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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for EIF4G1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1981 Official gene symbol EIF4G1 Full name eukaryotic translation initiation factor 4 gamma, 1 Aliases ,DKFZp686A1451,EIF4F,EIF4G,eIF-4G 1,eIF-4G1,p220, Gene summary The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq] Location Chromosome: 3   Locus: 3q27-qter Gene position 184032283 - 184053146  Map Viewer Gene orientation plus Gene size 20864 bp Gene sequence >EIF4G1:90527429..90548292:Length=20864 CGGCGGCGCAGATCGCCCGGCGCGGCTCCGCCCCCTGCGCCGGTCACGTGGGGGCGCCGG CTGCGCCTGCGGAGAAGCGGTGGCCGCCGAGCGGGATCTGTGCGGGGAGCCGGAAATGGT TGTGGACTACGTCTGTGCGGCTGCGTGGGGCTCGGCCGCGCGGACTGAAGGAGACTGAAG GTAAAGCCGCCATGTCCGGGCCCGACCCGGCCCCCCCACCCCCTCCCCCCGCATCCGCCG CCATCCGGGCCGGGACCGGCCACCCTGCGCCGCCGCCCCGGCGCCCTGGCCCCGCGGCCC GACCCAGGGCCCCGGCCCGCCAGGGTCCCGATCCCCGGCCCACGTGTGCCTGGCCCGGCC GGGCCTGGCTGCTGGGTGGGGGTGGGGAGCGCAGGGCCGGACTATGCGGGCCCCGCGGGC TGGTAGGGCGCCGGGTTCGTCGCCGCGAAATGCCACCTCGGCCTGACCCGAGGAGGCCCG GCAGCCCACGGGCGCAGGCACCACGGCTCCCGGCCCGCCGCCCCCTCCCCCCTTCGCGGC CAGGCCGCCGGGAAGTGACACGTTGTTCTTTGGCACTGGCCCGCGCTGCGCAGGGAGGGC GCAGGGGAGGGAGGCGGTGGCGGCGGGCAGGGAGGAGCCCCCGGCCCCGCCCGCCCTCCG GGCCGACCCTCACTTGCCTGAAACCGGCTCCTCGACGGCCGCCGCCCGCCTGGCCTTTTA GGGCCTGACTCCCGCCCTTCCTGGCCTACACTCCTGGGCGGCGGCAGGCCTAGCTTCTGG CCCAGTGCGGGTTCCCCGGCGGCAGGCGTATCCTGTGTGCCCCTGGGCCAGGCCCGAACC CGGTGTCCCCGGGTGGGGGGTGGGGACGCCACGGCCGAAGCAGCTAGCTCCGTTCGTGAT CCGGGAGCCTGGTGCCAGCGAGACCTGGAATTTCCGGTCTGGTTGGTCTGGGGCCCCGCG GAGCCAGGTTGATACCCTCACCTCCCAACCCCAGGCCCTCGGATGCCCAGAACCTGTAGG CCGCACCGTGGACTTGTTCTTAATCGAGGGGGTGAGTGAGGGGTCTGTTTCAGTAGGTCA GGGGTTGGTTGGAAGTGATGCGGGTTTGACAGCATGTTGGTGGGGACAGGCTGTATCTTT TCTGCTTCACCCTCTTGGCATCTCTGGGACTCCGTATGGGACCCAGCCCTTGCATCAACC CTTTCACCGCCCCATTTGCCTTAAGCTTGGGTCCCTTCCTCTTCCTGAGCGCCACTCTTT CCCAACAGGTGCTGGGGGGACCCTGATGTGGCACCAAATGAAATGAACAAAGCTCCACAG TCCACAGGCCCCCCACCCGCCCCATCCCCCGGACTCCCACAGGTAATTAGGGAGGAATTA GCAGGGGTGGGGGTGGGGGAGACCAGGCAGTCTCCAGCCTCTGGATCTTCCTACCCCCAT CTGTGTCAGGGCAAAGTGCAGCCGCCTGCTGCCAAATTGAGACAGGGCCCCTGGGCTGTC CCCGGGGGCTGTCACGGGGAGGGGGTATGTGGATTGTTAAGGCTCTTGCCGCAGATCTGC TCCCCTTATTTCACCAGCTTGGGTTTCTGCCCCACCTGGGCTTCCCCTCTTGCTGAACTC TGGTCTCCCCTCTTCAGCCAGCGTTTCCCCCGGGGCAGACAGCGCCGGTGGTGTTCAGTA CGCCACAAGCGACACAAATGAACACGCCTTCTCAGCCCCGCCAGGTGAGGGGCTGTGGGG AGGGGAGTAGGGGACCTGGGTGGGAGCAGTGGAAAGCTTTGGCCAGTTTAGGTCTAGGAT GGAAACTGGAGGCCCCATACCTGGCCTTAATCCTCTGTGTTCTTTCATGCGGCTCTGCGC CTTGCCCTGTTGATTACTCACGGTGGCTGGTCCCTTGGATAGTATGTTGTCAATGAGGGT GGCATTACTGGGATCCTAGTGCCTCTGAGAATTGGGGGCAGTGCTTTGGGCCCTGCTGCC AGCTCTTGCTTTCCTATTTGCTCCTTTTACCGGAGGCTGCTATTGCTCTATTGCTCTCTC TGCTTTCTCTTTGGACTGTGGTGAGGTAAACACTCCAGCTGGTCCTTGCCTTTCTCTGTT CCCCAGCTTCTTCCTTACTAAGTGGGAGGATTCTTGTCCTGTCTTATTGCCTTCATTCCC