Entrez gene ID | | 2033 |
Official gene symbol | | EP300 |
Full name | | E1A binding protein p300 |
Aliases | | ,KAT3B,p300, |
Gene summary | | This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq] |
Location | | Chromosome: 22 Locus: 22q13.2 |
Gene position | | 41488614 - 41576081 Map Viewer |
Gene orientation | | plus |
Gene size | | 87468 bp |
Gene sequence |
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OMIM ID | | 602700 |
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