Entrez gene ID | | 23092 |
Official gene symbol | | ARHGAP26 |
Full name | | Rho GTPase activating protein 26 |
Aliases | | ,FLJ42530,GRAF,KIAA0621,OPHN1L,OPHN1L1, |
Gene summary | | Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q31 |
Gene position | | 142150292 - 142608572 Map Viewer |
Gene orientation | | plus |
Gene size | | 458281 bp |
Gene sequence |
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OMIM ID | | 605370 |