TCCCCCCGCCATCACCTTGGGGGTAATTCTCTTCTTTCCTATCCCCATGTGCTCTCAGGG AGGATTCAGGTCTCTGCAGGTAATATCCCTTTCCCAACCCTGGACAGTCTTCTGGTCTCA TCCTTACCCTCCACCCTAGTCAGGGGCTAGACACAGGGAATGGGGATCTTCAGGGTAGTG ACTTGTTTGGTGTCCAGGTTCTCAGTTGGAGGCCGAGTGATGCATGTTAGGGGCTACATC TTGAAGAACGCGCATCTGGGGACTGGGATGCTGTTGCATGTTATGGTTAGCTCCTCATTA CATGCTGGTGGAGCAGTGCATGCTGGGGATATGTTGCCCGAAAGGGCCTTACTTAGGCAT GATGCATCTCGGTGTTAGGAAGCCTCTGCAGAGGGGTAGTTTGGTAGAGGTGACGTGTGT ATGCATGGCAGTGAGAGAGTAAATCTCTGCAGGATGCAAAGTGTACATCTGAATTTGGAG GTTTGGAGGGCATGTGTGTGTACAAGAAGCCGCTTAGCCATTTGGTCAAGTGGTCTTGGA AGGATTGGTCGCCATGTTCTGAAGCCCACAGTACTTCTTTCCAGGCTATAGAGACATTGT GGAGTGGCAATTTTTTGTCCACTTCCTTCTCTTTACAATGCCAACTGCTTTCCTCCCTCC TGACAGCACTTCTACCCTAGCCGGGCCCAGCCCCCGAGCAGTGCAGCCTCCCGAGTGCAG AGTGCAGCCCCTGCCCGCCCTGGCCCAGCTGCCCATGTCTACCCTGCTGGATCCCAAGTA ATGATGATCCCTTCCCAGATCTCCTACCCAGCCTCCCAGGGGGCCTACTACATCCCTGGA CAGGTGAGGCTGGGGGCTTGGAGCCTAGAAGCCACAGACCCCTATACCTCTCACTTAACT CACCCTGACCCTCCAGTTCCATTGCTTTTCCAGAGGTGGGACTTCCTTCTGGTCATTGCC CAGAGTTGGCTTGTCTTGTCTTGACCTATGTTCTTTTTGGAGTCTGATATGGAACTCATA GCTCCCTCAACTCCTTCTCTCCCTCTCCCCCTTCCCCACCAGGGGCGTTCCACATACGTT GTCCCGACACAGCAGTACCCTGTGCAGCCAGGAGCCCCAGGCTTCTATCCAGGTGCAAGC CCTACAGAATTTGGGACCTACGGTAAGCAGGGGAGGGAGTCAGAGGTGAGAACAAGCCCA AGGGAGCATCTAAACTCATCTGCTGATTTCTAAAGCAGAAGACCCTTCCCAGGCTTGGCT TCTGGTCTAAAAATGATAAGGTTAATAGGTGGTAGGGATTGGTGCTTAATATTTAACTGG TGTTGATTGTGGGGAGAAAATTTGATTTTATTGCCAGGAGAGTTAAGAGTCTTTCCCACA TCAGGGAATGTAGGATCAGGCACCAGCCTGAGAGCCTATTAGTAGGCTTTCCCTGTGACA CTTCTTCCATGGTTGGGAGCCCATGTAATGCAAATTTGGGAGGTTTTTGTAGCTATTTTT TATTTATGTTCTAGGGAAGGATTAGTCTGTTCTTTATGGCAGTGGCTTCCAAGTTTTTTG ATCACCTATCAGGAAAAGTTTTGAGTATGAATCTCTCATACATGTATGTTTTTGTTTATA TGTATGCAAAATTTAAACAAATACACTTGTGCTTGTCAAAAACAAGTGGAATTTAGGGAT GAAATTAAAGAATGTGCCCGGATCTTGCTTGTAATCCCAGCACTTTGGGAGTCAGGAGGA CTGCTTAAGGCCAGGAGTTTGAGACCAGCCTGGGAAACTTAGTGAGACCCTGTCTCTATT TTAAAATTTGAGGGGGGCTGAGCACGGTGGCTCACGCCTGTAGTCCCAGCACTTTGGGAG GCCAAGACAGGCGGATCACTTGAGGTCAGGTGTTCGAGACCAGCCTGGCCAACATAGTGA AGCTCCGTCTCTACTAAATTTTATTGTTATTATTTTAATTTTCTTTTTGAGACGGAGTCT CGCTCTGTCACCCAGGCTGGAATGTAGTCGCACAGTCTTGGCTCTCTGCAGCCTCCGCCT CTTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTG CCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGATGGTGTTTCATCATGTTGACCA GGCTGGTCTCGAACTCCTGGCCTCAAGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGA GATTATAGGCGTGAGCCACCACGCCTGGCCCTGTCTCAACTAAAAATACAAAAATTAGGC CTGGTGATGCACTCTTGTAATCCCAGCTATTCGGGAGGCTGAGGCAGGAGGATCGCTTGA ACCCGGGATGTGGAGATTGCAGTGAACCAAGATTGTGCCACTGTATTCCAGCCTGGGCAA TAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAATTAAGGGGAAAAAAGAACTCACCCAC TTTGGAGATAGTTTGCTTTAAGGAATTAATTTTTCTTCATCTTGAGCCTAGTTCATAATG TTACTTTGTTTCTTTGCCCCTTTGTAAAGGGCTGGAGACAGGAACTAGACTCAAGTTAAA TGGAACAGGGTTGGCAGATCTCTTTCTCTCATTACCAGCCAAAGACCTGGTTCTGTTTCA