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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTK2B (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2185
Official gene symbolPTK2B
Full namePTK2B protein tyrosine kinase 2 beta
Aliases,CADTK,CAKB,FADK2,FAK2,PKB,PTK,PYK2,RAFTK,
Gene summaryThis gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 8   Locus: 8p21.1
Gene position27168999 - 27316903  Map Viewer
Gene orientationplus
Gene size147905 bp
Gene sequence
OMIM ID601212