Entrez gene ID | | 1849 |
Official gene symbol | | DUSP7 |
Full name | | dual specificity phosphatase 7 |
Aliases | | ,DKFZp586F2224,MKPX,PYST2, |
Gene summary | | Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM] |
Location | | Chromosome: 3 Locus: 3p21 |
Gene position | | 52090461 - 52082935 Map Viewer |
Gene orientation | | minus |
Gene size | | 7527 bp |
Gene sequence |
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OMIM ID | | 602749 |
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