGGCTAGAATCCC TTTCTCCCTTTTCCCATGGCTGGTTCTCTCCTGTTTTTCATTTCTCAGGTTAAATGGCAG CTCCTCAAAGGCCTTCCCTGCCCCGCCTGTCTAAAATAGGTAACTCCTTTATAGCCTCTC TCGTAACACTGATCACAATTTGAAACTTCTTCATTTACGCATTTACTTACTTTTTTTTGC CTGTCTCCCCACTAAGCAGACTTCAAACTGCACACAGCCAGAGAGCTGCTGGTCTCATTC TCTGCCGAATCCCCAGTGTGTGGCAGGGAGACTTGCATATTTTAAGTGCTGAATAAATAT TTGTAGATAGGATGAGAGTATACTACATTCTGGAGATTCGAGGATGAATGAGGAACAGGC CCTGCCCTCAGGGGACAATGAGTAGGGGGGTTTGGGGGTATGTGGACACTTAAACAGGCC ATGTCACAGTGCAAGACTAGCCATGCTCCAATAAATGTATGGTAAGGGCTCAACAATGTC AGCTCTGGCCGTAAGAAACCACAGGAGGCCAGCTGCTCCCCAGAGTTGTCCTTGGTCTAG GATGGGGAGTTACAGAAGGCTTCCACCCAGGGCTGGCTTCATGGACATGGGACCAGTGAA TCACACAGGGACCTACACTCAAAAGGGCCTTGTCCTTGGGATTTAATGTTCTGCAGCAGC TGTCTTGAATTTTTGTTGCTGTTGTTGTTTTTAGCACACCAGAGTTGTAAAGTATGTCTT GAAATTCTTCATAATTTTATCTTTGAATCTGCATTTTGTAAGTGAAACCCTACGGGACAA TGGAGCATGCCCTGAGGACTTGGAGCCTCTGCTTGCACAGGCTCCTGCCTTCCACAGCCT CCCTGCCCCTCCAGGACATGTTCTCTAAGGCCCACTCTCCCATCCCCAGGTGCTCCTTCC TGCTTCCACCCAGTGACTGCTGCCATCTCCTGACCCCAGAGTGGGCCTGGATACAGACAT GAGGAAGGTGGGGGTCAGGTGTCACGTCCCCCAGTGTTGCATGGCAGCTGTCCCCATCCC GGGCTCGCAGTGCCATAGTGCAATTCGCCAAGTGACTGAGGGTGGGGGAAGCCTCTTGCC CACCCTTTCCCCCATCAAGGTACCTAGTATGTTCCTTACAGAGGTTGCAATACCCTGTGG GTTGGGGTGGTGGGCAGGTGGGAAGGGGCCATGTCTGGCTCAACTTCTGTGATGCTGGGC GGGGCATGGCATGTTGGTCTGGTGGCTGGAGGGAAAGGGAAATGCACACACACTCGGTCT CTGGGGTGCTGGGTAGCTGTGAGGATCTGCTCTCACTCTATGAATACCCCAGGGGAGTAT GACATCAAATAGCAACTAAAAGACACGATGCCAGGTCAAGAGAGGGACTACAGAAGATTA GAAATGTCTTTGTATTTCAGGCTGGGCACGGTGGCTCAGGCCTGTAATCGCAGCACTTTG GGAGGCCGAGGCCGGCGGATCACTTGAGGTCAGGAGTCTGAGACCAGCCTGGCCAACATA GTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGTGTGCACCTGG AGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCCGGAGGCGGAGTTT GCAGTGAGCTGAGATCACACCACTGCACTCCAGCCTGGGTGAGACTCCATCTCAAAAAAA TAAAAAAGAAACGTCTTTATATTTTAATAAATTTAATGGCACTTTCCCCCACTTTTTGAA CAAGGAACCCTGCATTTTCATTTGGCGGCAGGCCCAGCAAATTATGCAGCTGGTCCTGCT CCTAGCATTCACTCTCTTTGTGGAGCTGCCTTCGGTGCCTCCCTACTTCATAGCTCAGGG AGGAGATACAAGCTCATAGCAACAGCTTATATTTATGAAGCACCTACTATGGGCCAGTAA CCAGTTTAAGCCCTTATCTCTATTAATTTATTTAATCCTCCTAACAGTGCTACAAAGGAT TATTATGCCCCCCTTGTGGATGAGGAAACTGAAGTGCTATGAATAGAAAGAGCACTGAAT TGAGAGTTCAGAAACCAGAATGTTCATTTTAACTCCTCACTGACCTGCTGTGTGACCTGG AGCAAATGTGTAAAACTCAGTTTCTTTGTCTATAAAATGGGGGGAAAAAATGACCAACCT TGCAGTATTACTAATCCCATCGCATGACAGAATGGATGCATACCTGCCTTATAAACTGCA TGAAAGGGACTCCTCTTATATTTAAACTGCTATGCGGCAACTGCAGGTGGTCCACTGAGA