Entrez gene ID | | 22900 |
Official gene symbol | | CARD8 |
Full name | | caspase recruitment domain family, member 8 |
Aliases | | ,CARDINAL,DACAR,DKFZp779L0366,Dakar,FLJ18119,FLJ18121,KIAA0955,MGC57162,NDPP,NDPP1,TUCAN, |
Gene summary | | The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq] |
Location | | Chromosome: 19 Locus: 19q13.33 |
Gene position | | 48759203 - 48711343 Map Viewer |
Gene orientation | | minus |
Gene size | | 47861 bp |
Gene sequence |
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OMIM ID | | 609051 |
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