GGTTCAGAGTATGTGTGTACATGTTGATAGCGGGTGGGGTACACACACGAGAGTAACTTG TACGGTGGAAGGACAGACATAAGTCCTCCTGGTCACTGGTGTGTGGTAGGAAAGAGTGCC TGCCTACGAGGGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTGTGTGT GTGTGTGTGTTAGGAATTCTTGTAAACGCAGTTCAGACTGGTTCCCCAGCTTTGACAGAC ACCTAATTCCCTGGGGGAGGAGGGCAGGGCAGGGCAAGGCAAGGGGCCGGCTGTGGGTGG TGAGAGGTTTTGGGGTGGGAGGTGTCAGGCAGGCATTAGTATATGGTTGGGCCCTGACGC TACCACCATTCTTCTCCGTCCCCCCTCCCCCAAGCTGGCGCCTACTATCCAGCCCAAGGG GTGCAGCAGTTTCCCACTGGCGTGGCCCCCACCCCAGTTTTGATGAACCAGCCACCCCAG ATTGCTCCCAAGAGGGAGCGTAAGACGGTGAGTAGCAGTGAGGGGCTCCGGGACATCTGG GAAGGGGAGAATCAAGGTCAGGTGCTGCTGGGACATTGTGCCGGAAAGAGCAGTGACTTG AGGAGGAAGGAGCTGAGAGTGGGCAGAGAATGGTGTCTGTGGAGGGCTCAGGTTCTTTGT AAGATGCTAAGATTTCAGCATAGAAGCAGGTCATGGGAAGACTGAAGTGCCTAGCGAGGA AGTTCCTGCGAGACCTGGGTGCTGGGGGGTTGGAAGAACTATGCTTGGTTTTGGGTTTCT AGTGGCTTGCCTTGGAAATGGTTTGTTTTCTGTGGCCCCAGCCCCCATTCCCCCCTGCCC CCCCAGTCCTGGAAGCTCTCAAGGCCTCCGCCTCTGCTCAGTCCTCAAGCCCTGGGCGTG GTGCCCAGAATAGGGTGCCAGAGCTGGGGAAGCCGCTGAGTCACCCTGGCTCCACCTACT GGATCTGGGCCCTGCCCCCAGAGATCAGGCACACTAGCCACAAGTGAGCCGATTGGGTTC TAGATGGGGGTCCTGGGCCCCAGGGTGTGCAGCCACTGACTTGGGGACTGCTGGTGGGGT AGGGATGAGGGAGGGAGGGGCATTGTGATGTACAGGGCTGCTCTGTGAGATCAAGGGTCT CTTAAGGGTGGGAGCTGGGGCAGGGACTACGAGAGCAGCCAGATGGGCTGAAAGTGGAAC TCAAGGGGTTTCTGGCACCTACCTACCTGCTTCCCGCTGGGGGGTGGGGAGTTGGCCCAG AGTCTTAAGATTGGGGCAGGGTGGAGAGGTGGGCTCTTCCTGCTTCCCACTCATCTTATA GCTTTCTTTCCCCAGATCCGAATTCGAGATCCAAACCAAGGAGGAAAGGATATCACAGAG GAGATCATGTCTGGGGCCCGCACTGCCTCCACACCCACCCCTCCCCAGGTACTGTCTGCT TTTCGAGTGATACCCTGGCTGGGATGTCTGTTCTGCCCTGGACTCCCAAGTCCCTGGATC TTTTCTTTCAACTAAGGGATTTATTTCCCTGCTTTCCTGGATTTCTAGGCAGAGCTAAAG TAGAAATGGCTCTAGTAAAGAAGGGTTGTGGGACTCTTCAGTGCAAACTTGGTAACCCTT TGTGTCCTGCAGACGGGAGGCGGTCTGGAGCCTCAAGCTAATGGGGAGACGCCCCAGGTT GCTGTCATTGTCCGGCCAGGTAAGTAAGCCGGTGGGACGGAGCTTTTATGGGGAAAGGGA ATGTTAACAGTTAAATGCTGAGGTGGTGGAGTGACTTGAACTGGGTACCAGAGAATGATG ACTTAGATTTCAGGTTGTGGGATTTTGAGGGTGAATTGGGTTTTGGATGAAAGTGGAAGT ATAGCTTAGGTGGGGAGAAGATGATGCGGGGTTATTAAGTTGGGAATGCCTGGGCTGGAG GATGGGGAGGAACAACAGCAGTTAAGCACTTGCCTTTAGTTGCTCATTCTTCCTTCCTAT GGTGCAGATGACCGGTCACAGGGAGCAATCATTGCTGACCGGCCAGGGCTGCCTGGCCCA GAGCATAGCCCTTCAGAATCCCAGCCTTCGTCGCCTTCTCCGACCCCATCACCATCCCCA GTCTTGGAACCGGGGTCTGAGCCTAATCTCGCAGTCCTCTCTATTCCTGGGGACACTATG ACAACTATACAAATGTCTGTAGAAGAATCAACCCCCATCTCCCGTGAAACTGGGGAGCCA TATCGCCTCTCTCCAGAACCCACTCCTCTCGCCGAACCCATACTGGAAGTAGAAGTGACA CTTAGCAAACCGGTTCCAGAATCTGAGTTTTCTTCCAGTCCTCTCCAGGCTCCCACCCCT TTGGCATCTCACACAGTGGAAATTCATGAGCCTAATGGCATGGTCCCATCTGAAGATCTG GAACCAGAGGTGGAGTCAAGCCCAGAGCTTGCTCCTCCCCCAGCTTGCCCCTCCGAATCC CCTGTGCCCATTGCTCCAACTGCCCAACCTGAGGAACTGCTCAACGGAGCCCCCTCGCCA CCAGCTGTGGACTTAAGCCCAGTCAGTGAGCCAGAGGAGCAGGCCAAGGAGGTGACAGCA TCAATGGCGCCCCCCACCATCCCCTCTGCTACTCCAGCTACGGCTCCTTCAGCTACTTCC CCAGCTCAGGAGGAGGAAATGGAAGAAGAAGAAGAAGAGGAAGAAGGAGAAGCAGGAGAA