Entrez gene ID | | 23532 |
Official gene symbol | | PRAME |
Full name | | preferentially expressed antigen in melanoma |
Aliases | | ,CT130,MAPE,OIP4, |
Gene summary | | This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq] |
Location | | Chromosome: 22 Locus: 22q11.22 |
Gene position | | 22901696 - 22890123 Map Viewer |
Gene orientation | | minus |
Gene size | | 11574 bp |
Gene sequence |
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OMIM ID | | 606021 |
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