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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TPSD1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 23430 Official gene symbol TPSD1 Full name tryptase delta 1 Aliases ,MCP7-LIKE,MCP7L1,MGC95428,MMCP-7L, Gene summary Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein. [provided by RefSeq] Location Chromosome: 16   Locus: 16p13.3 Gene position 1306273 - 1308494  Map Viewer Gene orientation plus Gene size 2222 bp Gene sequence >TPSD1:1246273..1248494:Length=2222 AGGCCCACGATGCTCCTCCTTGCTCCCCAGATGCTGAGCCTGCTGCTGCTGGCGCTGCCC GTCCTGGCGAGCCCGGCCTACGTGGCCCCTGGTGAGTCCCAGCCGGGGTCCACCCTGCCC CTCACCACATTCCACAGATCAGGGCCTGGGTGGGTTCTGGGGAGGCCGGGCTGGCCCCCA CACAGGGAAGGGCTGGTCCCAGGCGTGGGGCGGCTTCTTGGTCCTGACCTGGCACCTGCC CCAGCCCCAGGCCAGGCCCTGCAGCAAACGGGCATTGTTGGGGGGCAGGAGGCCCCCAGG AGCAAGTGGCCCTGGCAGGTGAGCCTGAGAGTCCGCGGCCCATACTGGATGCACTTCTGC GGGGGCTCCCTCATCCACCCCCAGTGGGTGCTAACCGCGGCGCACTGCGTGGAACCGTGA GTCTCCTGGGGCCTGGAGGGGTGGGCAAGGGCTGGATGTGAGCCCTGGCTCCCGGGTGCT CCTGGGGGCTGCCCAGGGCCCTGAGTGGGATCCTCCGCTGCCCAGGGACATCAAGGATCT GGCCGCCCTCAGGGTGCAACTGCGGGAGCAGCACCTCTACTACCAGGACCAGCTGCTGCC GGTCAGCAGGATCATCGTGCACCCACAGTTCTACATCATCCAGACCGGGGCGGACATCGC CCTGCTGGAGCTGGAGGAGCCCGTGAACATCTCCAGCCACATCCACACGGTCACGCTGCC CCCTGCCTCGGAGACCTTCCCCCCGGGGATGCCGTGCTGGGTCACTGGCTGGGGCGACGT GGACAATAATGGTGGGTGTTGGGGACAGCGGGAGGCCGGGCCAGGTGGGCACCAAGTCAC AGCCACAGGCCAGTCCGTGGGGTGACAGGGTCCCTCAGGGCGGCTCAGGGAGGGGGACTG TGGAGGCCAGGATGGATGGAGCAGGCGGTGGCGAGAGGCAGCAGGTGCCCTGAGCAGAGA CGGTGAGTCCAAAGGGCCTGGGCGTCCCCCACCCCAGGGGTTTGGAGAGTCCCTTAGCAC CTCCGTGCCTCGGTTTCCCCTTGCCTGAAAGGGTGCATCAAAAGTTTGTACGTCACGGAC TTGCTATGTGGAGAGAGAAATCACACGGGGGTCTTGCTGGAAGGAGAGAGACCGGTGCTG GGATGAGACCTGCCTGCCCTCCATCCCTGTGCTACAGACAAGGCAGGGGCCTGGGAATCG GGGTCGTGGCAGTGCTGTGGGGGGCTGGACGAAGCTCACTGTGGCCCTCCACGAGGCACA TTTTCACTTCTAGAAGGTCTTGTCCCCATTTTATCCACAATTCAGAGCAAAGCTTTGGGG TACAGCCTGAGCGGCAACCCTGGGCTGTGACCTCTGGGTCACTCAGAAGGGGCCTGAGCC ACTGTCCCGCTATTCCGCCCCACACAGCGGGGAAGCTGAGCCCAGCGCCCTGTGTTCCCC TCGGCTAGGGCCAACCGTGGACCATGGGCCTAGCCCAGACGAAAGTCAGCTGAGCCCAGG GGGAGACACGGGTCGGGCTCTGCACCCCCGTGCCATGGAGCCCAGCTTGGCAACCTCCAG GGCCCTCCCCTCCCTTCCCCAGATGGGGCTTAAATGAGGCCAGGGACCCAGGACCAGCCT CAGCGGAGGGGCCTGGACTGCATTCACCGCCCCTTCCCCGGGGCTGCAGGCACAGAACAG CACTGGGCCCATGGTGCCATCTCCCCTGCCCGTGACTCTGCCACCAAGTCCACGAAGCAG CACCCAGCCGGCCCCAGACCCGGCTCCACGCCCCCCTCCGCCCCCAGTGCACCTGCCGCC GCCATACCCGCTGAAGGAGGTGGAAGTCCCCGTAGTGGAAAACCACCTTTGCAACGCGGA ATATCACACCGGCCTCCATACGGGCCACAGCTTTCAAATCGTCCGCGATGACATGCTGTG TGCGGGGAGCGAAAATCACGACTCCTGCCAGGTGGGCCCTCGCGTCCCCCACCCCAATCC CCGGAGCCTGGCCAGCGAGCGCATCCCTCATCCTGACCCCCGAAGCCTGGCCAGCGAGCA CTGACCTCTGACCTTCCCAGGGTGACTCTGGAGGGCCCCTGGTCTGCAAGGTGAATGGCA CCTAACTGCAGGCGGGCGTGGTCAGCTGGGAGGAGAGCTGTGCCCAGCCCAACCGGCCTG GCATCTACACCCGTGTCACCTACTACTTGGACTGGATCCACCACTATGTCCCCAAGAAGC CC OMIM ID 609272