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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CLCF1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 23529 Official gene symbol CLCF1 Full name cardiotrophin-like cytokine factor 1 Aliases ,BSF-3,BSF3,CISS2,CLC,NNT-1,NNT1,NR6, Gene summary This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Location Chromosome: 11   Locus: 11q13.3 Gene position 67141648 - 67131639  Map Viewer Gene orientation minus Gene size 10010 bp Gene sequence >CLCF1:complement(12437434..12447443):Length=10010 ACTTGCTCCCAGGCCAGCTCGCTGGCATTTGGGAGAATGTGTCATTGCATTTACTCAAGG GGGAGGAGGAGGGAAGGTTAGAGATGAGGAGGCAGAGGTAGGGTGGGAGCAGGGACCTCG CACAGGCAGAGGTAGGTTGGATCAGGGACCCCGCATCGGCAGGGGACAGGGGGCAGGGGG CGGTGTCCCAGGCCAACGCCTGGGGAGAAGCCCACCCGAAGCCGGCGCTGTCCCCCGGCT CCTGGGAGTCCTCAGACGGACTGATGGCCTCCCCGCCCCCTCCCCCAGGAGGCCCAGGGT GGTACCGCCACAGCCTCGCCTCACCTCACCCCCCCTCGGTGCTGTGGGAGGGAGAGGGAG CCCCAGAAGCCCTCCCTTCCCTCCTCCCCCCTCCTACCCCCACCCCGGGGAGGGCCGCTA CAATTTGTGGTTACAGCTTTACACGTCAGAAAAAAAAAAAAAAAGTTTGCAGAATGTCCC ACACCGAAAAAAAAAAAAAATCCGAAACCGAGCGAAAAAAACCTGCGAGTGGGCCTGGCG GATGGGATTATTAAAGCTTCGCCGGAGCCGCGGCTCGCCCTCCCACTCCGCCAGCCTCCG GGAGAGGAGCCGCACCCGGCCGGCCCGGCCCCAGCCCCATGGACCTCCGAGCAGGTAGGA GCCAGGCGGCCGAGGCCCCGACCCCCGCCCCGCCAAGCAGCCACGAGATCCGGTTCCCGT CCTGCCCTGACCCCCGGGAGCCCCGCGCCGGGGCCGGGCCAGGGAGCTGGGCTCGGGCCG GGGGAGGCACGGCTGGGCGCCCTCGAGAGGGGCCGGGCGGGGACGCGGCATTCCTGGAGT CCGCACGGCGGGGCCAGGAGGTGGCCGGGAGCGGCGGGGAGCCCGGACGATCGCAGACCT GGGGAGGCGGCAACCTGGAGCCCCAGCGAGGCGGGCCGTAGGAGCCGCAGCCCCAGAGCC CCGCGCACCAGTCGGGGCCAGAGAGTCCGAGGCGGGGAGCGAGGCTGCGGGTGGGAGGAG GGGCTGGGAGAGGAAGAGGGAGGGAGGCCGGGGGAGCCCGAGGCCGGGCGGCGGGAGGCG AGGGGAGGCCGACACCTCGGGCCGCGCCGCTCTCCCTCCCCGGCCCGCCGGGAGGGGTAG GAGGGCGGGCGGGAGGAAGGGCGGGCGGCGGAGAGGAGGGCGGAGGGCAGCGCCGAGCCT