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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FHIT (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2272
Official gene symbolFHIT
Full namefragile histidine triad gene
Aliases,AP3Aase,FRA3B,
Gene summaryThis gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
LocationChromosome: 3   Locus: 3p14.2
Gene position61237133 - 59735036  Map Viewer
Gene orientationminus
Gene size1502098 bp
Gene sequence
OMIM ID601153