GCAGGAGAAGCTGAGAGTGAGAAAGGAGGAGAGGAACTGCTCCCCCCAGAGAGTACCCCT ATTCCAGCCAACTTGTCTCAGAATTTGGAGGCAGCAGCAGCCACTCAAGGTAAGGTGTGG TTGGACGGTAGAGGTAGGGCGGGCTAGGGGATATCGTTCCTTGCCCTCCTTGATGACCGC CCATTTTTGACATGTTTCTGGGTCCCTGCAATGGAATCTAAGAACTAGATTAAGGACTTT TAAGCCTAAAAAGGGTGATGCAAAGGGGAAATACTGTTCTTTGGCTGCTTTCTATTTCCC AGGGATTAAGGGTACTCCTTAAATTATTGGCAAAGATCCATGCTTTTATTTATTTATTTT TAATTAGTGGCAGTATCTGTGCCAAAGAGGAGACGGAAAATTAAGGAGCTAAATAAGAAG GAGGCTGTTGGAGACCTTCTGGATGCCTTCAAGGAGGTAAGGGAGCAGAAAATGGGAGGG GAGAGGGCCAAGTTGAGGTATGGAGCAGTGGTCATTCTGCAACCAAAACTGGATGTTCTG TTGTTCTAGGCGAACCCGGCAGTACCAGAGGTGGAAAATCAGCCTCCTGCAGGCAGCAAT CCAGGCCCAGAGTCTGAGGGCAGTGGTGTGCCCCCACGTCCTGAGGAAGCAGATGAGACC TGGGACTCAAAGGAAGACAAAATTCACAATGCTGAGAACATCCAGCCCGGGGAACAGAAG TATGAATATAAGTCAGGTATGCTGAAGAAAGGGTTGAGAATGGCTTGAGTTTTCTTATTA GGGCCAGAGGAGGCAGTATGATTGCTTCATTCTGTTTTCCTTGCAGATCAGTGGAAGCCT CTAAACCTAGAGGAGAAAAAACGTTACGACCGTGAGTTCCTGCTTGGTTTTCAGTTCATC TTTGCCAGTATGCAGAAGCCAGAGGGATTGCCACATATCAGTGACGTGGTGCTGGACAAG GTTAGTGGCTTCAGTTGGGGAGGGGACGATAAGTTTGTGCTGGATGGATTGGGGAGGAGC CTGAGGTCCTGAAAGAGTAGTCAACCGCTCTAGCCTGCTTCTGAGACCTTTTCCTGTCCT CTTTGCAGGCCAATAAAACACCACTGCGGCCACTGGATCCCACTAGACTACAAGGCATAA ATTGTGGCCCAGACTTCACTCCATCCTTTGCCAACCTTGGCCGGACAACCCTTAGCACCC GTGGGCCCCCAAGGGGTGGGCCAGGTGGGGAGCTGCCCCGTGGGCCGGTGAGTGGGGCTG GGTAAAGTGGCAGGTGGGCAAGGAGTGGGAGTGGATGATTCCGTGTCTCAGTGCCCGCGG GGAGGGGTTTGCCCTGGAGGCGTGTAGTAGTGGTGTCACATATTGTGCTGACTAGTTCCA TGTCCCCTCTTGTCTTCATCCCTTGCTTAGCAGGCTGGCCTGGGACCCCGGCGCTCTCAG CAGGGACCCCGAAAAGAACCACGCAAGATCATTGCCACAGTGTTAATGACCGAAGATATA AAACTGAACAAAGCAGAGAAAGCCTGGAAACCCAGCAGCAAGCGGACGGCGGCTGATAAG GATCGAGGGGAAGAAGATGCTGATGGCAGCAAAACCCAGGTACTGGCAAGTCCTGCTTTT GGTCTCTCTCCATTTCTTCTCCAGGTCTGCCATCTGTGCCCTCTTTGCTTCTTTTTGTCC TTATCACTAGCATCTGTCATGCCTAAGTCCCCACCACCCTCTCCTGTCCCTCCCAACAGC CTGTTCTGAGACCCTCACTGGAACTCTTGTCTCTTCTCCCTCCAGGACCTATTCCGCAGG GTGCGCTCCATCCTGAATAAACTGACACCCCAGATGTTCCAGCAGCTGATGAAGCAAGTG ACGCAGCTGGCCATCGACACCGAGGAACGCCTCAAAGGGGTCATTGACCTCATTTTTGAG AAGGCCATTTCAGAGCCCAACTTCTCTGTGGCCTATGCCAACATGTGCCGCTGCCTCATG GCGGTTAGTTTCCAGTGGGTTCTAAATCTAATGGTCTGGTTGCCCATTCCTATTCCCAAG ACTCCTTGAGTCCAGCTTCTTGGTTCCCCTCCAACTTGTGCCTCTTCCAGCTGGAAGGAG GCAGAGCTGGGGCCAGAGATCTTCCTGGGTCAGGTAGTTAAAGGCTCTTGGAGGGCCTTC CCTGCCCAGGACTAGTCTTGAGTGTGACATTCTCTCTGACCTACAGCTGAAAGTGCCCAC TACGGAAAAGCCAACAGTGACTGTGAACTTCCGAAAGCTGTTGTTGAATCGATGTCAGAA GGAGTTTGAGAAAGACAAAGATGATGATGAGGTTTTTGAGAAGAAGCAAAAAGAGATGGA TGAAGCTGCTACGGTGAGAGAAAACCCACTATCGATTCCACTCACCACTTACCTCCTTCC CTTACCCAGATGCTACTCAGCTGTAGAATTTGGAATGGAGGTAGTGGTGTCTTGGGGATT TCTCTGGCTCAGGACGTTTTTTTTCCTTTTTGAGACAGTCTTGCTCTGTCACCCAGGCTG GAGTGCAGTGGTGTGATCTTGGCTAGCCTCCACCTCCTGAGTTCAAGCGATTCTCCTGCC TCAGCCTCCCAAGTAGCTGGGATTACAGGCATGTGCCACCATACCTGGCTAATTTTTTTG TATTTTTAATAGAGACGGGGTTTTACCATGTTGGCCAAGCTGGTCTCAAACTCCTCCTGA