GGCTGGGCCGGGCCGGACGGGCCGAGCCGCGCCGCGGGACTCGCGGCTTCCTAGCTACGC GCCGCGCGGCCGGAACCCTCCATGGTGCCCACGGCCGGGGAGCCGGCGGCAGGTAGGGGC GGCGGGCGGCGGCCGCGAGTCCCCCGGGCCACCGTGGCCTGGGAGTGATTATTGTTTGGC GGGGGGCTGGCGCAGCCGGGCCGGACCCGGCAGGAAAAAGTCTGTCACTGGCCAGGGAGC GGCGGGAGCAGCCGCTCAGCCCGGGCAGGAGGGGAGTTGACGCGCGGGAAAGGGCAGCGC CGGGCAGAGCCCGGAGCCCGGTGCCCCGGACCCCGCCCCCGCCCCCGCCCCCGCCCCCGC CGCGGGGAAGGAGCGACCGGGCGGGAGCGGGAGGGGGCGGGGCCGGGGGCGCCGAGGCCA CACAGGGGGAAGGCGCAGCGCCGGGAGGGGTCCCAGAGCGAGAGGTCACCGCCAGCAGGG AGGGCCAGCTGGCAACCGCCGCCGTGCAGCTTCCCGGCCGAGCCCCTCGAAGGAAACCTT CGAAAGAGTCCCCGGGGCTCGCCAGAGGTCCCCTCATGCTTGCTCTCCCCACCCGCCTTC CTTTCCACAACTCCGTGCTGGGCTTCTGGAGCCCTCCCCACAGACCCTCCCAATCCCAGA GGACCCCTGTTCCCCCAGCTCCCAGCCTGGCCCTCCCCCCGGGGTGTGAGGGGCTACCAG GAGAGGAGGGGAGACGGGCGGGTGGAGGCTAAGCCTTGGAGAGAGGCTAGGGGTGGGGGG CACTGGGCACGCTGCTCTACTGGGTCCTCCTTCTCTGACCCTAACCCAGGGACACCTCTG TGCTTTCACTGACCCCGACTGACCTCCGCCACAGCTCGGGAGCACACGTTGCCCCTCACA CCGGACAGGATGCGAGTACATATTCCCCTAACAGACCAGACGCGCTCCTGGCCAGCTCAG ACACCCTCGCTGCCCTGGAGCCACACGCTCCACCGGGGAGGAAGCAGAGATGGCAATTGT CACCCGGCAGCCCCAGAAGTGACACTGCTGATGGGTGCAATGGCTCCCTGTCCCCTTCAT TCACAGACCCACACTCTTGTCCGTCACACTTCTGCACACCACCCCTGCACGCCACCCCTG CACACCAGCCACTGGCTCACTGACACTTCACATTCCTCCCCACGTCCCACCTCTTGTGCA CACCTGGCTCCTGCACTCTCCTCCCCCCCCACGCCCCTCTTGATAACAACACCCTTTCCA ATTCACCCACCACTGCCCTGGACTCCTCCTTCACTGCTCCTCCTGCCTCTGGCTCTCAGT GGGCTGCTGGGCTCCCCCCTGGCTCCCCGCTGGCCTCCCTGAGCACACCCATGGCCCTCT TGTGGCACAATCAGGAACCCTCTCACTCCAGCCAAAGCCCAACTCCTGTCTCGCTTGCTT GGTTACTGACTTCATAAGGCAGTGGGGCTGGCCCACCCTCAGCTTCTTCCCCTGGGCCTC AGTGACCTCTGTCATTTAGGCTGGAGGAGAAGGGCACAAAGGGGGATGCTGGAGAGGAGA GGAGAGATGAAGCCCCGTGTGTTTCCTCTAGGAGGAATTGAGCTTGCATAATGTGACCTC CTTGTGCAAGCCCACAGTCACCAGACGAATTGGTGGCAAAGCTAGGTCTCCCAATTCCCA GGCCCATGTGTCCCCACTCACCAAGCTACTTCTCAGTGGCCTGGGGTAAAAGGAACCAAG GAAAAGGCAGAAGGGAGATAAGTAAGAGAGGGGAAAGCAGCAGCCCAGAGGGTGGAAGGA