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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CARD8 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID22900
Official gene symbolCARD8
Full namecaspase recruitment domain family, member 8
Aliases,CARDINAL,DACAR,DKFZp779L0366,Dakar,FLJ18119,FLJ18121,KIAA0955,MGC57162,NDPP,NDPP1,TUCAN,
Gene summaryThe protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq]
LocationChromosome: 19   Locus: 19q13.33
Gene position48759203 - 48711343  Map Viewer
Gene orientationminus
Gene size47861 bp
Gene sequence
OMIM ID609051