CCTCAAGTGATCCGCCTGCCTCAGCCTCCCAAATTGATGGGATTACAGGCATGAGCCACT ATGCCCAGCCAGCCGGCCTCAGGACTGAGTGCTTATTGCTAGGTTTGGATATCCAGGTAG AAAAGGGTTTTAGCCGAGTGGCTGGTTATCTTTTTGACACAATCCCTGTCCTGTGAATGG CAGGCAGAGGAACGAGGACGCCTGAAGGAAGAGCTGGAAGAGGCTCGGGACATAGCCCGG CGGCGCTCTTTAGGGAATATCAAGTTTATTGGAGAGTTGTTCAAACTGAAGATGTTAACA GAGGCAATAATGCATGACTGTGTGGTCAAACTGCTTAAGAACCATGATGAAGAGTCCCTT GAGTGCCTTTGTCGTCTGCTCACCACCATTGGCAAAGACCTGGACTTTGAAAAAGCCAAG GTAGAGGTCCTTGCATCTGGAGGGGGATGGGCTGAAGCATATGTGGGGCTCACTGAGCCC ACAATGATGGGGCGGAAGGCCTGAGGAGGGGTGGGGCCTGCAGTTATAGGTGGGACATGA GAAGTTCCTGGTCTGATGCCTTTCTCCTTCCTAGCCCCGAATGGATCAGTATTTCAACCA GATGGAAAAAATCATTAAAGAAAAGAAGACGTCATCCCGCATCCGCTTTATGCTGCAGGA CGTGCTGGATCTGCGAGGGGTGTGTGTCCCCCTCCTCCCCACTGCCAGCCTGCTGCCTCC AGTTTCTGACACTGCCTTGTCTTGCCTTCCCTGACATCATCGTGACTGGCCCTCTGTCTC CACAGAGCAATTGGGTGCCACGCCGAGGGGATCAGGGTCCCAAGACCATTGACCAGATCC ATAAGGAGGCTGAGATGGAAGAACATCGAGAGCACATCAAAGTGCAGCAGCTCATGGCCA AGGGCAGTGACAAGCGTCGGGGCGGTCCTCCAGGCCCTCCCATCAGTGAGTTCCAAGCTG GGATTGAGAAGGGAGCAGTGAAGGGACCGGGAGGTTATACTTTCCTCTGATGACTTCCTG TTAGTGCCACGTGTCTGGGCCACTGAGACACCATGATGGAACTGAGGATCTGAGGAAGGG AGGCTGGGGGTGGCCCAAGGGGAAGGGGCTGCTAGGATTTATTCATTATTCCAGTATGCC CCTCTTTTTGTGTCAGGCCGTGGACTTCCCCTTGTGGATGATGGTGGCTGGAACACAGTT CCCATCAGCAAAGGTAGCCGCCCCATTGACACCTCACGACTCACCAAGATCACCAAGGTA GGGGTGTGTGTGGGAGTGGGTGATTCAGCTCAGGTTTAGATCTTAGTCCCTTCACTTTTC TAAAGTTGAGAAGGTGACAGCTGAATGTTTCCTCTTAGACTAACTGGTTGGATTGCTGGA GACAGGACTGCCAGCTGTAGAGGGAGGGTGGTACTCCCATTAGTCTGGACCAGTGTTTGG CAAACACACACACACACACACACACACACACACACGTGCCAGATCCAGCCCATTCATACA TCCCAGGACCCAGTAGTGGTTTTTACATTTTAAAGTTGCGAAAAATCAAAAAGTGAATGG TAATTTATGCTGTGGAAATTAAATAAAATGTAAATGTCAGTGTCCATGAAGTTTTATTGG AACACAGTCACAGCATGCCTTTATCATCTACAGCTGGTTTCATGCTACTGTGGCAGAATT GAGTAGTTGCAATAGAGACTGGCCCTTTATTAAAAAAGATTTTCTGACCCCTGGACTGGG CCATTCACTACCTGTTTGGTTGCATATGGTGGTGCTGGCCAAGGGACTCAGCCGGGTTGG ACCTATGATTCTACTCCCCTTTTCTTCTTCAGCCTGGCTCCATCGATTCTAACAACCAGC TCTTTGCACCTGGAGGGCGACTGAGCTGGGGCAAGGGCAGCAGCGGAGGCTCAGGAGCCA AGCCCTCAGACGCAGGTATGGAGGCAGTGTCAGGAGCTGGGTGGTTACCCGTCAGAGCTC CCTTGAGGACAGAGCCTTTTCTGTTAGGGAGGCCTTCAGTACAAGGTGGTTAGGCAATGC GGGCAATAGAGGAGGTTTGTGTTGTGGTTCCAGGGATTGAACTGCTTTACTTTTGGGACT GGGACCAAGTGTCCTAAACTGGCAAGTAGGGGATAAAATGCAGGAAAGGAGAAAAAGATT TTAATACGGATTTTCTGCATCCCCAGCATCAGAAGCTGCTCGCCCAGCTACTAGTACTTT GAATCGCTTCTCAGCCCTTCAACAAGCGGTACCCACAGAAAGCACAGATAATAGACGTGT GGTGCAGAGGTGAGGTTTCCTGGACATCTTTGTTATTCACACTGGGGGTACCGTGATTGG GTTCTGGTTGTTGCCATAGGTTGGAAATTTCTTCATACCTGTCCTGGTTGGAGCCCTTGG GTTAGATTGGGGCATACTCATTATGCTAAGAACAAGGCCCAACAGTTGCTCAGCATGTTG TGTAATTACATGAGTGCCTGGGCAGTGCAAGTGAGTGAAAATTTGTCTGTCTGTCTTCCA GGAGTAGCTTGAGCCGAGAACGAGGCGAGAAAGCTGGAGACCGAGGAGACCGCCTAGAGC GGAGTGAACGGGGAGGGGACCGTGGGGACCGGCTTGATCGTGCGCGGACACCTGCTACCA AGCGGAGCTTCAGCAAGGAAGTGGAGGAGCGGAGTAGAGAACGGCCCTCCCAGCCTGAGG