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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DYRK1A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1859
Official gene symbolDYRK1A
Full namedual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Aliases,DYRK,DYRK1,HP86,MNB,MNBH,
Gene summaryThis gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq]
LocationChromosome: 21   Locus: 21q22.13
Gene position38739859 - 38887679  Map Viewer
Gene orientationplus
Gene size147821 bp
Gene sequence
OMIM ID600855