Entrez gene ID | | 22920 |
Official gene symbol | | KIFAP3 |
Full name | | kinesin-associated protein 3 |
Aliases | | ,FLJ22818,KAP3,SMAP,Smg-GDS,dJ190I16.1, |
Gene summary | | The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q24.2 |
Gene position | | 170043879 - 169890470 Map Viewer |
Gene orientation | | minus |
Gene size | | 153410 bp |
Gene sequence |
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OMIM ID | | 601836 |
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