Entrez gene ID | | 211 |
Official gene symbol | | ALAS1 |
Full name | | aminolevulinate, delta-, synthase 1 |
Aliases | | ,ALAS,ALAS3,ALASH,MIG4, |
Gene summary | | Delta-aminolevulinate synthase (ALAS; EC 2.3.1.37) catalyzes the condensation of glycine with succinyl-CoA to form delta-aminolevulinic acid. This nuclear-encoded mitochondrial enzyme is the first and rate-limiting enzyme in the mammalian heme biosynthetic pathway. There are 2 tissue-specific isozymes: a housekeeping enzyme encoded by the ALAS1 gene and an erythroid tissue-specific enzyme encoded by ALAS2 (MIM 301300).[supplied by OMIM] |
Location | | Chromosome: 3 Locus: 3p21.1 |
Gene position | | 52232116 - 52248343 Map Viewer |
Gene orientation | | plus |
Gene size | | 16228 bp |
Gene sequence |
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OMIM ID | | 125290 |
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