CCACCTAAAAAAACCTCTCATTTTAGAGAGGAGTAAACCAGCTCCAGCCCCTGCTAAGTC ATGCTCTCTAGGTGTCGGACCCCAGTGCCTAGGACCCATCCTGGGGTGGGGGGTAGGGGG AAATAAAAATAACAGAATTGAACATAGGAGTGAAAATGGTGCTTGTAAAAGAAAGCTGTG TGTAGGGTCTCAGTTTGTGATGGTTGTTGCTGTTTCAGGTAATAGGCCACTGGTGCTGAA TTTTGGAAGTTGTACCTGACCTTCATTTATGTTCAAATTTGACCAGTTCAAGAGGCTTAT TGAAGACTTTAGTTCCATAGCAGATTTTCTTGTCATTTACATTGAAGAAGCACATGCATC AGGTACAGAAAGATTCTCTGCCTCTTCTACCTCTTCCCACTGTCTTTTCTCTCTCCCTTT TCCCCAGGCCCCATCTCAAGGTTGGGAGGTGGAAGGAGGAAGAGGAGGGGAGAGGGAAAG AGCCACTATTCACTGAGCACCCACCACTCCCAGGCCCTGCACTGGGCTAACCTCACAGTC TGTGCTTTCAACCAGGGTACAGAGAGCAGAACACCTGGAGTGACAGGGTCTGGCTAGGAG AGGATTCTAACATTTTGATCGGATAAATAGGGAAGTCAAGGGAGAAGAACTGATTTGAAC ACATTTACAAAGAATTCAGACCCAAAATGTCACAGGTGAAATGACGGCCTTATGGCTATT TTTTTTTTTTTTTTTTTTTGAGATAGGGTCTTGTTCTGTCGCCTGAGCTGGGGCTGGAAT GCAATAGCACTCACATGGCTCACTGCAGCCTCAACCTCCTGGGCTAAATCGATCCTCCTG TCTCAGCCTTCCAAGTAGCTGTACTGCAGGCATACGCCACCATGCCCAGCTAGTTTTTTG TATTTTTTGTAGAAACAGAGTTTCACCATGTTACTCGGGCTGGTCTCAAACTCCTAGGTT CAAACAATCTGCCCACCTCGGCCTCCCAAAGTGCTGGAATTACAGTCGTGAGCCACTGCA CCCAGCCTATATTTGTATTTTTGAAAGAACACTGTGGTGAAGAATTAGGAGAAAAAATAG TACTTAAACTCAGTATGAATTAGAATCATCTGGAAGGCTGTTAAAACGCAGATGTCTGGG TCCCATTTCTAGTCCATCCACGCTGACGCCTAGGGTTTGCACTACTTAACAAACTTCCAG GTGACGCTGATGCTGTTAGTCTGGGGACACACACTTAGAGAACTACTGATCTAAACCCTT GCCTCTCCAAGTATGGTCTAGGCGCCAGCAGTCTTGGCATCCTGGGAGTTAGATGGACTC TCAGTTCCACCTTCGACAGACCGAATCAGAATCTTCCTATAACAAGGTCCCCAAATGATT CATGCACATTCAAGATCAAGGAGTGCTGGTTTATTGGACTATTTCACGTTGAAGAGCAGG GGTCTGGCAGACAGAAGCCCTGGGCTTCAGTTCTGGATCAATCACTAATTCCTGACGTGA CCTTGCACATTCAACCATAATGGGAAACCAGGCCAAATCATTGCCAAGGGCTCCTCTGAG AACCTCAGTTAAAAGTGAGGGGCTATTTAGTCTGCAGGAAGTGTGTGCTGTGTCAATGGG ACTCGGTGCCTGGCCTTTCTCTTGTAGATGGCTGGGCTTTTAAGAACAACATGGACATCA GAAATCACCAGAACCTTCAGGATCGCCTGCAGGCAGCCCATCTACTGCTGGCCAGGAGCC CCCAGTGCCCTGTGGTGGTGGACACCATGCAGAACCAGAGCAGCCAGCTCTACGCAGCAC TGCCTGAGAGGCTCTACATAATCCAGGAGGGCAGGATCCTCTACAAGGTGGTGACCTGGG GACAGGGGGCCCAGGGAGGGCAAAGGGGCCCAGGGAGGGCAAGGGCAAAGAGAAGGCTTT GCATCAAGCAGAACTGGATTCAAATCACCACCCAGCCACTTACCAGCCATGTGACCATGG GCGAGTGCTTTCACTTCTTGGAGTTCCTTCAATTTCCTCTTCTGCAAAATGGGAATGTTG GTCTCCACCTCACGGGGGATGAAATAATGCACACGAATGTCCCTAGCATTTGGACTGGAG CTGCATCCTCCCGGCTTCCTTTTGAACCCAGATGATGGCCCAGTCCTGGTCTGGTTTCAA ACTCAGAGACAGAGAATGTTGTTTTTGTTCTCTGTTTTTTGGGTTTCTTTCTTTCTTTTT TTTTTTTGAGACAGACTCTCACTCTGTTGCCCAGGCTGGAGTGCAGAGGGGTGACCTTGG CTCACTGCAACCTCCACCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAG CTGGGACTACAGGCGCACACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGT TTCACCATGTTAGCCAGGCTGGTCTTGAACTCCTGGCCTCAAGTGATCTGCCCGCCTTGG CCTCCCAAAGTGTTGGGATAACAGGCGTGAGCCACCGTGCCCGGTCTGTTTTTGTTTTAT GAACAATGTTCAGAGAGGGGAATTGACTTGTCCAAGGTCACGCTGGGCAAGGCTCTGATT TCAATTCTAAAGCCCTTGATCGGGTGGGCCAGAAATGAGAAGGTCTGAAGCTGCTAACAT TTGCGGCAGGCCTGAACCAGGGCTGGCGGGGTAGAAGTCTCAAGGGGAATGGAACCCGTG GTTTGGAGCTGGAAATGCTGGACGCAGGGATGTGCGGCAGAAATGCATTTCAGGCTCCCT TTCTTGTGATTGCTTCCTCTCAAAAGTTCCAGCCTGGTCAGGGTGAGGGAGGTAAGCACA GCCTCTGACTCTTTAGACACAGTTGGCTTGGCCTCCCTTAAGAAGGTAGAAACTACATTT TAAAGCTATTGAAGGGATTTCAAGCCTTGGAGAGCAGATGAAACCAAGTATGTGGATGCT CCTCTGTCCACAGATCAAGATCAAGCTGACCCTACCTATTCAGATAAAACAAGCAAAAAC TTGCAGGCAAATTCCCAAGGTGCAAGGGTCACAGTAGAAGAATGTGGGTCCTTCATCCTT TCCTGTACCTTGGGACATGGTTCAGGCATGATTGAGGCACCCTGGGCACTGAATCCCTAC CTTGGGTTAGGCCCTGTGCAAATACTGGAAACACAAAAATGAATTGAAAATGACTCATAC CTAGCCGGGTGCAGTGGCTTACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCT GATCACTTGAGGTTGGGAGTTGGAGACCAGCCTGACCAACATAGTGAAACCCTGTCTCTA CTAAAAATACAAAATTAGCCAGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTTGAGA GGCTGAAGCAGGAGAATCGCTTGTACCCGGGAGGCAGAGGTTGTGGTGAGCAGAGATCGC ACCATTGCACTCCAGCCTGAGCAACAAGAGTGAAACTCTGTCTCGGAAAAAAAAAAAAAA AAAAAAAAATGACCGGCCGGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGG CTGAGGCAGGCAGATCACGAGGTCATGAATTCGAGACCAGCCTGACCAACATGGTGAAAC CCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCATGTGCCTATAATCCCA GCTACTTGGGAGGCTGGGGCAGGAGAATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTGA GCCGAGATCGCACCACTGCACTCCAGTCTTGGCAACAGAGCGAGACTCCGTCTCAAAAAA AAAAAGAAAAAAAGAAAATGGCCCACACCCTTACTTCAAGGTACTCACAGGCTGAGGGAT AAGGAAGACCCAAGTAAGACTATTACAGTGTCCCAACTGCTGGGGGACTCCAGAGCAGGG GTCAGCACGCCTTTTCTGTATAGGGCCTGATAGTAAATATTTTCAACTTTGTGCCAAGTA ATCCCTGTCGCAACAATTCAATTCTGCTGTTATAGCACAACAGCAGCTGCAGACGACATG CAAATGAAAGCATGTGAGGCATCAGGACTAACCTGGCTCTCAGACTGTAAGTTTTTCAAC CTCTGGGGAAGGGTAGGCTTCTCAGAGGGGGCAGCAATTGCTTGGGCCTTAAAGGATAAG GAGTTGGCCTAGTGAGCACAGTGAGTGAAAATCACTGCGGTATAGGGAAGAGGGTGGGTG GAGGCACTGAGGCATAGTAGGGCAGAGTGTGAATAAACGATTGGAGACATTGGGGTTACA CAGGGGTCTCATTCTAGACCAAGGGGTTTGGTCTTCATCTTAGGGCAAAGGAGAGCCACT GACGGGTTTGGAGCAGGAAAGAGACATGATCGGACCTGTACTTAGAACGTTCACTGGCTC ACGGCTGTAACTCTAGCACTTTGGGAGGCTGAGCCGGGCAGATCACCTGAGGTCAGGAGT TCAAGACCAGCTTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAGTACAAAAAAATTA GCCAGGCGTGGTGGCGTGTGCCTGTAATCCCAGCTACTTGTGAGGCTGAGGCACGAGAAT TGTTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCAAAGATTGTGCCAGTGCACTCCAGCC TGGGCGACAGAGTGAGACTCTCTCAAAAAAAAAAAAGAAAAGAAAAAGAAAGTTCACTGG TTCCATGGCCGGGCGTGGTGGCTCATACCTGTAATCCCGGCACTTTGGGAGGCCAAGGCG GGCAGGTCACTTGAGGCCAGGAGTTCGAGACCAGCCTAGCCCACGTGGCGAAACCCTGTC TCTACTAAAAATACAAAAATTAGCCAGGCGTGGTGGAGTGCACCCGTATTCCCTGCTACT CAGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAATCAAG ATTGCGCCATTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAAAAAAGA AAAAAGTTCACTGGTTCCTGGTTGAAAAATGGACAGGAGGGAGCAGGGACTAAGGACTGG GGATAGCTGGGAGGGGTGGCAGCTGCCCAGGCTGTAGGATGAAAAGGGCTGACCTAGGGC AGTAGAACTGGAGAGGCAGAGATGGTTCTGAGGTAGGATGGGTAGAACTTGATGTGAAGG CTGGAGAAGATTAGGCCAGTCTGAAGGTCTGATTATGGAAGAAAAGCTTATTTGTACAGA ACCCTTCTCTTTTTGAAAGACTATGTCACTTTATGTCCTCTAGTTTTTCTACTTCTCTGT CCAACCTTCCTGTTAACTGCTGATGCCACTGTACACACTTTCTCAACCACCTCACGGTTG CATCTGCCATTGAATTAGCCATGCTGATGGCTCCTACACAGACATCATTTGACCACCTCT TGCAACTAACCTCCAGACCTACATGTTCCTTACAACTTGGAAATCCTTACAAGTTGGGAA TGCCTGATTCGTTTCTCTTGCAGGGTAAATCTGGCCCTTGGAACTACAACCCAGAGGAAG TTCGTGCTGTTCTGGAAAAGCTCCACAGTTAATCTGGACAGATACCTCAATTCTAGGTGA CCAACGGGAGGGCTTCTCAAGGCTTAGCTCTCCCTGAGACCCAGCTGGCTTTTACCCTTG ACCTGTGTCCCTAGCTGAATCACTAGCTCAGATTTTTCTGATCTAAGCAAACAACTCCCA GCTGAGGAATGCAGGCCACAGCACCCAATCAAGACAAATTGTTATTATCAGAAAATGAAG CAACACTTGAGCTGTTCAGGCCAGTTCCCTGTTGAAGAAACAGTTCCCTGTTGAAGAAAG TAGAGCCTGACACTGCTCCCACTTTGGAGACCACATTCCCTGCACACGGTCTTTGAGAGA GCAGTTGCACTCTACAGGCACACTTCTGAGGTACGGTATCTCTCTCCAGCCACTCTGATA CCAAGTAATTCAAGCTGGCATTCCTTCTATTAGGGAAATTCATTTTACCCAATTTGCATT TATGGAATTGATCATTTAAGACACTAAATTAGTTTTTAGAACCAATTATGGGAAGAATTC CAGTTGTTAGGAAGAGATGAGGAGTTGGAAGAGGAGGGATTAGAAACAGGAGGAGGCAGT CATCCTCTCCTTGCCAAAAGATTTAAACCTGTCCACATTGGTGGTGATGATGGGTGAGTT TCCATGGTAACACATCCCTAATTTTACCAGGGAAGAGGAGAGTACTCACTTTACCATCTT TGAATATATTTCATAGAAATCTAGCTCTCTGTACCCTGAAATCTTCCACTAGCCTCACTT TTCAACAGAGTCATCTAGAAGGGAGGGTTGGCTTCCCAAAAGCATAACCTTGACCAAACC AAACAATAGGCACCAGCAATGCTGTCATTCAGTTATGCAGAAGCTCATTTGTGAAATTCT GTTTCTCTGATTTCTTCGCAAGTCTCTTAATGGTCATTTGTGTTAGATTACATCAAACTG ATGGATAGCCATTGGTATTCATCTATTTTAACTCTGTGTCTTTACATATTTGTTTATGAT GGCCACAGCCTAAAGTACACACGGCTGTGACTTGATTCAAAAGAAAATGTTATAAGATGC AGTAAACTAATAACAGAATTATTAAAATATATCAGGCTA OMIM ID 147892