AGATGGGTTTCTGTGGGCCTTTGCCTGGGAAGGTAGGTCAGGACACGCCCCTGGGGCAGT TTCCTACCGTCACAATGCCTGGACCTCACCCACTCCATCCCTAGCCCACTCCTCACCCAC TCTGCCCGCCTAACCCACTCCATCCCTCAATTCCCCTCAACAGACCCCTCCAACCGCAGC CAGCGCTGGTCCTGGTCTGGCCTTTCCTCCTGGCTCCCATATTCAGCCCAGCCTGAGGCC ACCATGCCCCACCTCTGGAGCTCTGCAGTGCCTCCCTGGCTGCAACATTTAGGGCTTACA GTTCTTAGCGTAGCTCTTATAGTCCCAGGTGCAGAGACTCCCATTGACTTGTCCTACCAC CCTAAGCACCCTGGCACATCTGCATGGCTGAACTCTCACCCTCACTGGGAAAGGTCAGCC TGGGGGTGTCCAGGCCAGGGACTGAGGGGCAGCTGGCTAAAGTGGCTAAAGACATGTGCT CACGGGTGCGCCTGCCTGTGCAGCTGTCTGGGTGGCCAGTCACTTCCTTGGGCTAAGAGA GAGAGAGTGTGTGTGTGTGTGTGTGTTCATGAGGAGAGCCTTGGTTCCTAGGGCCCAGGG ATCTGGATGGAATTAGGGGCTGGCCGGGGGTGGGGGGCTGTTGCAGGAAACGTGAGCTGT ACTCGTTAGCTCCTCACGTGCTCAGCCGGATTTATAAACACACAGAGAAGACGGGATGTA AACAATCAGTGGGCAGCAGCCAGAGGCAGAGCTGGGGCGGGGGCCGGGCTGGGGGCCAGG ACTGGTGGGGAGGGGGAGAGGGGGACCTAGGACACAGCCCCAGTGGCCGGGGTCCACCTG CACAACATGAGCCTGAGGGAGGATGGATGAGGGCTCCAGGAAGCCCACCACGCACTCTCC TCAGGAGGCAGGCGAGCTGTGTTGGGTTCCCAAGCTCACGACTAAACCGCAGGTGTTCAC CCCACGCTGCTTTCCCTCCTGCTGCCTGAGACACGGGCATGGCTTTGCCCAGAGTGGAAG CTGTCATAGCAGGGGCAGAGCCCTGTCCTTCTACCCCCCCTTTCTTTTCTCCTAACCTCT TCTCCCTCTGGATTCCTGAGAACCCTTCCCTCTTTCTGGTTCTGTGGGCCGTCGGATCCT TCTGTTCTCCCCTGCCCCCCACCCGCAGCCTGCAACGACACAGTTACCTCAGAACTGAAA TATTCCTGGAAACACCGGCCTCGTCTGGTTAATTTCATGAGCCGTTTTTTTCTGCCCAGA TGACTTAGTTCTTGTCTATCCAAAGGCTTCTCCCCCTGCTGTCCCTGTGTAGGGAGCTGA TCTCCCCTAGGGATGTCCCACAGGGCTCAGAATGGGAGAGGGTAAGTTCTGAGCTGGGTT CCTGACTGTACCTCTTGGCCATGACAAAGGCAGAGCCTAGAACTCCGGCCAGCATGTGGG TAAAGAAGGAAGCCTAGCTCCCAGCTCCGGCTTCAGTTGGGACCCTTGGTCTCGCCACTA ACTTTGAGTGAAGCCAGACTCGATGCTGAAAGCGACCTCAAGGCTGGGAGGGCCGCTGCC CAATTCAGCAGGTCTCCAATCTCCAAAACTAATGCTACTCTGTACCCATAGGATCCTAGA GGTGACTGCCAGATCCCTAGGCTTGGAGTTGTGTTGAGATGTGAGGAGCAGGGAGGAGAA AGGAACTGAGTCAGGCAAGAGCTGGGGATAGAAAGGAAGAGTGAGGAAAGCAGCGTCCAG