Entrez gene ID | | 2107 |
Official gene symbol | | ETF1 |
Full name | | eukaryotic translation termination factor 1 |
Aliases | | ,D5S1995,ERF,ERF1,MGC111066,RF1,SUP45L1,TB3-1, |
Gene summary | | Termination of protein biosynthesis and release of the nascent polypeptide chain are signaled by the presence of an in-frame stop codon at the aminoacyl site of the ribosome. The process of translation termination is universal and is mediated by protein release factors (RFs) and GTP. A class 1 RF recognizes the stop codon and promotes the hydrolysis of the ester bond linking the polypeptide chain with the peptidyl site tRNA, a reaction catalyzed at the peptidyl transferase center of the ribosome. Class 2 RFs, which are not codon specific and do not recognize codons, stimulate class 1 RF activity and confer GTP dependency upon the process. In prokaryotes, both class 1 RFs, RF1 and RF2, recognize UAA; however, UAG and UGA are decoded specifically by RF1 and RF2, respectively. In eukaryotes, eRF1, or ETF1, the functional counterpart of RF1 and RF2, functions as an omnipotent RF, decoding all 3 stop codons (Frolova et al., 1994 [PubMed 7990965]).[supplied by OMIM] |
Location | | Chromosome: 5 Locus: 5q31.1 |
Gene position | | 137878932 - 137841784 Map Viewer |
Gene orientation | | minus |
Gene size | | 37149 bp |
Gene sequence |
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OMIM ID | | 600285 |
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