Entrez gene ID | | 1795 |
Official gene symbol | | DOCK3 |
Full name | | dedicator of cytokinesis 3 |
Aliases | | ,KIAA0299,MOCA,PBP, |
Gene summary | | This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3p21.2 |
Gene position | | 50712672 - 51421629 Map Viewer |
Gene orientation | | plus |
Gene size | | 708958 bp |
Gene sequence |
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OMIM ID | | 603123 |
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