Entrez gene ID | | 22914 |
Official gene symbol | | KLRK1 |
Full name | | killer cell lectin-like receptor subfamily K, member 1 |
Aliases | | ,CD314,D12S2489E,FLJ17759,FLJ75772,KLR,NKG2-D,NKG2D, |
Gene summary | | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12p13.2-p12.3 |
Gene position | | 10542640 - 10524952 Map Viewer |
Gene orientation | | minus |
Gene size | | 17689 bp |
Gene sequence |
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OMIM ID | | 611817 |
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