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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for EIF4EBP1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1978
Official gene symbolEIF4EBP1
Full nameeukaryotic translation initiation factor 4E binding protein 1
Aliases,4E-BP1,4EBP1,BP-1,MGC4316,PHAS-I,
Gene summaryThis gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq]
LocationChromosome: 8   Locus: 8p12
Gene position37888020 - 37917883  Map Viewer
Gene orientationplus
Gene size29864 bp
Gene sequence
OMIM ID602223