Entrez gene ID | | 1977 |
Official gene symbol | | EIF4E |
Full name | | eukaryotic translation initiation factor 4E |
Aliases | | ,CBP,EIF4E1,EIF4EL1,EIF4F,MGC111573, |
Gene summary | | All eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methylguanosine cap structure, m7GpppX (where X is any nucleotide). This structure is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A (see MIM 601102), that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G (MIM 600495) (Rychlik et al., 1987 [PubMed 3469651]).[supplied by OMIM] |
Location | | Chromosome: 4 Locus: 4q21-q25 |
Gene position | | 99851786 - 99799607 Map Viewer |
Gene orientation | | minus |
Gene size | | 52180 bp |
Gene sequence |
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OMIM ID | | 133440 |
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