GAGGAAGCCACAAGCTCAGAGGGGACAGGAAAGGGTGAGCTGGTCTCCCCAGGGAGCAGT TGAGTGCCTGACCCTACTCTCTGTCCTAAAACACACGCGTGTACACACACTCACACTTGC CTCAAACCAAGACCCTGTGACTTGTGGTACCCCACCGCCACGCTCCCTTAGTAAAGCCGG CCAGTCACACATCTGAAAGAGTCCAGACTGACCAGGTGGGCCACTGCCGAAGTCCTCACT GACCCCTGTCCTCCATAAGAGATGTTTTATACAAATGGAGTCTTGCATCCTTCCTAGTTA TTAGCCCTCTCCAAAACTGCCCCAGCACTGTGATTAGACCTAACCTAGTCTTCATTCTTT CTTGAATCCAAATCCCATCCTAACCATGGGCAAAGCGTTATACCTATCTAAGTTATTTCT GCCTATCAAAGCAACCTATGTCATTATAGAAAAATCTGAGAGTATAAAATATGAACTATA GGGGTGGTGGAAAGAGAAGGTGGCAGCAAAAAAAAAAAAAAAAAAGGAAAAAAAAAGAAC TATAGGAAAGAAACCACTCATGACCTCACACCTATTCAAGCTGAAAACCCAAACTAGCCC TGCTCTTCATAACATGACAAGCAGCGCCCCATCTGATACCTAAACCGACCAAGTCACAGC CCTCCAACTCACCCTCTGCCTGCCCAGACCTCACCACATCCTTGCTGGACTCAAACCTCA ACCGCACTAAATCAACCAAATCCCAAGTCTAAACTAATCTGAAACTTTTAAAGTAACCCA GTCCTTAAACCTAACCTAGCCCAATGCCAATTATATCTACCCTAGCCAAACCCTAACTGC CTTTGCCAGTCCAAAGTGTCCACTGAATCCTCACCTTGGTCCTCACTTAAAATCCCAGAA AAGCATATTTCCCCACTGCCCACATCCCTCCTTACAGCACCCAACCCTGGCCTCTGGACT CCTGGTATCCTGGGATGTCCAAACTCTGCAGTGCCATCAGCCAACAAGCCCGACTCGTCA AATGCACCTCTCTCCCTTCCTGTCCCCACCCTTGCAGGCTGATGGAAAGGCCTCATTGAA GTCCAACTTTTCCCCACCTAACACCAAGAACGGGGTGAACCTCCACACTGCCACCGTTCC CTGAGAGTGAGCACTAAATCTCCTTCAATCTAACCCCACCCTACACTTCCCACACTCAGG AATCACATCCTAGAATATACCCAAAACTAAGCCCCATAAGGCAGCCCGACCCTAGTGGTC TAACCCTATACCTTGCTTCCTATGGGTGAGTCTGTTCTTGGCGGCCGCCTCTCTCCTGCT TCCTCCCTTAGGGCTGACTGTGCTCAGCCTGCCAGCTCTGACATGTGCTGTCTCCCACCC TCTGACTCCCCTCAAGCTGCAGTGGGACTGAAGACTGGCAGGAAGCTAGGGTACAACTGG AACACAGGCAGGTCGACCTGCAGTCCCTAGGCCTGGCCCCGTCCCTCCATGTACACACAT ATACATGTTGGCACACACACAGTGGCACACATGCCAAAGACTCTCTCAGCTGACACACAG ATCCATTCTCAAGTATCTACTGATAGACACTCATGCGTGCCAAGTCCTCATCCTCAAACA TACACATGCCTCTCTTTCTCTCCCGTCTTGCCAGGAGTGTTTCCCCTCCTCCATCCCCTC TGCCTCCCATCTGGTGTCCCACCCTCACCCCCCACCCAGCCCAAGGTGGGGACAGACACC