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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DAND5 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 199699 Official gene symbol DAND5 Full name DAN domain family, member 5 Aliases ,CER2,CERL2,CKTSF1B3,COCO,CRL2,DANTE,GREM3,MGC126849,SP1, Gene summary This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq] Location Chromosome: 19   Locus: 19p13.2 Gene position 13080432 - 13085567  Map Viewer Gene orientation plus Gene size 5136 bp Gene sequence >DAND5:4343234..4348369:Length=5136 AGTCCGGACAGACAGACAGGCAGACAGACGCACGGACAAGCAGATGCTCCTTGGCCAGCT ATCCACTCTTCTGTGCCTGCTTAGCGGGGCCCTGCCTACAGGCTCAGGGAGGCCTGAACC CCAGTCTCCTCGACCTCAGTCCTGGGCTGCAGCCAATCAGACCTGGGCTCTGGGCCCAGG GGCCCTGCCCCCACTGGTGCCAGCTTCTGCCCTTGGGAGCTGGAAGGCCTTCTTGGGCCT GCAGAAAGCCAGGCAGCTGGGGATGGGCAGGCTGCAGCGTGGGCAAGACGAGGTGGCTGC TGTGACTCTGCCGCTGAACCCTCAGGAAGTGATCCAGGGGATGTGTAAGGCTGTGCCCTT CGTTCAGGTGAGTGGGTGGGTGTGGGGAGGAGAGGGCTGGGTCTCACCATTGGCAGAAGG CACAGGCTGTGGCCCAAGAAAGATTTGGGTTCAAGTCCTGTATCCTCCACCTGAATGTCT CGGTGCCTCAGTTTCCTCCCTTGTAAAATGCGACCCAAGCCTCCTCTATCCTGGTCTCCT TGATTCCACTATCATGCCCCTCTCCACCCCCCAGTCTATTTTTCCACTCAGCAGCCAGAG GGTGCCTGTGAACACCAGAGTCAGATCTGGTTCCCCCTCCCCCTAGAACCTTGCATGGCT CCCACTTTACTCAGAACAAAAGCCCAAGTCCTCTTCACAGCCCACAAATTTCTGTACTCT CTGATCCTGTTACCTCCCTGATTTCACCTCCTCCCACTCTCCCCCTCAGTTACTTTGCTT CTACACATCAGCCTCCTTTTCCTCAGACACCAACTTTCTTTCTGTTTTTTTAGACACGGG AGTCTCGCTATGTTGCCCAAGCTAGTCTTGAGCTTCTGGCCTCAAGCAATCCTCCCACCT CAGCCTCCTGAGTTCTAGGTGTGAGCCCGTCTCTTGCTTGATATACCAACTTTCTTTCTT TTCTTTCTTTCTTTCTTTTTCTCTTTCTTTCTTTCTTTTCTTTCTTTGTTTTTCTTTTTT TCTCTTTCTTTCTTTCTTTCTTTCCTTTCTTTCTTTCTTTTCTCTCTCTCTCTTTCTTTT TTTGAGACAGTCTCACTCTGTCACCCAGACTAGAGGGCAGCAGTACAATCTCGGCTCACT GCAACCTCCACTTCCTGGGCTCAAGTGATTCTCGTGCCTCAGCCTCCCAAGTAATTGAGA TTACAGATGTGCACTACCATGTCCGGCTAAATTTTGTACTTTTTGTAGAGACGTGGTTTG GCCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGACCCGCCTGCCTCGGCCC CCCAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCCAGGCCAATGAGAAGTCTCTTATG AGGAAGATGGCTCAGGATTTAAGCAGAGAAGGACCAGGATTTGGGGGAGAGATGATAGAT CCACTTGGAGGGGATCATAGGAGGAACTAACATGCATTGAGCACCTACTTTGTGCCAGGC AGTGGGCTAAGGGCTTTCTGTTGGATGCTTCCGGGCTCCTGTGATACTGCTGTCCCTTCC CCCTAGGGTGCTAGTTGGCTTCCTACTGGTACCATCATCAGGCCATCTTATCATCATATC CTGCTTGGCTTTTCTTTACTTTTCTTTTCTTATTATTTATTTTATTTTATTTTATTTTTG AGATAGAGTCTCGCTCTGCTGCCCAGGCTGCAGTGCAATGGCGCGATCTCAGCTCACTGC AACCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTTAGCCTTCCGAGTAGCTGGTTTT ACAAGCACACGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGCTTTCAC CATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCATGATCCACCTGCCTCGGCCTCCCC AAGTGCTGAGATTACAGGCATGAGCCACTGCACCCGGCCTTCTTTACTTTTCTTTTCAGG TTTTTGTTTTTTGAGACAGAGTCTCACTCTGTCGCCTAGGCTGGAGTACAGTGGTGCAAT CTCGGCTCACTGCACCTCCATCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGA GTAGCTGGGACCACGGGCGCCTGCCACCATGCTCAGCTAATTTCTGTATTTTTAGTAGAG GCGGGGTTTCACTATGTTGGCCAGGATGGTCTTGAATTCCTGACCTCAAATGATCCACCC ACCTCAGCCTCCCAAAGTGCCAGGATTACAGGCGTGAGCCACCACACCCGGCCTTTTCAT