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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for KIFAP3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID22920
Official gene symbolKIFAP3
Full namekinesin-associated protein 3
Aliases,FLJ22818,KAP3,SMAP,Smg-GDS,dJ190I16.1,
Gene summaryThe small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q24.2
Gene position170043879 - 169890470  Map Viewer
Gene orientationminus
Gene size153410 bp
Gene sequence
OMIM ID601836