GGCTGCGCAAGGCAGCTAGCCTCACGGAGGATCGGGACCGTGGGCGGGATGCCGGTGAGA GTCTGGGAGAGGAATGGAGGGAAAGGCATTGGCTGCCTTGGGACTAGCTGGTCCCCAGCT TTTTGAGAGCTCCAAATCTTGTTTGCTGGGAAGACTGAAAAGTCCCTCTAATCTGTGTTC TCTTCCCACAGTGAAGCGAGAAGCTGCCCTACCCCCAGTGAGCCCCCTGAAGGCGGCTCT CTCTGAGGAGGAGTTAGAGAAGAAATCCAAGGCTATCATTGAGGAATATCTCCATCTCAA TGACATGAAAGTAGGCAGTGGGAGCGGCGTGTGATTGAGGAGTGGGCAGGGAGGGATCAT GCTGGCAGGCATAGGGGTCCGGGGTCTGGGTCAGACAGTGACTGGTCTCTTCCTGCTGTG CCCTGCACCCCTCAGGAGGCAGTCCAGTGCGTGCAGGAGCTGGCCTCACCCTCCTTGCTC TTCATCTTTGTACGGCATGGTGTCGAGTCTACGCTGGAGCGCAGTGCCATTGCTCGTGAG CATATGGGGCAGCTGCTGCACCAGCTGCTCTGTGCTGGGCATCTGTCTACTGCTCAGTAC TACCAAGGGTATGACCAGCTTCTCTGGGCCTCCCACTTATACAGACCCACAATTTTCTAT CTCCTTTTTGGGACCCTTGGAACCTTGCATAAGAGTGTAGGTTCCCTGGCCGGGTGTGGT GGCTTATGCCTGTAATCCCTGCACTTTGGGAGGCCAAGGTGGGTTGGATTCCTTAGAGGA TCACGTGAGGTTGGGAGTTCTAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACT AATAATACAAAAATTAGCCAGGCGTGGTGGCACAGTAATCCCAGCTACTCGGAGGCTGAG GCAGGAGAACTGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCGTGCCATTG CACTCCAGCCTGGGTGACAAAAGCAAAACTGTCTCAAAAAAAAAACCAAAAAACAGTATG GGTTCCTTGACCATCCTGGTCAGCATAACTTTAGGGGGTTAAGCGGGGTGAAAACCATCT AAGGACACAGAGGTGGCCTTAGCTTGAAATAATTGTCCCCATGTCTAGAAAATGTTCCTG GGGGTTCCATAGTTGATGCCCTAGCCATGCCACGTTGCCCCAGAAGGAGAGTGGGGACCT GGCCTAGAATGTCTTGACTTTGAATTCCCTTGGCAGGTTGTATGAAATCTTGGAATTGGC TGAGGACATGGAAATTGACATCCCCCACGTGTGGCTCTACCTAGCGGAACTGGTAACACC CATTCTGCAGGAAGGTGGGGTGCCCATGGGGGAGCTGTTCAGGTAAGTCCCCCTGGGTGG AATTCAGGGGAGGTAAAGACCAGAGGAAAGGTGGTAGGGAAATGGCTGGGTTGGATACCC TGGTTTGGAGGGAGATGGAGTAGTGGTGAGAGAACTGTGGAGGCTGTCAGCATTAGGTTT TTCTCTTCTTGTAGGGAGATTACAAAGCCTCTGAGACCGTTGGGCAAAGCTGCTTCCCTG TTGCTGGAGATCCTGGGCCTCCTGTGCAAAAGCATGGTGAGTGAGGGCCAGGAGTCCAGA GATGCCTCCCACGGTGTGGTTTTGGCTGTTTGCTGTGGCCCTGAAGCTTCATGGTCCATT GGTGGAGTGGAGTGATGGTGATGACAGGATTGTGTTGGTACCTGGGAGAGGAAATACTGA GGTGGGCCATCTCCCGCACACCAGTTCCTATCATGAGTTCTGGCCAAGACTGGAGGAGAA TGGCAGTCTAAGACCCTAGGCCTGTGATTGATGCATTTATTTATTCATTCATTGAACTAG GGTTTTGTTGATGATCATTTATCATATACTAAGCACTAGGGACACAGCAATGAATAAAAC ACAAGAAACAAGTTGGTAGAGAAAAAGGAAGAAATGGGCCGGGCGCAGTGGCTCACGCCT GTAATCCCAGCACTTTGAGAGGCCGACGTGGGTGGATCACGAGGTCAGGAGTTCAAGACC AGCTTGGCCAATATGGTGAAACCCCATCTCTACTAAAAACACAAAAATTAGCCGTGTTGT GGCAGGTGCCTGTAATTCCACCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGACCCGG GAGGCGGAGGTAGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGAAACAGAGC AAGACTCTGTCTCCAAAAAAGAAAAAAGAAATGACAGCTTGATAAAAACAACAGTAAAGC GTGACATAAAACAGTTGAAATAGAGTGGAGTATCTTAAGTACTGTGGGGTTGCAAAGGAA TATTTGACAATATTTGTGACAGGAGGCTTTCAGGGTGCTGAAGCGGCTTTGTGAAAGTTA ATTGGTAACTAGCGAATATAAAGGTAAAGAGATGGGGAAAGGTAAGTTGAATGTGGTACT TAGTGGAAGTGAGAAGTTGGGGTGAGTGTGTGCAGTTTCAAGGGTTCAGCCATCTGGAAC CTGGAGGAATCACACTTGGGATTTAAAGGAATTGTTATGTCAACATCATTTAATTCTTTT AAATAGACGTGTACCAGGACAAGTTGTTTTTTAACAACAAATAAGCATATTGAACTATTT