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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for KLRK1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID22914
Official gene symbolKLRK1
Full namekiller cell lectin-like receptor subfamily K, member 1
Aliases,CD314,D12S2489E,FLJ17759,FLJ75772,KLR,NKG2-D,NKG2D,
Gene summaryNatural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. [provided by RefSeq]
LocationChromosome: 12   Locus: 12p13.2-p12.3
Gene position10542640 - 10524952  Map Viewer
Gene orientationminus
Gene size17689 bp
Gene sequence
OMIM ID611817