Entrez gene ID | | 1806 |
Official gene symbol | | DPYD |
Full name | | dihydropyrimidine dehydrogenase |
Aliases | | ,DHP,DHPDHASE,DPD,MGC132008,MGC70799, |
Gene summary | | The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p22 |
Gene position | | 98386615 - 97543299 Map Viewer |
Gene orientation | | minus |
Gene size | | 843317 bp |
Gene sequence |
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OMIM ID | | 612779 |