TGAGGGGCTGCCAGCTGCTTCCCCGTGTGGGCCCGGGCCGCGCTCATGCTTCTCGTCCAT CCTGCCCACAGGGGACTCGTGGGGGATGTTAGCGTGCCTGTGCACGGTGCTCTGGCACCT CCCTGCAGTGCCAGCTCTCAATCGCACAGGGGACCCAGGGCCTGGCCCCTCCATCCAGAA AACCTATGACCTCACCCGCTACCTGGAGCACCAACTCCGCAGCTTGGCTGGGACCTATGT GAGTATCCAGCGTAGGAATCTGGGAGTTGGGGAGGAGTGAGGAGTTGGGGAAAGACAGTC CTAACCGTGGAGGGTTCTGGTAAATGATGGGGTGAGGAGGGGCTCTTTGGCTCCCACCAG TCCCCCTGTCTGGTCTATCTCCTGCCCTTCCCTCTTAGGTGGCCCCCCCACTTCCCCATC CCTGGCCCCAGGACTAGGCATGTGGGCAGGCCTCGCACCCGCCTTGGCCCATTGCCCCAC TGGCTGCCAGCCCAGCCGCCCGCCTCCCCCTGGGGGCCGGGGAAGTCTCCTCTGTTTACA CCGTGTTGTGGTGTCTCTTGCGCGGGCGGGGTTGGGTGGGGACAGAGGGGCCCCACCTCC CATGCCTGCGTTCCAGCTCGCCTCTGCCCCCAGACCTGGGGCCCTGCTGCTCTGGACCCA GGGGCCTCCCTTCCGTCTGCCTCTCCCATCCTAGCTGGGCCTCCTAGGGGGGTCATGGGG GAAGGGGACTGTAGGGAACCCAGGCAGTAGTGGCAGGGGGTTTAGGGTGTGGATGGAGGT TATGCTGTAAGGATTTGGGGGTGGTCCAGAGGTGTTCAGAGAGCCCAGGAGAGAAGGAAG GAGGGTTGGAGGAGCCGAGGACCATGGGGAACCGGCCCCCTCTTCCCGTGTTCCTCTTCC ACATCCCAGACCCTACTCTGGAGCCAGGGAAAGAAAAGGGAGGAGGGTGGCGGGGGAGCT GGCTCCAGCCCCAGGATACACCGAGGAAATTAGTTTGTCTCTGTGCTTGTCAGCGTGTGA ACCTCCCCCTGGGCCCTTGCCTATCCCAGGCCTCTCCCCTTGCTTCTCCCTTCTTTCCCA GTTATACATCTCCCTCATCCCTTTCCCTGGGCCCCAGCCGCTCCCCCGAGGGTTGGAAAG GGCTCTGCCCTCTTCCCTATACCATGCTGTCTTCCATAGCCTTCCTCCTGTCCTACTCAT GAGACTGCCTCCATTTCTTCCTTCTGCAACCCTGCTCCTATCAGCTGAACCCTTCTTTCG GAGTGTTAGTGAGTACCCGTCTCTCCCCAGCCCCTCAGCTGGTGGGCCTGGGTGTGTCAG CGGCAAATGGGGCTCTGGTTCCAATGGGCCACTCTCATCTCTCTCTTGTTCCTTGTGCAG AAAACCTTTGCTTCACTCCACTGCCCTCTCTAGTTCCCGACCCTTTTTCTCTCCTGGCTT TCCCTGCCAAATTTCTCCAAGGAGTGGTCTACACCCTCTGCCTCCACTTCCTCTCCACCC ACTCACTTCTTAACCCCCTGCAATCTGGCTTCCAGGCCCCAGCAATGGTTCTCTCCAAGG TCGTCAGGCACCTCCTTGCCAAGCCCGACAGTGTTTTGAAGGCTCATTCTCCTTGCTGTC TGTTTTGCAGCCACACTGCTGAGCGCTGCTGCCTTCTCGAACTCCTCTTCCTTGGTCTCT GCACTCTCCTGGGCCACCTTCTACCTCTCCAGCTCCTCCAGGCTCCTCTTCCTCTCTGTC CTGCCCCCACAGCGGGCACTCTCCCAAGGTTTGCCCACCCAGCCAATCAGCACGTCCTTC