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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CTTN (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2017
Official gene symbolCTTN
Full namecortactin
Aliases,EMS1,FLJ34459,
Gene summaryThis gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q13
Gene position70244612 - 70282690  Map Viewer
Gene orientationplus
Gene size38079 bp
Gene sequence
OMIM ID164765