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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CASP14 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 23581 Official gene symbol CASP14 Full name caspase 14, apoptosis-related cysteine peptidase Aliases ,MGC119078,MGC119079, Gene summary This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq] Location Chromosome: 19   Locus: 19p13.1 Gene position 15163015 - 15166900  Map Viewer Gene orientation plus Gene size 3886 bp Gene sequence >CASP14:6425817..6429702:Length=3886 AGGATCAGACAAGGGTGCTGAGAGCCGGGACTCACAACCAAAGGAGAAATGAGCAATCCG CGGTCTTTGGAAGAGGTAGGCTGGGTGCAGGTTGAGGGGAGGGTGATCATCTGGGGAGAA GGAAGGTGAGGATTTTAATGTTTTGGAAAGAGTGGAGGGACTGAAAAAATCATGATCTGA ACTCAGAGCTAGGAGGTACTTTGTAGTCAATCAAACAGCAAAAAAAGACTCAGAGATGGA ACCGAAGTTGGGTTGGGTGGTGGGGGCAGTCAAACACAGCTACCTCTGTCTCCAAAGATC AAGTTCTTCTCAACACATTAAAGGTTCTGAGAAGTCCTGCAATAAACAATTTCATGTTGA TTTTTTAAAAGATGAAGTTCTTACCACTGGGGTGCTCAGTACGCTGCTTCTGTTCTGGAA AGAACTGTTGACCCCCAATATTCTTCTTCCTCAGACGGGATCTCAGTATTAGCTTCAGAA ACTCTGAGACCTCTGCAAGTGAGGAGGTAATAGAGGAATGCTCAGAACACTCTTGGGGAG GATGAGGAGACCTGCAAATCCACAAAATACGACAACTGGAAGGGATCTTCAAAATCACAC ACACACTCATTGTCTATATTTGGAAACTGAGGCTCAGATGGGAGCAGTGACTTCCCCCAA GTTCATACCAAGCTAGAAAAGAGCTGGACCCCAGGTTGGGTTGCTGTATTTGGGAACTAA AAATAAAGGACACCCAATTCAATTTGAATTTCACATCAACAACAAATAATTATGTAGTAT AAGTATATCCCATGCAATATTTGGGATATACTTATACTAAAAAGGTATTTGGTTTTTATT TGAAATTTAAGTGTACCTGAGCATCTTCTATTATACCTGGCAACCCTAAGCCCAAGCCTC TCTTGTTTTGTTTGTTCATTTTTGAGACAGGGTCTCACTTATTGCCCAGGCTGGAGTGCA GTGACAAGATCATAGTTCACTGCAGCCTCAACTTCCCAGGCTCAAGCTATCCTCCCACTT CAGCCTCCAAAGTAGCTGGGACCACAGATGCACAGCAGCACACCCAGCTATATTTTTCAT TTTTTGTAGAGACAGAGTCTCACTATGTTGCCCAGGCTGGTCTCGAACTCTTGGGCTCAA GCAATCCTCCCACCTCGGCCTCCCAAAGTGCTGGGATCACAGGCATGAGCCACCACACCC AGCCTGCATGCCTCTTTTGACTACATCTGCTTCTCCTTGAACCTCTCCATGCTGATTTCT GTCTTCTCTTGGCCCCAGGAGAAATATGATATGTCAGGTGCCCGCCTGGCCCTAATACTG TGTGTCACCAAAGCCCGGGAAGGTTCCGAAGAAGACCTGGATGCTCTGGAACACATGTTT CGGCAGCTGAGATTCGAAAGCACCATGAAAAGAGACCCCACTGCCGAGGTATTGGGGTGC CTACTCCAGGCCTGTTTGGGGGAAAGGTACTAGGTTGGAAGTGTAGGCTATGGGGACCCA GCTGAGTCTGGTTCTTCCTCTCACTCCAGCAATTCCAGGAAGAGCTGGAAAAATTCCAGC AGGCCATCGATTCCCGGGAAGATCCCGTCAGTTGTGCCTTCGTGGTACTCATGGCTCACG GGAGGGAAGGCTTCCTCAAGGGAGAAGATGGGGAGATGGTCAAGCTGGAGAATCTCTTCG AGGCCCTGAACAACAAGAACTGCCAGGCCCTGCGAGCTAAGCCCAAGGTGTACATCATAC