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Gene information for F11 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2160
Official gene symbolF11
Full namecoagulation factor XI
Aliases,FXI,MGC141891,
Gene summaryThis gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q35
Gene position187187118 - 187210835  Map Viewer
Gene orientationplus
Gene size23718 bp
Gene sequence
OMIM ID264900