CTGAGCGTCTTGTGCGTCTCCTCCTCCTCCTTTTTCTACGCCTCTCCATTGGAGAGCTCA CCACCGCCACTGCTTCAACTGTCACCTGCATACAAATGATATCCTTATTGGAAAAACTCA GGGAGGCCATGAACAAAGAAGCCTAGCATGGAGACAGGGCCAGTGTCAGGGGACACAAAA AATAGAAACTTTGGGAGCAGGTATCTCCTTGGTGGTGAGCCAGCGGCTCTGCCCTCCTCC TTCCCCATCACCCTCTCCTTTTCACAGCTGAACTACCTGGGCCCCCCTTTCAACGAGCCA GACTTCAACCCTCCCCGCCTGGGGGCAGAGACTCTGCCCAGGGCCACTGTTGACTTGGAG GTGTGGCGAAGCCTCAATGACAAACTGCGGCTGACCCAGAACTACGAGGCCTACAGCCAC CTTCTGTGTTACTTGCGTGGCCTCAACCGTCAGGCTGCCACTGCTGAGCTGCGCCGCAGC CTGGCCCACTTCTGCACCAGCCTCCAGGGCCTGCTGGGCAGCATTGCGGGCGTCATGGCA GCTCTGGGCTACCCACTGCCCCAGCCGCTGCCTGGGACTGAACCCACTTGGACTCCTGGC CCTGCCCACAGTGACTTCCTCCAGAAGATGGACGACTTCTGGCTGCTGAAGGAGCTGCAG ACCTGGCTGTGGCGCTCGGCCAAGGACTTCAACCGGCTCAAGAAGAAGATGCAGCCTCCA GCAGCTGCAGTCACCCTGCACCTGGGGGCTCATGGCTTCTGACTTCTGACCTTCTCCTCT TCGCTCCCCCTTCAAACCCTGCTCCCACTTTGTGAGAGCCAGCCCTGTATGCCAACACCT GTTGAGCCAGGAGACAGAAGCTGTGAGCCTCTGGCCCTTTCCTGGACCGGCTGGGCGTGT GATGCGATCAGCCCTGTCTCCTCCCCACCTCCCAAAGGTCTACCGAGCTGGGGAGGAGGT ACAGTAGGCCCTGTCCTGTCCTGTTTCTACAGGAAGTCATGCTCGAGGGAGTGTGAAGTG GTTCAGGTTGGTGCAGAGGCGCTCATGGCCTCCTGCTTCTTGCCTACCACTTGGCCAGTG CCCACCCAGCCCCTCAGGTGGCACATCTGGAGGGCAGGGGTTGAGGGGCCACCACCACAC ATGCCTTTCTGGGGTGAAGCCCTTTGGCTGCCCCACTCTCCTTGGATGGGTGTTGCTCCC TTATCCCCAAATCACTCTATACATCCAATTCAGGAAACAAACATGGTGGCAATTCTACAC AAAAAGAGATGAGATTAACAGTGCAGGGTTGGGGTCTGCATTGGAGGTGCCCTATAAACC AGAAGAGAAAATACTGAAAGCACAGGGGCAGGGACAGACCAGACCAGACCCAGGAGTCTC CAAAGCACAGAGTGGCAAACAAAACCCGAGCTGAGCATCAGGACCTTGCCTCGAATTGTC TTCCAGTATTACGGTGCCTCTTCTCTGCCCCCTTTCCCAGGGTATCTGTGGGTTGCCAGG CTGGGGAGGGCAACCATAGCCACACCACAGGATTTCCTGAAAGTTTACAATGCAGTAGCA TTTTGGGGTGTAGGGTGGCAGCTCCCCAAGGCCCTGCCCCCCAGCCCCACCCACTCATGA CTCTAAGTGTGTTGTATTAATATTTATTTATTTGGAGATGTTATTTATTAGATGATATTT ATTGCAGAATTTCTATTCTTGTATTAACAAATAAAATGCTTGCCCCAGAA OMIM ID 607672