AGGCCTGTCGAGGAGGTGGGGACAGATCCAAGAGCACAGAGTCTGTGGTTTGTTGTTTCT GTTTTGTTTTTTGAGACAGCACCCAGGCTGGAATGCAGTGGCGGAATCTCAACTCACTGC AATCTCCATCTCCCAGGCTCCAGCCGTCCTCCTGCCTCAGCCTCCTGAGTAGCTGAGACT ACAGGCTCCCGCCACTATGTCAGGCTAATTTTTGTAGACAGGGTCTGATTATGTTGCCCA GGCTGGTCTCAAACTCCTGAGCTCAAGCAATCCTCCTGCCTCAGCCTCCCACCATGCCCA ACCAAGTCTGTGTTTTTATCCAAGCCAGTCCCAGATCCAAAGCCCCAGCTGAAGCCAGGC ACCATGGCTCATGCCTGTAATTCCAGTACTTTGGGAGGCCCAGGCGGGAAGATTTTTTGA GGCCAGGAGTTCAAGACTAGCGTCGAGCAATGTAACAAGAACCCAGCTCTATGAAAAATA TTAAAGATTAGCCAAGGGCATGGTGGCATGGGCCTGTGGTCCTAGCTACTCAGGAGGCTG AAGTAGGAGGATCACTTGAGCCCAGGAGTTAAGAGGCTGCAGTGAGCTATGATTACACCA TTGCACTCCAGCCTGGGCAACAAAGCAAGCCCCTGTCTCTAAAAAGTTAAATTAAATTAA AAAGCCCCACTGCACATGGCATACCACAAAAGCATCCTTTTTTTTTTTTTTTTTTTAGAC GGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCGATGGCACAATCTTGGCTCACTGCAACC CCCACCTCCCAGGTTCAAGCAATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAG GTGCAAGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGATTTGACCATG TTGGTCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCTGCCTTCCTCAGCCTCCCAAA GTGCTGGGATTACAGGTGTGAGCCACCGTGCCCAGCCCTTACCTTTCTTTTTAAGAGGCG ACATCTCGCTCTGTCTCCCAGGCTAGAGTGTAGTGGTGCAATCATGGCTCACTGCAGCCT CAAGCTCCCAGGTTCAAGTGATCCTCCTGCTTCAGCCCCCCAAAACACTGGGAATACAGG TGTGAGCCACCCTGCCCAGCCCCTTTCCTTACCTTTCTCTCTGACTTTGCCTCCTCCTCT TCTTGTTGTTTCAGAACAAAGGGACCCCGGTGAAACAGTAGGTGGAGATGAGATTGTGAT GGTCATCAAAGACAGCCCACAAACCATCCCAACATACACAGATGCCTTGCACGTTTATTC CACGGTAGAGGGTATGAGCTCCCAGCTGGCCCAGGGATCCCTCTGCTCTTCCCCCTCTCC TGCCACTCCCAACTCCTGAACCTCTCCTCCAGGACCCACGCCCTTCCAGGATCCCCTCTA CCTACCCTCTGAAGCTCCCCCGAACCCACCTCTCTGGAATTCCCAGGATACATCGCCTAC CGACATGATCAGAAAGGCTCATGCTTTATCCAGACCCTGGTGGATGTGTTCACGAAGAGG AAAGGACATATCTTGGAACTTCTGACAGAGGTGAGTTGACAAAAGGTAGCTGGGACCACC GCCCAGGCCAAGAAGGGTGCAGGCGGAGGGGGCTGAGCCTCCTCCTAACCCCTCTCCATT TCCCTCAGCTCCAAATCCAAGCCAGATCTCAATACAGAAACTAAGAAGCCCACTTTCCAA CAACTTTCCCAAATGCAGGGACTCTTAAAAGCCACAGTATGGGAGATAAATTTCTATAAA CAAATCCCCCTTGGATATAAACAATGTTTGGGCAAACTGTTTTCTTTTAATGTTTATATG TTTTTATTGCAAATTATTTAAAAAATGCCCAGCCAAGGATTCCATACAAACTATGGTATA GGAAGAGGCCACAACGGTCTCTCATCTTAGGACAAGAATACCCACCTGCCCCGTTCCCTA ACCCTCCCCCCATAAGTCCATGACACTGACTCCTCCAAGCTCACCACACCTGTTGCTGCA GGTGACCCGGCGGATGGCAGAAGCAGAGCTGGTTCAAGAAGGAAAAGCAAGGAAAACGAA CCCTGAAATCCAAAGCACCCTCCGGAAACGGCTGTATCTGCAGTAG OMIM ID 605848