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Gene information for DPYD (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1806
Official gene symbolDPYD
Full namedihydropyrimidine dehydrogenase
Aliases,DHP,DHPDHASE,DPD,MGC132008,MGC70799,
Gene summaryThe protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p22
Gene position98386615 - 97543299  Map Viewer
Gene orientationminus
Gene size843317 bp
Gene sequence
OMIM ID612779