Entrez gene ID | | 22901 |
Official gene symbol | | ARSG |
Full name | | arylsulfatase G |
Aliases | | ,KIAA1001, |
Gene summary | | Sulfatases, such as ARSG, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This gene, a novel arylsulfatase, has activity toward pseudosubstrates including p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. Activity is competitively inhibited by phosphate. The unprocessed protein is active as a 63-kDa monomer and demonstrates an acidic pH optimum as typically seen for lysosomal sulfatases. The protein accumulates within lysosomes and is also a glycoprotein that binds specifically to mannose 6-phosphate receptors. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17q24.2 |
Gene position | | 66255323 - 66417000 Map Viewer |
Gene orientation | | plus |
Gene size | | 161678 bp |
Gene sequence |
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OMIM ID | | 610008 |
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