GTTTTTTGTTAGAGACAGGGTCTTACTCTGTCACCCAGGCTGGAGTACAGTGGTGCGATC ATAGCTCACTGCAGATTTGAATTCCTAGGATCAAGCAATCCTCCTGCCTCAGCCTTCTGA GTAGCTAGGCCTACAGACGCACAGCATTAGCCCAGCTAATATTTTTTTTTTTTTTTTTTG AGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCGGTGGTGGGATCTCGGCTCACTGC AAGCTCCGCCTCCTGGGTTCACGCCACTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACC ACAGGCGCCCACCACCACGCCTGGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTC ACCATATTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCTGCCTGCGTTGGCCTCC CAAAGTGCTGGGATTATAGGCATGAGCCACCGTGCCTGGCTAGCTCAGCTAATTTTTTTT TTTTAATTTCTTTGTAGAGACAGGGTCTTACTATATTGCCCAGGCTGGTCTCAAGCCACC ACATCCCGCCCTTGGCTTTTAACTCCGAGGTAACCAATTCCCTGAATTAGTCCTCTTTGT TGAAAGGCCTAAAGTGATTTCTTCTTTTTCTCATTTAATTAATTTATTTGTTTATTTATT TCGGAGACAGAGTCTCGCTCTGTTACCCAGGCTAGAGTGCAATCATGATCTCAACTTGCT GCAACCTTCACCTCCCAGGTTCAAGCAATTCTTCCACCTCAGCCTCCCATGTAACTGGGA TTACAGGTGTAGGTGCCCATGCCCGGCTAAGTTTTGTATTTTCAGTAGAGATGGGGTTTC GCCATATTGGCCAAGCTGGTCTCAAACTCCTGGCCTGAAGTGATCCGCCCACCTCAGCCT CCCAAAATGCTGGGATTACAGGCTTGAGCCACCACACCTGGCTGTCTTTGTTGAATTTCT TTTCTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCCCCAGGCTGGAGTGC AGTGGCGCTATCTCGGCTCACTACAAGCTCCGCCTCCTGGGTTCACACCATTCTTCTGCC TCAGTCTCCCGAGTAGCTGGGACTACAGGCGCCCACCACCACGCCCGGCTCATTTTTTGT ATTTTTAGTAGAGACGGGGTTTCACCGTGTTGGCCAGGATGGTCTCGATCTGCTGACCTC GTGATCCGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCC GGCCCTTGTTGAATTTCAATGATTTTCCAGGTGAGGAAACAAAAGCTCAGAGAGGCTAAG TAATTTGCCCCATGTCTCAGCCAAGAGACAGCAGAGTCAGGATTTGAACCCAGGCAGCCT GGCTGCAGCATCCATGCCTGTCAAGGTGGGGTGGAAGTGGACAGGTGATTATCCTCGCCA CTCTGGCCCCAAACTCCGCCACCCTGACCGTCTCCATGCCTCCGGCCCCAGGTGTTCTCC CGGCCCGGCTGCTCAGCCATACGCCTCCGAAATCATCTGTGCTTTGGTCATTGCTCCTCT CTCTACATCCCTGGCTCGGACCCCACCCCACTAGTCCTGTGCAACAGCTGTATGCCTGCT CGCAAGCGTTGGGCACCCGTGGTCCTGTGGTGTCTCACTGGCAGCTCAGCCTCCCGTCGA CGGGTGAAGATATCCACCATGCTGATCGAGGGGTGTCACTGCAGCCCAAAAGCATGAACT GAGCATCGTGGATGGGTGCACGGAGACACGCACCTTGGAGAAATGAGGGGAGATGGACCA AGAAAGACGTGGACCTGGATGATGTACTCTGGGTCAAGAGACCAGGGATGCAGGGTTAGG CAGACAGGTCCCCAGAGTCCTCACCCTGCTCCCCAGACAGTAGACACAGTGCCCGTCCTG GAGTTGCACCACTGATAGTCACAGCACACAATGATTGACAACTCACTTTTTTTTTTTTTT TTTGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCAGCTCA CTGCAAGCTCCACCTCCCGGGTTTATGCCATTCTCCTGTCTCAGCCTCCCGAGTAGCTGG GACTACAGGCACCCGCCAACACGCCCGGCTAATTTTTTGTATTTTTAGTAAAGACAGGGT TTCACCGTGTTAGCCAGGATGGTCTCTATCTCCTGACCTCGTGATCTGCCTGCCTTGGCC TTATTATTTTTTTTTTTTAAGGACAGAGTCTCTCTCTGTCACCCAGGCTGGAGTGCAATG GCGCGATCTTGGCTCACTGTAACTTCCACTTGCCAGGCTCAAGCAGTTCTCCTGCCTCAG CCTCCTGAGTAGCTGGGACTACAGGCACCCGCCACCATGCCCAGCTAATTTTTGTATTTT TAGTAGAGACAGAGTTTCACCATATTAGCCTGGCTGGTCTCAAACTCCTGGCCTCAGGTG ATCTGCCCACCTCGGCCTCCCAAAGTGCTGGGATCAAATCCACTGTTAATCATTAGGCTG AACTGTCTCTTATAGAATGAGGTCAAAGACACTCCCAGTTGCAGGGAGGGTAGATGGCCC CACCCAGACCGAGAGACACAGTGATGACCTCAGCCTAGGGACACCAAAAAAGAAAAAAAA AAAAACCCAAACCAAAAACGCAAACCAAAGCAGGCAGGCAGACAGCTGCTGGGGGAAATC CTGGGGTCCTTGAGACAGAGGCAGGACCCTCGTGTTCCCAGCTGCCTCTTGCCTTGATAG TGGTGCTGTGTCCCTCTCAGACCCCCCACCTGAGTCTCCACAGAGCCCCACGCCTGGCAT GGCATTCCACAGAAACCATAAAGGTTGGCTGAGTCC OMIM ID 609068