GTGTATTTCATCAACTCCAAGGTGCCATAGATTATAAGACATTCTTTATGCGCTGTTAAG AAAGAAAAGACTGGGCCGGGCGTGGTAATCCCAGCACTTTGGGAGGCAGAGGTGGGTGGA TCACGTGAGGTCAGGAGTTGGAAACCAGCCTGGCCAACATGATGAAACCCTGTATCTACT AAAAATACAAAAAAATTAGCTGGACATGGTGGTGCGCACCTGTAGTCCCAGCTACTTGGG AGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGGGGAGGTTGCAGTAAGCCAAGATTG TGCCACTGCACTCCAGCCTGGGCGACAGAGCAAGACTCTGTCTCAAAATAAAAAAAGATA TATATCGGCTGTAAGACAACTTTTAGTTAAAATGTGAAAAAATGGGCATGTTTTAAAATC TGTGAACTGCAATAATCTTGCTAAGAGCCAGTGCCATTAGTCTGTTATAAAGAAAAGAGT GATGTCTTCATAGTCTATTGCCCCTTACAGAAAATGCACTCAGACTGCTGGTTTTATGAG GATTTTTTATTTGTGTTAGGGATGGGGTATATTTGTGTCTTAAGATTTTCTGGGTTTAGG AAACAAGCATACTTGTTAGAAGTTGTCCCTTCCTAGAGGCCCTTACATCATTTTTCCTAC CCTAGTGTCATAGCACTTTGGTGGACAAGTTCTCTTTTATTTTATTTTATTATTATTATT TTTTTGAGACAGAGTCTCGCTGTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCT CATTGCAACCCTCGCCTTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGG GATTACAGGCACCCACCACCACGCCTGGCTAATTTTTGTATTTTCTGTAGAGACGGGGTT TCACCATGTTGGTCAGGCTGGTCTCCGACTCCTGACCTCAGGTGATCCGCCCACCTCGAC CTTTCAGAGTGCTAGGATTACAGGCGTGAGCCACCGCCCGCTCCTGGGACGAGTTCTTAT TTATTTGGGTGGTTATTTGACTGACATCTGTGCCCTGCACCAGACCGTAGGAATGGAAGG GCTTTGCCTATTAGTATTTCTATAGCATCCTTAATGCCTAGCAAGTACCTAGTAGGCTTT CAGTAAATATTTGTTGGATTAATGTGGTAGAGCTGTTGGGTCCTTGGAGAGAGAGAGCTT TGGTAAGCTGGGTTGGTCTTGTGTTTTCCAGGGTCCTAAAAAGGTGGGGACGCTGTGGCG AGAAGCCGGGCTTAGCTGGAAGGAATTTCTACCTGAAGGCCAGGACATTGGTGCATTCGT CGCTGAACAGGTTTGGGGATGGAGTTGGGTTAATTCTAGCATTTGAGGCTGGCCAGTCTT CTTTCTTGTCTCCTGTTGGCAACCTTACCTCTTAACTGCGGGCCTTTTCCATTGCAGAAG GTGGAGTATACCCTGGGAGAGGAGTCGGAAGCCCCTGGCCAGAGGGCACTCCCCTCCGAG GAGCTGAACAGGCAGCTGGAGAAGCTGCTGAAGGAGGGCAGCAGTAACCAGCGGGTGTTC GACTGGATAGAGGTAGGTTTCTCCTGGATATCGATAAAGGAAAGGTAGTTCTTAGGGTGG GGGTGGGGGCAGCAAGAATGAAGACTGAAGGGCCCAATTCAGAATCTGGGGATCATTTGT TTCTCCCATACAGGCCAACCTGAGTGAGCAGCAGATAGTATCCAACACGTTAGTTCGAGC CCTCATGACGGCTGTCTGCTATTCTGCAATTATTTGTAAGAGGAACCAGGGAGATGGAGG GGCAAGGGTGGGCCTGACAGACAAGTGGAGGGAGGTGGGTGTCAGCCTTGGCCTCCCAGT TCTGAACCGGGGTAAGGGTATATTGCTCCACTCATCCCTGTCTTCTTGTAGTTGAGACTC CCCTCCGAGTGGACGTTGCAGTGCTGAAAGCGCGAGCGAAGCTGCTGCAGAAATACCTGT GTGACGAGCAGAAGGAGCTACAGGCGCTCTACGCCCTCCAGGCCCTTGTAGTGACCTTAG AACAGCCTCCCAGTAAGAGCCAGGCCATGGGGACAGGGGTGGGGTGGAGGGACTGCCAGA TAGCAGGGCATGAGACCCTTCATGGAAGGGTCTTAATCCAAGAAAGGTAGGTAGTCATTA GAGAGCAAAATGCCCTCTGGGTTTCATTCTTTCCTTTTACGTTTGTGTTGTGTTGTTCCT ACAAGTGGAAGGAGTTAGACACAGCCTTGAAGGGTAATTGCCTGTTTTGTGCCTAGCCAT GTGTTTGATGCCAACAGTGCAGAGGTGATAAATGATAGGATCTTCCCAGTACCGTGTGCC CCCACGGCGTGGCACAGGGCTGAAATGCTTTGCTTACCTTGCCTCATGTAGTCCTCACAA ATGTTGTTTAGGGTGGATGGTATTACCCCTATTTTCCACATGAGGAGACTGAGGTCTCAG TGAACATGTCTCAGGTTATGCATTCAGAACATAGGTATGTGTCAGGGCATTGGCATGCTC ACAGAGAGGAAGCCGAGCAATTTCCTGTGCTGGCCTGGAGTTAGTACTGGCGTGAGCAAT GAGCCTGGGAAGACGGGTGCTCTCGGAGGGAGGACACCTGGTCTGAGGGGTAATGAGTGG