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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DOCK3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1795
Official gene symbolDOCK3
Full namededicator of cytokinesis 3
Aliases,KIAA0299,MOCA,PBP,
Gene summaryThis gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq]
LocationChromosome: 3   Locus: 3p21.2
Gene position50712672 - 51421629  Map Viewer
Gene orientationplus
Gene size708958 bp
Gene sequence
OMIM ID603123