Entrez gene ID | | 23764 |
Official gene symbol | | MAFF |
Full name | | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) |
Aliases | | ,U-MAF,hMafF, |
Gene summary | | The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 22 Locus: 22q13.1 |
Gene position | | 38597939 - 38612518 Map Viewer |
Gene orientation | | plus |
Gene size | | 14580 bp |
Gene sequence |
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OMIM ID | | 604877 |
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