TAATTCACTCCACAACAACTGGGAAGGGGAGGGGGAGAATGTTTGAAGCGAAGGCACTAT GTGTGTTCTTTCTACCTATGGTAGGAAGAACTTGACACAGGGAAAAGAACTATTAAAGAA AGGCCAGTGTGGGAGAGCACAGCAACCAGTCCTAAGTGAGGCAAGATGGGGCCGAAGAGA GGGATGTGGGCCTGACCACACAGGGCCGGGTGTAAGCCATGGCCAGAGTCTGGGGCTTTA GCCTGGGGGCAAGAAAACGCCTTTGTGGGATTTTAAGCAAGGAATAAAGGAATTTGATTT TAGTTTTTAGATCATCTTGGCAATAGAGGGAAGAGTGGTTTGGAATGGGGTGAGAGTGGA TGTGGCAGTGTTAGCACCAGTGGCTCAGCCTTGCTGGTGATGGTGGAGAGGAGTAGGCAG ATCAAGAGATACTTAGGAAATGGAGTTGGCAGCTTTTGGTTACACTGGTCTGGGGAGGGG GCCGTGAGAGATTAGAAGTCATGGATGACTCCCAGGATGGTTTTTAAATCACAGTGGGCT TAGAGGCCATAGTGTGATGTCATTTGCTGGGGTAGGCAACGGTGGATCAAGTTGAGTTGT GGTCCTTGAGTAAGGGAATCGAGATGTCAGCTCAATAGCTGGGGTATCTGGGTCCTTTTG GAAAAGAAGAGATCAGGGCAGGAGGCAGCTTTGTGAAATGCCGGCACAGGGTAACTCATG TGCAAGTCATAAGAGGATACGGGCTTGCCTGAGGGAGAGTGATAAGGGCCTGAGATACAG CCCCAAGGAGGTAGAGCGGACATACTGGTAGGGACCAAAGGAGGACAGGCCCCTCTGAAC CAAGGACAGAGAAATTTGAGGAGAGGGATGTGGTTGATAATGCCAGATGCTGCTGTGAGC GTTTGTAGGAGTGGGCCTGAAAATGCAGGATGTTTGGAATATAAAAACATAGAGGCCACC CTGGCAAAAACAGTATTTAGTGGGGCAGGGGACAGATTCTGGATTGGAAAGGACTGAGAA ATACTTAAGTGAGACAGAAAGAAGGGAAAACATCAAGTGTAGACAAAATATTTTATTAGC TGTAAGATAGTGGTTGAAAACAGGGCTTTTTGTTTTTAGGTTAGAGAAACTTGGGCTTGA AAATACAGGGCAGAGTGCATAATCGATTGGATGGGGTCCCTGGGTGGGTATGTGTGGGAT TTGGAGTGTAGGTACGGGTTAAGTGAAGGTTCTGCCCTGCTATGGCCCATTGCTATGGGG TGGGGGTAGCAGGTGACTGTGCCCCTAGGCAGTTTGTGACTTTGAGGCTGGGCATGCCCT GCAGAACATCCTGGCTGGCAGCATCTCATAGATGGCTTAGAAGTGTAAGGTTTGGTTTGG AAAGACTGGTGGTGCCTTGTGGGCACTGGGGTCGGTTGTGTTTCAGGGGTTATAGGACAC GTTGCTTGGGAAGGCTACCCAGCAGCTAGGGGTTGAGGAGAAAGAGGGCCCGAACAGGTG ATGCTTGAGTTGAGTCCTGAAGGAACAAGACACGAGGAAGTTTCCGGCAAAGGATATAGC ATCCACAAAAGTGTCAAGGCCAGAGAAGGTGTGTATGTACAGGAAATGTGTGGGGAAGGA AGGGAAATTGAGATCAGGAGTTGTCAGGATCTGTTTGGGGGGCAGTGAATGTTCAGGTTA CATGTAGGATATATATAGGACTTTATGTATGATATATATAGGACTTTTAGCGATTTCCTG AATTCAGGAGTACCAATTCTGAATATAGTTTTCTCCATTAAATACATCATGGGCAGAGAG GTTTCAGGCTGCCAAGGTGAGGCCAAGCAAGTTTGTAAGGTTTTTCTGATGGCCAAGTGA CTCATTGCTGTGCAGCAGTCTCAGATCATGAGATTAGCATCCTGTCAGAGGCCTAGTCAC TCTGGAATGGCCACAAATGTCAGGCTGGTGCATCAGGGCCTTGTTTGAACAGTGGAACTT GGGAGGGTTCCCTGGGGTGGGCTGGGGTGGCGGTGGCCAGTCACCTCTAACTGCTGTCCC GCCTGCTTGCAGACCTGCTGCGGATGTTCTTTGACGCACTGTATGACGAGGACGTGGTGA AGGAGGATGCCTTCTACAGTTGGGAGAGTAGCAAGGACCCCGCTGAGCAGCAGGGCAAGG GTGTGGCCCTTAAATCTGTCACAGCCTTCTTCAAGTGGCTCCGTGAAGCAGAGGAGGAGT CTGACCACAACTGAGGGCTGGTGGGGCCGGGGACCTGGAGCCCCATGGACACACAGATGG CCCGGCTAGCCGCCTGGACTGCAGGGGGGCGGCAGCAGCGGCGGTGGCAGTGGGTGCCTG TAGTGTGATGTGTCTGAACTAATAAAGTGGCTGAAGAGGCAGGATGGCTTGGGGCTGCCT GGGCCCCCCTCCAGGATGCCGCCAGGTGTCCCTCTCCTCCCCCTGGGGCACAGAGATATA TTATATATAAAGTCTTGAAATTTGGTGTGTCTTGGGGTGGGGAGGGGCACCAACGCCTGC CCCTGGGGTCCTTTTTTTTATTTTCTGAAAATCACTCTCGGGACTGCCGTCCTCGCTGCT GGGGGCATATGCCCCAGCCCCTGTACCACCCCTGCTGTTGCCTGGGCAGGGGGAAGGGGG GGCACGGTGCCTGTAATTATTAAACATGAATTCAATTAAGCTCA OMIM ID 600495